AATF

Gene Information

Official Symbol: AATF
Official Name: apoptosis antagonizing transcription factor
Aliases and Previous Symbols: N/A
Entrez ID: 26574
UniProt: Q9NY61
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MLN-4924 2μM R00 exp22	-2.44
Rotenone 2μM R00 exp33	-2.32
Etoposide 1μM R00 exp19	-2.26
Nocodazole 0.2μM R00 exp24	-2.19
Pimelic-diphenylamide-106 5μM R00 exp28	-2.08
Palbociclib 1μM R07 exp382	-1.9
Dorsomorphin 5μM R07 exp357	-1.84
Genistein 15μM R07 exp360	-1.79
Oligomycin-A 20μM R00 exp26	-1.77
Brefeldin A 0.02μM R00 exp8	-1.75
proTAME 5μM R04 exp187	1.7
A-395 10μM R05 exp218	1.73
Isonicotinamide 500μM R03 exp129	1.75
BAY-598 4μM R05 exp220	1.76
GSK626616 14μM R08 exp485	1.78
GSK2606414 1μM R05 exp236	1.79
Rifampicin 30μM R08 exp430	1.86
NFN1 0.1μM R01 exp49	1.89
Docetaxel 0.002μM R01 exp45	1.92
JQ1 0.01μM R03 exp130	1.96
CB-839 10μM R05 exp224	2.03
Myriocin 25μM R06 exp293	2.13

Gene	Correlation
POLR2J3	0.63
PSMB4	0.578
PRIM1	0.575
TCEB3CL	0.564
TCEB3C	0.559
TYMS	0.551
GOLGA6L1	0.526
CHD4	0.522
IK	0.519
TAF1	0.519
VPS28	0.518
CCNA2	0.517
PSMA6	0.515
RRP7A	0.511
EXOSC8	0.509
ATP6V1A	0.507
TCEB3CL2	0.5
SUPT5H	0.498
POLE	0.493
ATP6V1B2	0.493
DISP2	0.488
RPS12	0.486
COPG1	0.485
COX7A2L	0.485
PSMB2	0.484
SLC4A1	0.483
AQR	0.481
ATP6V0C	0.481
ORC1	0.48
PAN2	0.478
PSMC2	0.477
RPL9	0.475
TSPY8	0.475
POLR2D	0.472
TFIP11	0.472
CBWD3	0.471
HIVEP3	0.471
TWISTNB	0.471
WDR75	0.469
RPL35	0.466
TBC1D3F	0.466
CDC45	0.465
TBC1D3H	0.463
SLC6A17	0.463
POLR2A	0.461
DHX38	0.46
SULT1A4	0.46
SULT1A3	0.46
TICRR	0.458
GID4	0.456
TP53TG3B	0.455
TP53TG3C	0.455
TP53TG3	0.455
TBC1D3	0.455
PSMB1	0.454
DTL	0.454
CBWD5	0.454
POLR1A	0.453
NARFL	0.452
NOL12	0.451
RPS2	0.451
AKT1S1	0.45
UTP3	0.448
PSMD3	0.447
CACTIN	0.447
GOLGA6L3	0.445
RPS19	0.445
UPF1	0.444
MED14	0.444
RPL6	0.443
GAR1	0.443
RPS7	0.443
OGFR	0.442
OSBP	0.442
SMTN	0.441
NPIPB5	0.44
NFATC4	0.438
CBWD6	0.438
DDTL	0.438
ORC6	0.437
PIGS	0.437
SMG1	0.433
GOLGA6L4	0.433
ANKLE1	0.432
SLC38A7	0.432
CTAGE4	0.432
TP53TG3D	0.432
SNIP1	0.43
VPS54	0.43
COL2A1	0.429
KRT78	0.429
CHCHD3	0.428
SCGB1C1	0.427
UTP20	0.426
SUPT6H	0.425
SH3BP1	0.425
TBC1D3G	0.425
TRAPPC8	0.425
RAD51	0.424
RIOK2	0.424
RRN3	0.424
DDX56	0.422
RANBP2	0.422
TBC1D3C	0.421
MTCH2	0.421
PSMA3	0.42
GOLGA6L6	0.42
COPA	0.42
SKIV2L2	0.419
GOLGA6B	0.419
C1QTNF9B	0.419
PSMA7	0.417
RPL30	0.416
RNPC3	0.415
CEP192	0.414
FAM25B	0.414
COPZ1	0.414
PSMD11	0.414
ATP6V1C1	0.413
RPS19BP1	0.413
TBC1D3I	0.412
TBC1D3E	0.412
FAM160A1	0.412
CHAF1A	0.411
CHMP4B	0.411
COPB1	0.411
TBC1D3K	0.411
TBC1D3L	0.411
MYB	0.41
CDCA3	0.409
LRR1	0.409
NUP160	0.407
TSPY2	0.407
TIMELESS	0.407
NOL10	0.407
SULT2B1	0.406
NOC4L	0.405
TTC1	0.405
XAB2	0.405
GOLGA6A	0.404
PSMC1	0.404
ZNF830	0.404
GON4L	0.404
RPLP0	0.404
SYT9	0.404
GBF1	0.403
CLN6	0.403
TSPY1	0.403
TRAPPC11	0.403
SAP30BP	0.401
S1PR4	0.401
NUPL1	0.401
AAMP	0.4

Global Fraction of Cell Lines Where Essential: 20/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	2/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	2/75
lymphocyte	1/16
ovary	1/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 999
Expression level (log2 read counts): 6.33

Expression Distribution

negative regulation of superoxide anion generation
negative regulation of amyloid precursor protein biosynthetic process
embryonic cleavage
leucine zipper domain binding
regulation of amyloid precursor protein biosynthetic process
negative regulation of glycoprotein biosynthetic process
negative regulation of glycoprotein metabolic process
regulation of superoxide anion generation
regulation of superoxide metabolic process
regulation of glycoprotein biosynthetic process
regulation of glycoprotein metabolic process
tau protein binding
negative regulation of reactive oxygen species metabolic process
regulation of reactive oxygen species metabolic process
ribosome biogenesis
ribonucleoprotein complex biogenesis
protein kinase binding
cell division
regulation of mitotic cell cycle
cellular response to DNA damage stimulus
nucleolus
negative regulation of apoptotic process
negative regulation of programmed cell death
cell adhesion
biological adhesion
embryo development
Golgi apparatus
negative regulation of cell death
negative regulation of protein metabolic process
regulation of cell cycle
positive regulation of transcription by RNA polymerase II
negative regulation of cellular macromolecule biosynthetic process
RNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
regulation of apoptotic process
negative regulation of biosynthetic process
regulation of programmed cell death
positive regulation of nucleic acid-templated transcription