RPS5
Gene Information
- Official Symbol: RPS5
- Official Name: ribosomal protein S5
- Aliases and Previous Symbols: N/A
- Entrez ID: 6193
- UniProt: P46782
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ribosomal S7 |
GO Terms
| ribosomal small subunit assembly |
| regulation of translational fidelity |
| rRNA binding |
| cytosolic small ribosomal subunit |
| ribosome assembly |
| ribosomal small subunit biogenesis |
| SRP-dependent cotranslational protein targeting to membrane |
| cotranslational protein targeting to membrane |
| protein targeting to ER |
| establishment of protein localization to endoplasmic reticulum |
| viral transcription |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| viral gene expression |
| protein localization to endoplasmic reticulum |
| translational initiation |
| ribonucleoprotein complex |
| protein targeting to membrane |
| mRNA binding |
| structural constituent of ribosome |
| nuclear-transcribed mRNA catabolic process |
| mRNA catabolic process |
| ribonucleoprotein complex assembly |
| ribonucleoprotein complex subunit organization |
| RNA catabolic process |
| establishment of protein localization to membrane |
| ribosome biogenesis |
| protein targeting |
| nucleobase-containing compound catabolic process |
| translation |
| peptide biosynthetic process |
| focal adhesion |
| establishment of protein localization to organelle |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| ribonucleoprotein complex biogenesis |
| organic cyclic compound catabolic process |
| protein localization to membrane |
| amide biosynthetic process |
| peptide metabolic process |
| mRNA metabolic process |
| viral process |
| protein localization to organelle |
| organelle assembly |
| symbiotic process |
| cellular amide metabolic process |
| interspecies interaction between organisms |
| cellular protein-containing complex assembly |
| cellular macromolecule catabolic process |
| intracellular protein transport |
| macromolecule catabolic process |
| RNA binding |
| organonitrogen compound biosynthetic process |
| protein transport |
| intracellular transport |
| peptide transport |
| protein-containing complex assembly |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RPS3A | 0.55 |
| RBBP5 | 0.545 |
| RPS28 | 0.538 |
| RPS12 | 0.535 |
| RPS11 | 0.534 |
| CDC6 | 0.528 |
| RPS2 | 0.523 |
| TFIP11 | 0.521 |
| PSMB4 | 0.52 |
| RPL35 | 0.51 |
| C14orf93 | 0.5 |
| PSMB2 | 0.499 |
| TBC1D3G | 0.498 |
| POLR2J3 | 0.495 |
| TCEB3CL2 | 0.494 |
| CCNA2 | 0.493 |
| CBWD5 | 0.487 |
| TCEB3C | 0.486 |
| RPS16 | 0.486 |
| TBC1D3F | 0.485 |
| TBC1D3H | 0.483 |
| MYB | 0.483 |
| RRP7A | 0.482 |
| POLA1 | 0.482 |
| PSMC5 | 0.482 |
| TBC1D3K | 0.479 |
| TBC1D3I | 0.479 |
| TBC1D3L | 0.479 |
| TBC1D3E | 0.479 |
| HIVEP3 | 0.479 |
| DDX56 | 0.478 |
| CBWD3 | 0.477 |
| TBC1D3 | 0.476 |
| BYSL | 0.475 |
