CEPT1
Gene Information
- Official Symbol: CEPT1
- Official Name: choline/ethanolamine phosphotransferase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 10390
- UniProt: Q9Y6K0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity. {ECO:0000269|PubMed:10191259, ECO:0000269|PubMed:10893425}.
Pfam Domains GO Terms
Pfam Domains
| CDP-OH P transf |
GO Terms
| diacylglycerol cholinephosphotransferase activity |
| ethanolaminephosphotransferase activity |
| phosphotransferase activity, for other substituted phosphate groups |
| CDP-choline pathway |
| phosphatidylethanolamine biosynthetic process |
| phosphatidylethanolamine metabolic process |
| phosphatidylcholine biosynthetic process |
| phosphatidylcholine metabolic process |
| ammonium ion metabolic process |
| glycerophospholipid biosynthetic process |
| glycerolipid biosynthetic process |
| nuclear membrane |
| phospholipid biosynthetic process |
| glycerophospholipid metabolic process |
| phospholipid metabolic process |
| glycerolipid metabolic process |
| organophosphate biosynthetic process |
| lipid biosynthetic process |
| organophosphate metabolic process |
| endoplasmic reticulum membrane |
| cellular lipid metabolic process |
| Golgi apparatus |
| lipid metabolic process |
| organonitrogen compound biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| FLVCR1 | 0.634 |
| CHKA | 0.569 |
| PTDSS1 | 0.536 |
| KDSR | 0.52 |
| PCYT1A | 0.491 |
| ATP2A2 | 0.484 |
| GFPT1 | 0.481 |
| ROMO1 | 0.474 |
| CTDNEP1 | 0.473 |
| PPA2 | 0.471 |
| DOHH | 0.465 |
| UAP1 | 0.465 |
| MBTPS1 | 0.461 |
| SPTLC2 | 0.454 |
| HCCS | 0.452 |
| KIAA1432 | 0.45 |
| DHRSX | 0.45 |
| THG1L | 0.447 |
| BAK1 | 0.446 |
| UBE2G2 | 0.445 |
| SCAP | 0.444 |
| ATP5A1 | 0.442 |
| RGP1 | 0.438 |
| C10orf2 | 0.433 |
| FAF2 | 0.431 |
| CNEP1R1 | 0.431 |
| PGM3 | 0.431 |
| VDAC2 | 0.43 |
| USO1 | 0.43 |
| APAF1 | 0.429 |
| OST4 | 0.428 |
| ALG5 | 0.425 |
| UQCRC2 | 0.425 |
| BCS1L | 0.421 |
| MBTPS2 | 0.417 |
| CYCS | 0.414 |
| FECH | 0.414 |
| SLC25A26 | 0.413 |
| PIK3R4 | 0.412 |
| ATXN10 | 0.411 |
| SRP14 | 0.408 |
| ATP5O | 0.403 |
| TAZ | 0.403 |
| PGS1 | 0.401 |
| TAMM41 | 0.401 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 18/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 2/26 |
| breast | 0/33 |
| central nervous system | 1/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 1/16 |
| ovary | 0/26 |
| pancreas | 2/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 3/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6903
- Expression level (log2 read counts): 5.99
Expression Distribution
CEPT1 Expression in NALM6 Cells: 5.99
