AHCTF1

Gene Information

Official Symbol: AHCTF1
Official Name: AT-hook containing transcription factor 1
Aliases and Previous Symbols: N/A
Entrez ID: 25909
UniProt: Q8WYP5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hinokiflavone 12μM R08 exp487	-2.27
R-DABN 8μM R03 exp111	-2.22
RK-33 8μM R08 exp518	-2.09
Thimerosal 0.85μM R08 exp529	-2.04
PU-H71 1μM R08 exp515	-2
Atovaquone 15μM R08 exp451	-1.95
Dynasore 7μM R08 exp436	-1.82
Bleomycin 5μM R08 exp459	-1.75
JQ1 0.8μM R08 exp435	-1.73
ML-792 0.2μM R08 exp505	-1.7
PFI-2 4μM R05 exp239	1.7
LB-100 2μM R05 exp210	1.75
2-Methoxyestradiol 0.55μM R07 exp310	1.8
Chloramphenicol 2μM R00 exp12	1.84
MS094 2μM R03 exp136	1.85
SGC2043 10μM R03 exp152	1.86
2-Methoxyestradiol 0.2μM R01 exp40	1.88
Nifuroxazide 1μM R01 exp51	1.92
Vinorelbine 0.001μM R05 exp249	2.06
Parthenolide 2.5μM R05 exp238	2.21
Taxol 0.002μM R01 exp54	2.21
Rifampicin 1μM R00 exp31	2.22
Prochlorperazine 5.2μM R02 exp77	2.32
BI-6727 0.001μM R01 exp42	2.37

Gene	Correlation
CDC73	0.54
VASN	0.52
PSMA6	0.518
NDC1	0.506
DTL	0.505
SNRPA1	0.484
SSH2	0.479
S1PR4	0.471
PSMB4	0.468
PSMB1	0.466
PSMD3	0.465
PSMD1	0.464
RPS28	0.463
ZFAND5	0.461
NUP160	0.459
INTS5	0.458
KPNB1	0.458
PSMD11	0.456
AAAS	0.455
PSMB2	0.455
RPS9	0.453
NARFL	0.452
ACSF2	0.451
C14orf93	0.449
TTYH1	0.447
TCEB3CL2	0.446
AKIRIN2	0.444
PRPF3	0.442
MYO1H	0.441
TBC1D3H	0.44
PSMD2	0.44
NUPL1	0.438
MED17	0.438
NUP85	0.436
NUP54	0.434
MT1E	0.434
DDTL	0.433
KCTD17	0.433
TFIP11	0.432
RPSA	0.432
SF3B3	0.43
TWISTNB	0.429
GOLGA8H	0.429
GOLGA6L3	0.429
TBC1D3G	0.428
GOLGA8J	0.428
CHMP2A	0.427
NUP153	0.427
GLTSCR2	0.427
PLK1	0.426
RPL35	0.426
SMG7	0.425
RPS2	0.424
TCEB3C	0.424
CDCA3	0.424
PSMA7	0.424
RPS12	0.423
RRP15	0.422
SUPT6H	0.422
GOLGA8K	0.42
ELMOD3	0.42
PSMD7	0.419
SEC13	0.419
RFC1	0.419
CBWD5	0.418
POLR2F	0.417
CDC6	0.417
RBM39	0.417
RRP7A	0.417
PSMC6	0.417
PSMD14	0.417
RRN3	0.416
SLC38A7	0.415
POLA2	0.415
CWC22	0.413
RIOK2	0.411
GPRIN2	0.41
RANBP2	0.41
ZNF830	0.41
CBWD3	0.409
NUP43	0.408
TBC1D3C	0.408
TRIM52	0.407
C1QTNF9B	0.406
BCL2L1	0.406
RPS5	0.405
CCNA2	0.405
TCEB3CL	0.404
RAD51	0.402
PWP2	0.402
C2orf27B	0.401
AQR	0.401
CDC45	0.401
POLE	0.401
HIST1H2BE	0.401
IGFN1	0.4
TIMELESS	0.4
ATP13A1	0.4

Global Fraction of Cell Lines Where Essential: 451/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	18/28
blood	22/28
bone	15/26
breast	20/33
central nervous system	30/56
cervix	2/4
colorectal	12/17
esophagus	3/13
fibroblast	1/1
gastric	9/16
kidney	10/21
liver	7/20
lung	53/75
lymphocyte	12/16
ovary	13/26
pancreas	17/24
peripheral nervous system	12/16
plasma cell	10/15
prostate	1/1
skin	11/24
soft tissue	6/9
thyroid	2/2
upper aerodigestive	8/22
urinary tract	12/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 994
Expression level (log2 read counts): 7.77

Expression Distribution