COQ3

Entrez Summary: N/A
UniProt Summary: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. {ECO:0000255|HAMAP- Rule:MF_03190}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hydroxyurea 15μM R06 exp289	1.75
Benzoate 20000μM R08 exp456	1.81
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.9
Thimerosal 0.85μM R08 exp529	2.03
Quercetin 20μM R08 exp517	2.11
Aphidicolin 0.4μM R08 exp440	2.44
Ammonium tetrathiomolybdate 10μM R08 exp448	2.68

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

3-demethylubiquinone-9 3-O-methyltransferase activity
2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
hexaprenyldihydroxybenzoate methyltransferase activity
decaprenyldihydroxybenzoate methyltransferase activity
3-demethylubiquinone-10 3-O-methyltransferase activity
3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity
regulation of ubiquinone biosynthetic process
O-methyltransferase activity
regulation of coenzyme metabolic process
extrinsic component of mitochondrial inner membrane
quinone biosynthetic process
regulation of ketone biosynthetic process
ubiquinone biosynthetic process
ubiquinone metabolic process
glycerol metabolic process
alditol metabolic process
ketone biosynthetic process
quinone metabolic process
regulation of cofactor metabolic process
oxidoreduction coenzyme metabolic process
cellular ketone metabolic process
polyol metabolic process
coenzyme biosynthetic process
cellular carbohydrate metabolic process
regulation of cellular ketone metabolic process
cofactor biosynthetic process
coenzyme metabolic process
methylation
alcohol metabolic process
mitochondrial matrix
regulation of small molecule metabolic process
cofactor metabolic process
organic hydroxy compound metabolic process
carbohydrate metabolic process
small molecule biosynthetic process
mitochondrion
small molecule metabolic process