MRPL12

Gene Information

Official Symbol: MRPL12
Official Name: mitochondrial ribosomal protein L12
Aliases and Previous Symbols: N/A
Entrez ID: 6182
UniProt: P52815
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Associates with mitochondrial RNA polymerase to activate transcription. {ECO:0000269|PubMed:22003127}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Metformin 100 to 150μM on day4 R04 exp170	-1.89
Nutlin-3A 1.6μM R06 exp294	1.75
Hydroxyurea 100μM R07 exp329	1.9
Bafilomycin-A1 0.009μM R08 exp454	1.92
Genistein 15μM R07 exp360	1.95
iCRT14 30μM R08 exp492	1.96
CR131-b 0.005μM R08 exp474	1.98
Thimerosal 0.85μM R08 exp529	2.33
GSK-J4 1.5μM R08 exp441	2.37

Gene	Correlation
MRPS5	0.667
YARS2	0.644
TARS2	0.638
NARS2	0.626
MRPL53	0.611
MRPL21	0.605
RPUSD4	0.602
SELRC1	0.601
HSD17B10	0.6
MRPS21	0.598
MRPL23	0.594
GFM1	0.592
DAP3	0.591
MRP63	0.588
MRPS18A	0.585
TEFM	0.585
MRPS14	0.584
VARS2	0.581
PARS2	0.578
MRPL3	0.576
FTSJ2	0.575
MRPS34	0.573
MRPS6	0.571
RNASEH1	0.565
FASTKD5	0.561
QRSL1	0.557
RBFA	0.555
GTPBP10	0.553
GATC	0.553
SARS2	0.549
MRPS16	0.549
EARS2	0.548
MRPS9	0.546
NDUFB11	0.545
MRPS10	0.538
MRPL45	0.535
MRPS35	0.533
SCO2	0.533
LARS2	0.53
MRPL47	0.53
MRPS2	0.527
NDUFA3	0.525
PET112	0.522
MTG1	0.521
MTG2	0.52
MRPS24	0.519
MRPS26	0.518
MTPAP	0.515
WBSCR16	0.514
RARS2	0.514
MRPL55	0.514
KIAA0391	0.51
SUPV3L1	0.51
MARS2	0.509
POLG2	0.509
GFM2	0.506
MRPS7	0.506
PDSS1	0.505
DARS2	0.505
BCS1L	0.503
MRPS25	0.499
COX16	0.497
COA3	0.497
MIPEP	0.494
HARS2	0.491
C12orf65	0.489
NDUFAF7	0.484
DHX30	0.484
AARS2	0.484
HMGXB3	0.483
C10orf2	0.483
MRPL42	0.483
PNPT1	0.482
TRUB2	0.481
POLG	0.48
FARS2	0.48
IBA57	0.477
C17orf89	0.474
TUFM	0.47
COQ2	0.468
MTERFD2	0.468
GTPBP6	0.468
NDUFB5	0.467
MRPL15	0.466
TMEM242	0.465
METTL17	0.462
MRPS12	0.462
TFAM	0.462
MRPL2	0.461
MRPL20	0.461
MRPL43	0.46
UQCR10	0.458
MRPL38	0.458
NDUFA2	0.457
NDUFS7	0.456
NDUFC2	0.456
MRPL36	0.453
ELAC2	0.452
TIMM8B	0.452
POLRMT	0.451
MRPS22	0.451
COA6	0.45
SLC25A26	0.45
TOMM20	0.448
FOXRED1	0.446
COX6C	0.445
MRPL18	0.443
MRPL41	0.44
COQ7	0.438
MRPL33	0.438
ATP5SL	0.438
MRPL46	0.438
COX11	0.437
GRSF1	0.437
NDUFB6	0.436
NDUFS2	0.436
MRPL13	0.435
MRPS33	0.435
NDUFA1	0.433
MRPL4	0.432
MTRF1L	0.431
COX7B	0.429
MRPL34	0.429
NDUFA11	0.426
RPUSD3	0.425
ECSIT	0.425
MRPL11	0.423
TOMM40	0.423
SSBP1	0.423
CHCHD1	0.421
ACAD9	0.421
COQ3	0.421
NDUFAF5	0.42
DDX28	0.417
FASTKD2	0.416
NDUFB3	0.415
CHCHD4	0.415
MRPS17	0.413
MRPL44	0.413
ATP5D	0.411
MRPL17	0.411
ATP5C1	0.409
WARS2	0.409
NDUFAF3	0.408
ERAL1	0.406
NDUFA8	0.406
MTIF3	0.406
CARS2	0.405
COX5A	0.404
AIFM1	0.404
MRPL37	0.403
MRPS27	0.403
DHRSX	0.403
MRPS23	0.402
MRPL22	0.402
PGM3	0.402
MTIF2	0.401
PET117	0.401
PTCD1	0.401

Global Fraction of Cell Lines Where Essential: 182/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	5/28
blood	6/28
bone	7/26
breast	14/33
central nervous system	8/56
cervix	3/4
colorectal	6/17
esophagus	5/13
fibroblast	0/1
gastric	5/16
kidney	4/21
liver	6/20
lung	22/75
lymphocyte	3/16
ovary	1/26
pancreas	5/24
peripheral nervous system	0/16
plasma cell	3/15
prostate	0/1
skin	4/24
soft tissue	4/9
thyroid	0/2
upper aerodigestive	5/22
urinary tract	6/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1270
Expression level (log2 read counts): 5.46

Expression Distribution