ARL1
Gene Information
- Official Symbol: ARL1
- Official Name: ADP ribosylation factor like GTPase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 400
- UniProt: P40616
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus. {ECO:0000269|PubMed:9624189}.
Pfam Domains GO Terms
Pfam Domains
| Arf |
| Miro |
| SRPRB |
| Ras |
| Gtr1 RagA |
| G-alpha |
GO Terms
| activation of phospholipase D activity |
| toxin metabolic process |
| protein localization to Golgi apparatus |
| enzyme activator activity |
| secondary metabolic process |
| positive regulation of phospholipase activity |
| regulation of phospholipase activity |
| positive regulation of lipase activity |
| trans-Golgi network membrane |
| retrograde transport, endosome to Golgi |
| regulation of lipase activity |
| Golgi organization |
| cytosolic transport |
| trans-Golgi network |
| endosomal transport |
| protein domain specific binding |
| GTPase activity |
| Golgi vesicle transport |
| GTP binding |
| endomembrane system organization |
| protein localization to organelle |
| positive regulation of hydrolase activity |
| Golgi apparatus |
| intracellular protein transport |
| regulation of hydrolase activity |
| positive regulation of catalytic activity |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| positive regulation of molecular function |
| establishment of localization in cell |
| nitrogen compound transport |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5446
- Expression level (log2 read counts): 5.37
Expression Distribution
ARL1 Expression in NALM6 Cells: 5.37
