DR1

Gene Information

Official Symbol: DR1
Official Name: down-regulator of transcription 1
Aliases and Previous Symbols: N/A
Entrez ID: 1810
UniProt: Q01658
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:8670811}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cycloheximide 0.2μM R00 exp15	-1.93
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.79
Tubastatin-A 2.5μM R07 exp417	-1.79
Milciclib 2μM R08 exp502	1.72
Hinokiflavone 12μM R08 exp487	1.74
iCRT14 30μM R08 exp492	1.75
Aphidicolin 0.4μM R08 exp440	1.8
Cryptotanshinone 12μM R05 exp227	1.81
Latrunculin-B 10μM R07 exp374	1.81
GSK626616 14μM R08 exp485	1.92
BI-6727 0.04μM R03 exp98	1.95
Artemisinin 50μM R08 exp450	2.05
Deferoxamine 11μM R07 exp350	2.15
Doxorubicin 0.02μM R08 exp478	2.3
Bleomycin 5μM R08 exp459	2.32

Gene	Correlation
THG1L	0.672
RPTOR	0.565
TSEN54	0.554
ORAOV1	0.551
ATXN10	0.548
DOHH	0.544
ALG1	0.543
RPP21	0.531
PPP6C	0.531
UAP1	0.522
ADSL	0.522
GTF3C3	0.518
SRP14	0.511
MED16	0.509
GMPPB	0.509
ATIC	0.503
RTCB	0.5
WDR24	0.497
GTF3C6	0.494
BTAF1	0.493
NAE1	0.493
DPAGT1	0.493
VHL	0.491
PMM2	0.49
RNMT	0.486
GFPT1	0.486
TEN1	0.485
C15orf41	0.484
GEMIN7	0.483
TRMT61A	0.476
FH	0.473
GNB1L	0.473
GEMIN8	0.471
BAP1	0.47
PPCS	0.469
ALG13	0.467
GEMIN6	0.466
VEZT	0.464
EXOC4	0.464
PELO	0.463
TRNT1	0.462
URM1	0.462
TTI2	0.461
SSB	0.459
ELP3	0.458
BAK1	0.458
UHRF1	0.457
RPIA	0.457
TRIAP1	0.457
TBCB	0.455
UBE2M	0.454
UBA3	0.454
TTC4	0.452
GTF3C4	0.45
SLC25A19	0.448
TPK1	0.446
ENY2	0.445
TRIM28	0.444
WDR59	0.444
FBXO11	0.441
DDX1	0.44
LSM10	0.44
OIP5	0.438
SLC25A26	0.438
TSEN34	0.438
PPP2R3C	0.437
SNAPC5	0.437
HAUS8	0.436
N6AMT1	0.436
RABGGTB	0.435
RFK	0.432
MOCS3	0.432
KCTD5	0.432
MSTO1	0.43
KDSR	0.427
LAMTOR5	0.427
MED4	0.425
TXNRD1	0.425
UBE2G2	0.425
ATP5J	0.424
DHPS	0.424
PTAR1	0.423
TTI1	0.423
DOLK	0.422
ATP5B	0.422
NSD1	0.421
PLAA	0.42
WDR92	0.42
HCCS	0.419
CASP9	0.419
UXT	0.419
RFT1	0.418
ZZZ3	0.417
ALG2	0.416
TELO2	0.416
LSM11	0.416
HSPD1	0.415
EEF1E1	0.415
DDX55	0.415
WDR1	0.415
DRAP1	0.412
ROMO1	0.412
CTC1	0.411
MED23	0.409
EIF4E	0.408
DDOST	0.408
MTOR	0.408
ID3	0.408
MLLT1	0.406
TRIP12	0.404
AASDHPPT	0.404
POLR3H	0.403
GTF3A	0.402
ELP2	0.402

Global Fraction of Cell Lines Where Essential: 159/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	8/28
blood	7/28
bone	4/25
breast	4/33
central nervous system	13/56
cervix	0/4
colorectal	4/17
esophagus	2/13
fibroblast	1/1
gastric	3/15
kidney	4/21
liver	3/20
lung	16/75
lymphocyte	3/14
ovary	6/26
pancreas	8/24
peripheral nervous system	1/16
plasma cell	10/15
prostate	0/1
skin	9/24
soft tissue	0/7
thyroid	1/2
upper aerodigestive	4/22
urinary tract	13/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2385
Expression level (log2 read counts): 6.96

Expression Distribution

negative cofactor 2 complex
core promoter binding
regulation of RNA polymerase II transcriptional preinitiation complex assembly
Ada2/Gcn5/Ada3 transcription activator complex
TBP-class protein binding
regulation of transcription initiation from RNA polymerase II promoter
regulation of DNA-templated transcription, initiation
histone H3 acetylation
histone acetylation
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
protein acetylation
chromatin remodeling
protein acylation
transcription corepressor activity
transcription coactivator activity
peptidyl-lysine modification
transcription factor binding
histone modification
covalent chromatin modification
regulation of protein complex assembly
protein heterodimerization activity
chromatin organization
negative regulation of transcription by RNA polymerase II
peptidyl-amino acid modification
regulation of cellular component biogenesis
chromosome organization
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process