TOMM20
Gene Information
- Official Symbol: TOMM20
- Official Name: translocase of outer mitochondrial membrane 20
- Aliases and Previous Symbols: N/A
- Entrez ID: 9804
- UniProt: Q15388
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| MAS20 |
GO Terms
| tRNA import into mitochondrion |
| mitochondrial outer membrane translocase complex assembly |
| response to 3,3,5-triiodo-L-thyronine |
| mitochondrion targeting sequence binding |
| RNA import into mitochondrion |
| outer mitochondrial membrane organization |
| P-P-bond-hydrolysis-driven protein transmembrane transporter activity |
| mitochondrial outer membrane translocase complex |
| mitochondria-associated endoplasmic reticulum membrane |
| protein transmembrane transporter activity |
| protein import into mitochondrial matrix |
| integral component of mitochondrial outer membrane |
| response to muscle activity |
| response to thyroid hormone |
| protein transmembrane import into intracellular organelle |
| tRNA transport |
| intracellular protein transmembrane transport |
| protein targeting to mitochondrion |
| protein transmembrane transport |
| response to activity |
| establishment of protein localization to mitochondrion |
| protein localization to mitochondrion |
| mitochondrial transmembrane transport |
| response to amino acid |
| mitochondrial membrane organization |
| unfolded protein binding |
| protein import |
| macroautophagy |
| mitochondrial outer membrane |
| RNA transport |
| nucleic acid transport |
| establishment of RNA localization |
| mitochondrial transport |
| RNA localization |
| nucleobase-containing compound transport |
| autophagy |
| process utilizing autophagic mechanism |
| protein deubiquitination |
| protein modification by small protein removal |
| response to acid chemical |
| protein targeting |
| establishment of protein localization to organelle |
| mitochondrion organization |
| protein localization to organelle |
| cellular protein-containing complex assembly |
| membrane organization |
| response to hormone |
| response to organic cyclic compound |
| protein modification by small protein conjugation or removal |
| intracellular protein transport |
| response to organonitrogen compound |
| response to nitrogen compound |
| mitochondrion |
| proteolysis |
| transmembrane transport |
| response to endogenous stimulus |
| protein transport |
| intracellular transport |
| peptide transport |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Hydroxyurea 100μM R07 exp329 | 1.71 |
| UM0125461 0.74μM R02 exp84 | 1.75 |
| Artemisinin 50μM R08 exp450 | 2.03 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| YARS2 | 0.61 |
| MRPS21 | 0.589 |
| MRPS16 | 0.588 |
| MRPL21 | 0.582 |
| RBFA | 0.58 |
| HSD17B10 | 0.574 |
| VARS2 | 0.562 |
| MRPS34 | 0.562 |
| TARS2 | 0.554 |
| MIPEP | 0.552 |
| RPUSD4 | 0.548 |
| QRSL1 | 0.543 |
| EARS2 | 0.54 |
| MRPL23 | 0.533 |
| MRPS5 | 0.532 |
| DAP3 | 0.53 |
| MARS2 | 0.528 |
| GFM1 | 0.528 |
| MRP63 | 0.525 |
| MRPS12 | 0.523 |
