CCDC94
Gene Information
- Official Symbol: YJU2
- Official Name: YJU2 splicing factor homolog
- Aliases and Previous Symbols: N/A
- Entrez ID: 55702
- UniProt: Q9BW85
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: N/A
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| DUF572 |
GO Terms
| U2-type catalytic step 1 spliceosome |
| negative regulation of DNA damage response, signal transduction by p53 class mediator |
| negative regulation of signal transduction by p53 class mediator |
| regulation of DNA damage response, signal transduction by p53 class mediator |
| negative regulation of response to DNA damage stimulus |
| regulation of signal transduction by p53 class mediator |
| regulation of response to DNA damage stimulus |
| RNA splicing |
| mRNA processing |
| negative regulation of intracellular signal transduction |
| mRNA metabolic process |
| regulation of cellular response to stress |
| RNA processing |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of response to stress |
| negative regulation of response to stimulus |
| RNA metabolic process |
| regulation of intracellular signal transduction |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| TCEB3CL2 | 0.557 |
| TBC1D3G | 0.531 |
| POLR2J3 | 0.527 |
| TCEB3CL | 0.519 |
| TBC1D3H | 0.517 |
| TBC1D3F | 0.505 |
| HAP1 | 0.504 |
| TBC1D3I | 0.502 |
| TBC1D3E | 0.502 |
| TBC1D3K | 0.501 |
| TBC1D3L | 0.501 |
| TCEB3C | 0.498 |
| TBC1D3 | 0.497 |
| HIST1H2BE | 0.49 |
| PSMD1 | 0.49 |
| TICRR | 0.488 |
| C1QTNF9B | 0.487 |
| TBC1D3C | 0.482 |
| AKIRIN2 | 0.471 |
| PLK4 | 0.471 |
| CWC22 | 0.47 |
| C14orf93 | 0.468 |
| PSMB4 | 0.466 |
| PSMD3 | 0.465 |
| STIL | 0.465 |
| RPL34 | 0.459 |
| RRP15 | 0.458 |
| CHD4 | 0.456 |
| ORC1 | 0.455 |
| PSMC6 | 0.453 |
| RAD51 | 0.453 |
| PSMD11 | 0.452 |
| COPE | 0.451 |
| VASN | 0.451 |
| LRR1 | 0.448 |
| TFIP11 | 0.448 |
| ZNF830 | 0.448 |
| PCF11 | 0.447 |
| MYO18A | 0.447 |
| COPA | 0.446 |
| MT1E | 0.444 |
| CCNA2 | 0.44 |
| SF3A1 | 0.439 |
| SYT9 | 0.439 |
| CWC15 | 0.436 |
| SUPT6H | 0.434 |
| WDR87 | 0.434 |
| NDC1 | 0.433 |
| SNRPA1 | 0.433 |
| CDC45 | 0.432 |
| RRN3 | 0.431 |
| NUP43 | 0.43 |
| FAM25B | 0.429 |
| COPZ1 | 0.429 |
| MYO1H | 0.426 |
| PSMA6 | 0.426 |
| NUPL1 | 0.426 |
| LAD1 | 0.426 |
| WDR43 | 0.424 |
| PSMC5 | 0.424 |
| ZNF106 | 0.424 |
| FAM231A | 0.423 |
| AQR | 0.423 |
| GNB3 | 0.423 |
| FAM231C | 0.422 |
| CMYA5 | 0.421 |
| ARCN1 | 0.421 |
| RPS14 | 0.421 |
| SEL1L | 0.42 |
| CGB2 | 0.418 |
| RNF113A | 0.417 |
| TERF2 | 0.417 |
| TOP1MT | 0.417 |
| TWISTNB | 0.416 |
| EXOSC3 | 0.415 |
| ZFAND5 | 0.415 |
| NPIPB5 | 0.415 |
| DDTL | 0.414 |
| MED29 | 0.413 |
| SART1 | 0.41 |
| IK | 0.409 |
| HIVEP3 | 0.409 |
| ZNF655 | 0.409 |
| PSMC2 | 0.409 |
| SLC4A1 | 0.407 |
| CBWD3 | 0.407 |
| CKAP5 | 0.407 |
| RPS9 | 0.407 |
| INTS6 | 0.406 |
| RANBP2 | 0.406 |
| NSF | 0.405 |
| PSMB1 | 0.405 |
| FCN2 | 0.405 |
| RPL35 | 0.405 |
| RNF4 | 0.404 |
| CDC73 | 0.404 |
| RPS2 | 0.404 |
| TGFBRAP1 | 0.404 |
| PAN2 | 0.403 |
| RAD21 | 0.402 |
| TSPY8 | 0.402 |
| MYB | 0.402 |
| CEP192 | 0.401 |
| MAT2A | 0.401 |
| ANKLE2 | 0.401 |
| COX8A | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 729/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 28/28 |
| bone | 26/26 |
| breast | 31/33 |
| central nervous system | 56/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 12/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 20/21 |
| liver | 20/20 |
| lung | 75/75 |
| lymphocyte | 16/16 |
| ovary | 26/26 |
| pancreas | 23/24 |
| peripheral nervous system | 15/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 22/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 28/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 60
- Expression level (log2 read counts): 3.71
Expression Distribution
CCDC94 Expression in NALM6 Cells: 3.71
