DNTTIP2

Gene Information

Official Symbol: DNTTIP2
Official Name: deoxynucleotidyltransferase terminal interacting protein 2
Aliases and Previous Symbols: N/A
Entrez ID: 30836
UniProt: Q5QJE6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein. {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Oligomycin-A 20μM R00 exp26	-2.15
UM131593 0.2μM R03 exp106	-1.81
Fluvastatin 2.2μM R06 exp282	1.85
Menadione 5μM R06 exp292	1.93
Vinblastine 0.002μM R01 exp60	1.95
Colchicine 0.009μM R05 exp215	2.53
Calcipotriol 5μM R08 exp464	2.57

Gene	Correlation
PSMB2	0.563
ORC1	0.542
RPL35	0.514
OGFR	0.511
PSMB4	0.51
PSMD3	0.503
ZNF830	0.503
KCTD17	0.502
TBC1D3G	0.5
PSMC6	0.494
LRR1	0.493
TWISTNB	0.492
TBC1D3F	0.489
RPL37A	0.485
PSMA6	0.483
SYT9	0.482
NUPL1	0.481
RPS19BP1	0.481
CHD4	0.474
NBPF10	0.473
TBC1D3C	0.473
CACTIN	0.472
AKIRIN2	0.47
TFIP11	0.47
HIST1H2BE	0.469
SLC4A1	0.468
PSMD1	0.467
COPE	0.466
TBC1D3	0.466
C1QTNF9B	0.465
ATP6V1C1	0.465
PRIM1	0.463
NOL10	0.46
CBWD3	0.459
POLR2A	0.458
RRN3	0.458
TBC1D3H	0.457
VASN	0.457
AQR	0.457
ZNF106	0.454
SEL1L	0.453
PIGS	0.453
MED17	0.452
ARHGEF35	0.451
GOLGA6A	0.448
RPS12	0.447
FBXW9	0.447
CDC6	0.446
ORC6	0.444
IK	0.444
DTL	0.444
SMG1	0.444
MED14	0.443
PPFIA4	0.443
TCEB3C	0.443
COPB1	0.442
PSMD7	0.442
DDX23	0.442
CIAPIN1	0.442
ZNF655	0.439
COL2A1	0.438
POLE	0.437
RIOK2	0.437
NUP205	0.437
TOP1MT	0.436
TBC1D3E	0.435
TBC1D3I	0.435
PSMD11	0.435
HAP1	0.434
TBC1D3L	0.434
NUP153	0.434
TBC1D3K	0.434
LOC643669	0.433
ANKLE1	0.433
SUPT6H	0.432
RPL34	0.432
MFSD12	0.431
CDCA3	0.431
UBAP1	0.431
TYMS	0.43
PBXIP1	0.43
SLC38A7	0.43
GAR1	0.429
EXOSC9	0.429
CBWD5	0.429
MYLK3	0.429
TCEB3CL	0.428
GOLGA8J	0.426
COPG1	0.426
PAN3	0.425
CBWD6	0.425
TCEB3CL2	0.424
ZFAND5	0.424
PRPF8	0.424
CDC73	0.423
BCL2L1	0.422
PSMC1	0.42
CHAF1A	0.419
XYLT2	0.417
RPS7	0.417
PWP2	0.416
DOCK6	0.416
MSH5	0.416
DDTL	0.415
PSMB1	0.414
GID4	0.414
ADRA1D	0.413
UPF1	0.413
PAN2	0.412
RPS28	0.412
NUP133	0.412
C14orf93	0.411
CKAP5	0.411
RANBP2	0.411
SLC6A17	0.411
GPX4	0.411
SUPT5H	0.41
S1PR4	0.41
PSMD6	0.41
RRP15	0.409
RUVBL2	0.409
CLN6	0.409
NUP85	0.409
TSPY8	0.408
NPIPB5	0.408
TICRR	0.407
ADD2	0.407
ATP6V1B2	0.407
TP53TG3	0.406
TP53TG3C	0.406
TP53TG3B	0.406
POLR2J3	0.405
XAB2	0.405
KRT78	0.405
SEC13	0.405
RPL6	0.404
TIMELESS	0.404
CHMP2A	0.404
SNRPA1	0.403
RRP7A	0.403
LIPE	0.403
FAM160A1	0.402
MAU2	0.402
IGFN1	0.402
PSMD2	0.401
SLC5A5	0.401
GOLGA6L3	0.4
BYSL	0.4
TERF2	0.4

Global Fraction of Cell Lines Where Essential: 7/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	1/20
lung	1/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1745
Expression level (log2 read counts): 7.07

Expression Distribution

nucleolus
RNA binding