| GTPBP10 | 0.522 |
| MRPS26 | 0.522 |
| MRPS6 | 0.518 |
| NARS2 | 0.517 |
| SCO2 | 0.516 |
| MRPS14 | 0.516 |
| NDUFB11 | 0.515 |
| MRPL53 | 0.514 |
| IBA57 | 0.512 |
| AARS2 | 0.506 |
| NDUFAF7 | 0.505 |
| RNASEH1 | 0.505 |
| SELRC1 | 0.504 |
| RARS2 | 0.503 |
| POLG2 | 0.496 |
| MRPS22 | 0.495 |
| COA3 | 0.493 |
| FTSJ2 | 0.492 |
| MRPL47 | 0.492 |
| PET112 | 0.491 |
| TOMM40 | 0.49 |
| LARS2 | 0.489 |
| DARS2 | 0.489 |
| NDUFA3 | 0.489 |
| KIAA0391 | 0.487 |
| MRPS9 | 0.485 |
| SARS2 | 0.482 |
| MRPL11 | 0.481 |
| TUFM | 0.479 |
| MRPL15 | 0.477 |
| MRPS18A | 0.476 |
| MRPS11 | 0.476 |
| AIFM1 | 0.473 |
| C12orf65 | 0.47 |
| MRPL33 | 0.469 |
| MTG2 | 0.468 |
| PARS2 | 0.467 |
| MRPS2 | 0.467 |
| MRPL45 | 0.464 |
| UQCC2 | 0.458 |
| COX16 | 0.457 |
| MRPS25 | 0.455 |
| MTRF1L | 0.454 |
| TRUB2 | 0.454 |
| POLRMT | 0.452 |
| NDUFS2 | 0.451 |
| ERAL1 | 0.451 |
| TEFM | 0.45 |
| BCS1L | 0.45 |
| SUPV3L1 | 0.45 |
| C10orf2 | 0.449 |
| MRPS33 | 0.449 |
| ACAD9 | 0.449 |
| MRPL12 | 0.448 |
| MRPL39 | 0.448 |
| FASTKD5 | 0.448 |
| C17orf89 | 0.448 |
| MTG1 | 0.446 |
| MALSU1 | 0.445 |
| GATC | 0.444 |
| MRPS10 | 0.443 |
| TMEM261 | 0.443 |
| GFM2 | 0.443 |
| RPUSD3 | 0.442 |
| PET117 | 0.441 |
| NDUFB6 | 0.44 |
| NDUFAF3 | 0.436 |
| ELAC2 | 0.435 |
| ECSIT | 0.434 |
| MRPL35 | 0.434 |
| WARS2 | 0.434 |
| NDUFA2 | 0.431 |
| DDX28 | 0.43 |
| GLRX5 | 0.427 |
| WBSCR16 | 0.427 |
| UQCRC2 | 0.424 |
| CHCHD1 | 0.424 |
| TOMM6 | 0.424 |
| HARS2 | 0.422 |
| COQ3 | 0.422 |
| RNMTL1 | 0.422 |
| POLG | 0.422 |
| TFAM | 0.422 |
| MRPL43 | 0.421 |
| MRPL34 | 0.421 |
| MRPS24 | 0.421 |
| MRPL49 | 0.421 |
| C1QBP | 0.421 |
| MTPAP | 0.421 |
| COQ2 | 0.42 |
| MRPL3 | 0.42 |
| COA6 | 0.419 |
| METTL17 | 0.418 |
| COX11 | 0.418 |
| PPCS | 0.417 |
| COX17 | 0.415 |
| MRPL4 | 0.415 |
| ATP5SL | 0.415 |
| MCAT | 0.414 |
| COX15 | 0.414 |
| TPK1 | 0.414 |
| GRSF1 | 0.414 |
| FARS2 | 0.414 |
| COX6C | 0.412 |
| NDUFA1 | 0.41 |
| MRPL22 | 0.41 |
| MRPL44 | 0.41 |
| MRPL41 | 0.409 |
| MRPS35 | 0.408 |
| TRMT10C | 0.408 |
| MRPL18 | 0.407 |
| TFB2M | 0.407 |
| NDUFC2 | 0.406 |
| PITRM1 | 0.405 |
| TOMM22 | 0.404 |
| NUBPL | 0.404 |
| PNPT1 | 0.403 |
| MRPS23 | 0.402 |
| TIMM8B | 0.402 |
| MTERFD2 | 0.401 |
| TRMT61A | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 288/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 1/1 |
| bile duct | 8/28 |
| blood | 17/28 |
| bone | 14/26 |
| breast | 8/33 |
| central nervous system | 26/56 |
| cervix | 2/4 |
| colorectal | 7/17 |
| esophagus | 3/13 |
| fibroblast | 1/1 |
| gastric | 9/16 |
| kidney | 6/21 |
| liver | 4/20 |
| lung | 24/75 |
| lymphocyte | 2/16 |
| ovary | 5/26 |
| pancreas | 8/24 |
| peripheral nervous system | 2/16 |
| plasma cell | 9/15 |
| prostate | 1/1 |
| skin | 8/24 |
| soft tissue | 3/9 |
| thyroid | 2/2 |
| upper aerodigestive | 11/22 |
| urinary tract | 15/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 611
- Expression level (log2 read counts): 8.1
Expression Distribution
TOMM20 Expression in NALM6 Cells: 8.1
