MARCH5
Gene Information
- Official Symbol: MARCHF5
- Official Name: membrane associated ring-CH-type finger 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 54708
- UniProt: Q9NX47
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1. {ECO:0000269|PubMed:16874301, ECO:0000269|PubMed:17606867, ECO:0000269|PubMed:19741096, ECO:0000269|PubMed:20103533}.
Pfam Domains GO Terms
Pfam Domains
| RINGv |
GO Terms
| positive regulation of mitochondrial fission |
| regulation of mitochondrial fission |
| negative regulation of cell aging |
| GTPase binding |
| regulation of cell aging |
| protein autoubiquitination |
| protein localization to mitochondrion |
| positive regulation of mitochondrion organization |
| mitochondrial outer membrane |
| regulation of mitochondrion organization |
| ubiquitin-protein transferase activity |
| protein polyubiquitination |
| positive regulation of organelle organization |
| protein ubiquitination |
| protein localization to organelle |
| protein modification by small protein conjugation |
| zinc ion binding |
| endoplasmic reticulum membrane |
| negative regulation of developmental process |
| protein modification by small protein conjugation or removal |
| endoplasmic reticulum |
| regulation of anatomical structure morphogenesis |
| positive regulation of cellular component organization |
| mitochondrion |
| regulation of organelle organization |
| positive regulation of developmental process |
| cellular protein localization |
| cellular macromolecule localization |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| BAK1 | 0.846 |
| VDAC2 | 0.802 |
| UBQLN1 | 0.755 |
| CASP9 | 0.751 |
| APAF1 | 0.744 |
| CYCS | 0.707 |
| PLAA | 0.688 |
| HCCS | 0.67 |
| SERF2 | 0.663 |
| DIABLO | 0.646 |
| FAF2 | 0.592 |
| STAU1 | 0.585 |
| ATAD1 | 0.559 |
| MFN1 | 0.558 |
| DOHH | 0.557 |
| HSPD1 | 0.522 |
| ENY2 | 0.513 |
| FECH | 0.496 |
| HARS | 0.492 |
| GABPA | 0.485 |
| ROMO1 | 0.473 |
| METAP2 | 0.467 |
| MLST8 | 0.465 |
| RPTOR | 0.464 |
| PMAIP1 | 0.458 |
| TRIAP1 | 0.457 |
| MTOR | 0.457 |
| UAP1 | 0.45 |
| THG1L | 0.448 |
| BAP1 | 0.448 |
| DDHD2 | 0.446 |
| GFPT1 | 0.443 |
| BCL2L11 | 0.441 |
| ZZZ3 | 0.438 |
| KCTD5 | 0.436 |
| SRRD | 0.43 |
| WDR24 | 0.428 |
| ALAS1 | 0.428 |
| NSD1 | 0.427 |
| MCL1 | 0.424 |
| LAMTOR5 | 0.424 |
| RAD23B | 0.421 |
| PDPK1 | 0.421 |
| KDSR | 0.421 |
| MEAF6 | 0.421 |
| VHL | 0.42 |
| NXT1 | 0.417 |
| CSNK2B | 0.413 |
| GMPPB | 0.412 |
| NAE1 | 0.41 |
| UBA3 | 0.407 |
| WDR59 | 0.407 |
| FBXO11 | 0.407 |
| MIOS | 0.406 |
| OPA1 | 0.403 |
| ATP5J | 0.402 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 63/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 2/28 |
| blood | 12/28 |
| bone | 3/26 |
| breast | 6/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 4/20 |
| lung | 3/75 |
| lymphocyte | 3/16 |
| ovary | 1/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 9/15 |
| prostate | 1/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 2/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15886
- Expression level (log2 read counts): 5.26
Expression Distribution
MARCH5 Expression in NALM6 Cells: 5.26
