PCF11

Gene Information

Official Symbol: PCF11
Official Name: PCF11 cleavage and polyadenylation factor subunit
Aliases and Previous Symbols: N/A
Entrez ID: 51585
UniProt: O94913
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene binds to CLP1 to form pre-mRNA cleavage factor IIm. The encoded protein is necessary for efficient Pol II transcription termination and may be involved in degradation of the 3' product of polyA site cleavage. [provided by RefSeq, Oct 2016].
UniProt Summary: Component of pre-mRNA cleavage complex II.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tozasertib 0.1μM R07 exp414	-1.86
Salinomycin 3.5μM R08 exp521	-1.82
Nocodazole 0.2μM R00 exp24	-1.71
Sucrose 20000μM R06 exp298	1.87
Ribavirin 10μM R01 exp52	1.91
BI-6727 0.001μM R01 exp42	2.06
Celastrol 0.12μM R05 exp225	2.11
L-BMAA 500 to 750μM on day4 R04 exp185	2.13

Gene	Correlation
TCEB3CL2	0.55
ORC1	0.528
TBC1D3H	0.523
SUPT6H	0.523
SCAF1	0.519
CBWD3	0.516
FBXW9	0.514
NPIPB5	0.512
RPS12	0.511
CBWD5	0.503
TCEB3CL	0.501
DDTL	0.498
TCEB3C	0.494
DISP2	0.49
TBC1D3C	0.488
TBC1D3G	0.487
ORC6	0.487
HMGCR	0.487
TFIP11	0.481
OGFR	0.48
RANBP2	0.479
POLA2	0.479
RPS2	0.477
NUPL1	0.475
TWISTNB	0.471
BYSL	0.47
NBPF10	0.469
PSMD11	0.467
WDR43	0.467
GGA3	0.465
CHD4	0.465
NOL12	0.464
NOP16	0.463
TBC1D3F	0.463
RFFL	0.461
RPL14	0.459
TBC1D3	0.457
C1QTNF9B	0.455
PSMA6	0.454
RAD51	0.453
MED29	0.452
TSPY8	0.451
TBC1D3L	0.45
CDC6	0.45
TBC1D3E	0.45
TBC1D3K	0.45
TBC1D3I	0.45
MED17	0.449
SSH2	0.449
PLK4	0.448
TICRR	0.447
CCDC94	0.447
LRR1	0.447
SRRM2	0.446
NOL10	0.445
DTL	0.445
PAN3	0.444
IK	0.444
KCTD17	0.443
C14orf93	0.443
COPA	0.443
NUP205	0.442
TRAIP	0.442
HIVEP3	0.441
CBWD6	0.44
RPL35	0.44
IGFN1	0.44
HINFP	0.439
RAD21	0.437
ZFAND5	0.437
PSMB4	0.436
SFPQ	0.435
MT1E	0.435
GOLGA6L1	0.434
TSR1	0.433
VASN	0.432
AQR	0.432
RIOK2	0.431
TIMELESS	0.431
SMG1	0.43
TOP1MT	0.429
TERF1	0.429
RPS9	0.428
SULT2B1	0.425
RPL6	0.425
RPS3A	0.424
HIST1H3I	0.424
PAN2	0.423
ZNF655	0.423
HNRNPA1	0.423
SUPT5H	0.421
PAF1	0.421
ANKLE1	0.419
ISCU	0.419
DIDO1	0.418
ZNF830	0.418
S1PR4	0.418
MICU2	0.417
RPL38	0.417
MYO1H	0.416
RPL34	0.416
MADCAM1	0.416
PSMC6	0.416
SLC6A17	0.414
CACTIN	0.414
ELMOD3	0.414
RPS14	0.414
PRIM1	0.414
ANKLE2	0.414
RPS19BP1	0.414
FBXO5	0.412
GPRIN2	0.409
OR10G3	0.409
HIST1H2BE	0.408
CCNA2	0.408
CDT1	0.407
GOSR2	0.407
SF3A3	0.407
ZNF541	0.407
TERF2	0.405
SLC4A1	0.404
TOPBP1	0.404
AKIRIN2	0.404
MED14	0.403
CDC45	0.402
COPB2	0.402
CEP192	0.402
EXD1	0.4
ATP6V0B	0.4

Global Fraction of Cell Lines Where Essential: 615/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	23/28
blood	25/28
bone	25/25
breast	30/33
central nervous system	47/56
cervix	2/4
colorectal	15/17
esophagus	11/13
fibroblast	1/1
gastric	10/15
kidney	18/21
liver	16/20
lung	67/75
lymphocyte	13/14
ovary	21/26
pancreas	19/24
peripheral nervous system	16/16
plasma cell	12/15
prostate	1/1
skin	21/24
soft tissue	7/7
thyroid	2/2
upper aerodigestive	16/22
urinary tract	22/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 706
Expression level (log2 read counts): 7.43

Expression Distribution