Pfam Domains GO Terms
| Nup153 |
| zf-RanBP |
| Nup retrotrp bd |
| negative regulation of nucleobase-containing compound transport |
| negative regulation of RNA export from nucleus |
| multi-organism nuclear import |
| viral penetration into host nucleus |
| multi-organism cellular localization |
| multi-organism intracellular transport |
| nuclear pore central transport channel |
| nuclear pore complex assembly |
| nuclear pore nuclear basket |
| nuclear inclusion body |
| nuclear periphery |
| regulation of RNA export from nucleus |
| protein membrane anchor |
| nuclear pore organization |
| regulation of nucleobase-containing compound transport |
| negative regulation of nucleocytoplasmic transport |
| pore complex assembly |
| nuclear localization sequence binding |
| structural constituent of nuclear pore |
| tRNA-containing ribonucleoprotein complex export from nucleus |
| tRNA export from nucleus |
| tRNA transport |
| ncRNA export from nucleus |
| intracellular transport of virus |
| host cell |
| transport of virus |
| negative regulation of intracellular transport |
| protein sumoylation |
| multi-organism transport |
| multi-organism localization |
| nuclear pore |
| regulation of cellular response to heat |
| regulation of glycolytic process |
| regulation of gene silencing by miRNA |
| regulation of carbohydrate catabolic process |
| regulation of gene silencing by RNA |
| regulation of posttranscriptional gene silencing |
| viral entry into host cell |
| protein import into nucleus |
| entry into host |
| entry into host cell |
| regulation of nucleocytoplasmic transport |
| mRNA export from nucleus |
| mRNA-containing ribonucleoprotein complex export from nucleus |
| viral transcription |
| import into nucleus |
| regulation of purine nucleotide metabolic process |
| regulation of nucleotide metabolic process |
| regulation of ATP metabolic process |
| ribonucleoprotein complex export from nucleus |
| ribonucleoprotein complex localization |
| RNA export from nucleus |
| viral gene expression |
| regulation of gene silencing |
| nucleus organization |
| protein import |
| protein export from nucleus |
| mRNA transport |
| interaction with host |
| regulation of generation of precursor metabolites and energy |
| nuclear export |
| protein localization to nucleus |
| nucleic acid transport |
| RNA transport |
| establishment of RNA localization |
| viral life cycle |
| regulation of carbohydrate metabolic process |
| RNA localization |
| nuclear membrane |
| nucleobase-containing compound transport |
| protein-containing complex localization |
| nucleocytoplasmic transport |
| nuclear transport |
| peptidyl-lysine modification |
| regulation of intracellular transport |
| regulation of small molecule metabolic process |
| establishment of protein localization to organelle |
| negative regulation of transport |
| viral process |
| regulation of cellular response to stress |
| protein localization to organelle |
| protein modification by small protein conjugation |
| symbiotic process |
| interspecies interaction between organisms |
| cellular protein-containing complex assembly |
| nucleolus |
| peptidyl-amino acid modification |
| regulation of cellular localization |
| protein modification by small protein conjugation or removal |
| intracellular protein transport |
| regulation of catabolic process |
| identical protein binding |
| DNA binding |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| peptide transport |
| protein-containing complex assembly |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| establishment of protein localization |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| gene expression |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Gene | Correlation |
|---|---|
| PRIM1 | 0.564 |
| POLR2J3 | 0.516 |
| TBC1D3G | 0.51 |
| TBC1D3H | 0.508 |
| TCEB3C | 0.5 |
| SLC4A1 | 0.497 |
| DTL | 0.496 |
| CHAF1A | 0.493 |
| TCEB3CL | 0.491 |
| TBC1D3F | 0.479 |
| PSMB4 | 0.478 |
| NPIPB5 | 0.476 |
| TIMELESS | 0.472 |
| TCEB3CL2 | 0.47 |
| ZNF830 | 0.467 |
| CHD4 | 0.467 |
| TICRR | 0.466 |
| CDCA3 | 0.461 |
| TBC1D3C | 0.457 |
| SEC13 | 0.456 |
| ATP6V1B2 | 0.454 |
| AQR | 0.446 |
| CBWD3 | 0.446 |
| SLC6A17 | 0.444 |
| SSH2 | 0.441 |
| AKIRIN2 | 0.441 |
| RPS19BP1 | 0.439 |
| VASN | 0.437 |
| IK | 0.436 |
| SUPT6H | 0.436 |
| NUPL1 | 0.435 |
| ATP6V0C | 0.435 |
| SMG1 | 0.435 |
| DNTTIP2 | 0.434 |
| SUPT5H | 0.432 |
| CIAPIN1 | 0.431 |
| NUP160 | 0.43 |
| CBWD6 | 0.427 |
| C1QTNF9B | 0.427 |
| AHCTF1 | 0.427 |
| GID4 | 0.426 |
| CDH24 | 0.425 |
| DDTL | 0.424 |
| SNX15 | 0.424 |
| POLE | 0.423 |
| PSMC2 | 0.423 |
| SYT9 | 0.422 |
| COPB1 | 0.42 |
| PAN2 | 0.418 |
| CDC45 | 0.418 |
| PSMA6 | 0.418 |
| PSMB3 | 0.417 |
| PSMB2 | 0.417 |
| SRGAP2C | 0.417 |
| RANGAP1 | 0.417 |
| RANBP2 | 0.416 |
| HIST1H2BE | 0.416 |
| TYMS | 0.415 |
| SH3BP1 | 0.415 |
| ZFAND5 | 0.415 |
| RPL30 | 0.415 |
| COPE | 0.413 |
| LIPE | 0.413 |
| CLN6 | 0.413 |
| NIPBL | 0.413 |
| NUP214 | 0.412 |
| TBC1D3K | 0.412 |
| TBC1D3I | 0.412 |
| PSMD3 | 0.412 |
| ZNF655 | 0.412 |
| TBC1D3E | 0.412 |
| CBWD5 | 0.412 |
| PSMD7 | 0.411 |
| TBC1D3L | 0.411 |
| NAPA | 0.41 |
| NUP62 | 0.41 |
| NSF | 0.409 |
| RPS12 | 0.409 |
| RPL35 | 0.409 |
| MT1E | 0.408 |
| XYLT2 | 0.408 |
| SCAF1 | 0.407 |
| TBC1D3 | 0.407 |
| LOC643669 | 0.407 |
| SNRPA1 | 0.405 |
| TFIP11 | 0.405 |
| MED17 | 0.404 |
| WDR43 | 0.403 |
| KRT78 | 0.403 |
| HIVEP3 | 0.403 |
| DDT | 0.402 |
| CLASP1 | 0.402 |
| NUP85 | 0.401 |
| POLA2 | 0.401 |
| GAR1 | 0.4 |
| DDX47 | 0.4 |
| AAMP | 0.4 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 2/28 |
| blood | 0/28 |
| bone | 1/26 |
| breast | 2/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 1/13 |
| fibroblast | 0/1 |
| gastric | 2/16 |
| kidney | 0/21 |
| liver | 2/20 |
| lung | 11/75 |
| lymphocyte | 1/16 |
| ovary | 2/26 |
| pancreas | 3/24 |
| peripheral nervous system | 3/16 |
| plasma cell | 1/15 |
| prostate | 1/1 |
| skin | 3/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 2/22 |
| urinary tract | 0/29 |
| uterus | 1/5 |
Expression Distribution