MRPS35

Gene Information

Official Symbol: MRPS35
Official Name: mitochondrial ribosomal protein S35
Aliases and Previous Symbols: N/A
Entrez ID: 60488
UniProt: P82673
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NN-Diethyl-meta-toluamide 500μM R08 exp438	-1.72
CB-5083 0.4μM R08 exp468	1.7
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.71
Dexamethasone 0.006μM R07 exp351	1.72
HMS-I1 1μM R01 exp46	1.72
CoCl2 18μM R07 exp346	1.83
Deferoxamine 11μM R07 exp350	1.86
UM0125461 0.74μM R02 exp84	1.94
Mubritinib 0.2μM R01 exp48	1.96
Resminostat 0.5μM R07 exp393	2
GSK-J4 1.5μM R08 exp441	2.01
QNZ 0.01μM R05 exp241	2.06
Thimerosal 0.85μM R08 exp529	2.14
iCRT14 30μM R08 exp492	2.27
PU-H71 1μM R08 exp515	2.32
NMS-873 0.07μM R07 exp380	2.35
Hydroxyurea 100μM R07 exp329	2.57
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	2.74

Gene	Correlation
MRPS10	0.584
MRPS21	0.573
PET112	0.566
MRPL3	0.562
MRPS6	0.562
MRPL23	0.558
EARS2	0.557
TRUB2	0.553
MRPL21	0.553
HSD17B10	0.55
NARS2	0.548
DAP3	0.547
PARS2	0.547
FTSJ2	0.544
TARS2	0.542
MTG1	0.542
COA3	0.54
MRPL18	0.535
MRPL12	0.533
YARS2	0.532
MRPS5	0.525
MTIF2	0.523
MRPS34	0.52
FASTKD5	0.519
SELRC1	0.518
MRPS12	0.516
MRPS18A	0.515
RARS2	0.514
VARS2	0.512
MTG2	0.512
AARS2	0.511
MRPL53	0.509
PET117	0.509
RPUSD4	0.508
METTL17	0.506
MRPS16	0.503
QRSL1	0.503
RNMTL1	0.502
HARS2	0.5
ICT1	0.499
COA6	0.497
RBFA	0.496
HMGXB3	0.496
MRPS25	0.495
MRPS7	0.494
MRPL42	0.493
MARS2	0.493
GATC	0.492
LARS2	0.49
MRPL35	0.486
MRPL55	0.484
MRPS27	0.482
MRPL47	0.481
GFM1	0.479
DDX28	0.478
MRPL4	0.472
LRPPRC	0.471
MRPL2	0.469
ACAD9	0.469
MRP63	0.469
KIAA0391	0.469
SCO2	0.466
MRPS26	0.464
MRPL19	0.463
NDUFA3	0.463
WBSCR16	0.462
FARS2	0.462
MRPS24	0.462
GTPBP8	0.458
TFAM	0.457
NDUFB11	0.455
MTERFD1	0.455
MALSU1	0.454
MRPL28	0.453
GTPBP10	0.451
POLG2	0.451
MRPL43	0.451
MRPL13	0.449
NDUFC2	0.448
MRPL45	0.446
MRPL17	0.444
MRPL49	0.443
COX6B1	0.442
ERAL1	0.442
COX11	0.441
MRPS2	0.439
MTPAP	0.439
AURKAIP1	0.433
COQ7	0.433
MCAT	0.432
FASTKD2	0.43
PTPMT1	0.429
NDUFA1	0.426
PTCD1	0.426
C12orf65	0.425
MRPL37	0.424
MIPEP	0.424
COX16	0.423
MTERFD2	0.422
MRPL38	0.42
NDUFA2	0.418
RPUSD3	0.416
MRPL20	0.416
MRPS22	0.415
NDUFAF5	0.414
CHCHD1	0.414
COQ4	0.413
NSUN4	0.413
SARS2	0.412
COX7B	0.411
MRPL39	0.411
GTPBP6	0.411
MRPS14	0.41
COX5B	0.41
COX4I1	0.41
MRPL52	0.409
TOMM20	0.408
MRPL46	0.408
DARS2	0.407
ECSIT	0.407
XPNPEP3	0.406
MTRF1L	0.405
MRPL1	0.401
POLRMT	0.4
CLPP	0.4

Global Fraction of Cell Lines Where Essential: 19/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	1/33
central nervous system	1/56
cervix	1/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	1/16
kidney	1/21
liver	0/20
lung	3/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 615
Expression level (log2 read counts): 5.74

Expression Distribution