| ACSF2 | 0.47 |
| PSMB1 | 0.468 |
| GOLGA6L3 | 0.465 |
| CHD4 | 0.464 |
| GOLGA8O | 0.462 |
| ISCU | 0.462 |
| UTP20 | 0.461 |
| SUPT5H | 0.46 |
| RIOK2 | 0.459 |
| TCEB3CL | 0.459 |
| VASN | 0.457 |
| TBC1D3C | 0.456 |
| RPS7 | 0.456 |
| RPS19 | 0.454 |
| CBWD6 | 0.454 |
| PSMC1 | 0.454 |
| CHAF1A | 0.454 |
| CDC73 | 0.453 |
| POLA2 | 0.452 |
| GOLGA6L4 | 0.451 |
| CWC22 | 0.45 |
| ABHD8 | 0.45 |
| RPS6 | 0.448 |
| EBNA1BP2 | 0.448 |
| LRR1 | 0.448 |
| RPS9 | 0.445 |
| SF3A1 | 0.445 |
| PSMA1 | 0.445 |
| PSMA7 | 0.445 |
| NOC4L | 0.444 |
| PWP2 | 0.443 |
| HIST2H3C | 0.442 |
| HIST2H3A | 0.442 |
| RPS10 | 0.441 |
| PSMD6 | 0.44 |
| NPIPB8 | 0.44 |
| PSMC2 | 0.437 |
| CCDC116 | 0.435 |
| KRT78 | 0.435 |
| SF3A3 | 0.435 |
| RPS14 | 0.434 |
| EXOSC5 | 0.433 |
| NPIPB5 | 0.433 |
| CKAP5 | 0.432 |
| CDC45 | 0.432 |
| C1QTNF9B | 0.432 |
| S1PR4 | 0.43 |
| RPL14 | 0.43 |
| GOLGA6L1 | 0.429 |
| TICRR | 0.429 |
| RPS19BP1 | 0.427 |
| NUPL1 | 0.427 |
| PDE4DIP | 0.427 |
| AQR | 0.427 |
| SUPT6H | 0.426 |
| NOB1 | 0.425 |
| HEATR1 | 0.425 |
| PSMD3 | 0.425 |
| TSG101 | 0.424 |
| RPL30 | 0.424 |
| RPL6 | 0.424 |
| LAD1 | 0.423 |
| MDM2 | 0.423 |
| ORC1 | 0.423 |
| PPAN | 0.421 |
| PSMC6 | 0.421 |
| SLC4A1 | 0.421 |
| ORC6 | 0.42 |
| CHCHD3 | 0.419 |
| KIAA0947 | 0.417 |
| PSMD1 | 0.417 |
| NOL10 | 0.417 |
| SAP30BP | 0.416 |
| HAP1 | 0.415 |
| KRT2 | 0.414 |
| PLA2G4F | 0.414 |
| INTS5 | 0.413 |
| KIF3C | 0.413 |
| EXOSC1 | 0.411 |
| RPS8 | 0.411 |
| RPL9 | 0.41 |
| NUP133 | 0.41 |
| NOL12 | 0.41 |
| UTP3 | 0.409 |
| MT1E | 0.409 |
| ADRM1 | 0.409 |
| COPG1 | 0.409 |
| NCAPG | 0.409 |
| COL2A1 | 0.409 |
| GOLGA8J | 0.408 |
| OSBP | 0.408 |
| PAN2 | 0.408 |
| ZNF830 | 0.408 |
| ANKLE2 | 0.408 |
| TPX2 | 0.407 |
| POLE | 0.407 |
| COPE | 0.407 |
| TWISTNB | 0.407 |
| ZNF574 | 0.406 |
| NSF | 0.406 |
| EIF4A3 | 0.405 |
| AHCTF1 | 0.405 |
| CACTIN | 0.404 |
| DIDO1 | 0.404 |
| UTP6 | 0.404 |
| NUP98 | 0.404 |
| TAF15 | 0.404 |
| CEP192 | 0.404 |
| XAB2 | 0.403 |
| INCENP | 0.403 |
| C3orf17 | 0.403 |
| BRD2 | 0.403 |
| CMYA5 | 0.402 |
| UQCRH | 0.402 |
| PAF1 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 318/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 13/28 |
| blood | 7/28 |
| bone | 17/26 |
| breast | 12/33 |
| central nervous system | 24/56 |
| cervix | 1/4 |
| colorectal | 5/17 |
| esophagus | 3/13 |
| fibroblast | 1/1 |
| gastric | 3/16 |
| kidney | 10/21 |
| liver | 4/20 |
| lung | 34/75 |
| lymphocyte | 7/16 |
| ovary | 14/26 |
| pancreas | 10/24 |
| peripheral nervous system | 10/16 |
| plasma cell | 2/15 |
| prostate | 1/1 |
| skin | 13/24 |
| soft tissue | 6/9 |
| thyroid | 1/2 |
| upper aerodigestive | 8/22 |
| urinary tract | 11/29 |
| uterus | 4/5 |
Essentiality in NALM6
- Essentiality Rank: 392
- Expression level (log2 read counts): 8.83
Expression Distribution
RPS5 Expression in NALM6 Cells: 8.83
