ACSF2

Gene Information

Official Symbol: ACSF2
Official Name: acyl-CoA synthetase family member 2
Aliases and Previous Symbols: N/A
Entrez ID: 80221
UniProt: Q96CM8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation. {ECO:0000269|PubMed:16380219, ECO:0000269|PubMed:17762044}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Brefeldin A 0.02μM R00 exp8	-1.86
DABN 20μM R00 exp17	-1.81
Nifuroxazide 5μM R03 exp102	1.74
Chloramphenicol 2μM R00 exp12	1.87
Caffeine 2600μM R08 exp463	1.9
Ibrutinib 1μM R07 exp372	1.91

Gene	Correlation
HGC6.3	0.647
RAD51	0.525
C2orf27B	0.52
CDC45	0.511
TFIP11	0.509
C1QTNF9B	0.506
ORC6	0.504
SNRPA1	0.498
TBC1D3H	0.498
XYLT2	0.495
DTL	0.495
SLC4A1	0.491
CCNA2	0.49
TBC1D3G	0.489
PSMA6	0.489
KCTD17	0.488
TCEB3C	0.487
CACTIN	0.483
PSMC2	0.483
RPS19BP1	0.482
TCEB3CL2	0.48
PSMB4	0.479
UTP3	0.479
SUPT5H	0.477
DDTL	0.475
PLA2G4F	0.475
MT1E	0.473
RPL35	0.472
NUPL1	0.471
RRN3	0.471
RPS5	0.47
COPG1	0.468
CCDC64B	0.465
TBC1D3F	0.464
TICRR	0.464
DOCK6	0.461
RRP7A	0.458
NFATC4	0.458
TCEB3CL	0.458
UPF1	0.457
ATP6V1C1	0.456
POLR2L	0.455
GOLGA6L3	0.455
COL2A1	0.454
TBC1D3C	0.453
ANKLE1	0.453
IK	0.453
CEBPZ	0.452
AHCTF1	0.451
PWP2	0.451
ZNF830	0.451
CBWD3	0.449
GAR1	0.448
LOC643669	0.448
NIPBL	0.447
NSF	0.444
CBWD5	0.444
TP53TG3	0.443
TP53TG3B	0.443
TP53TG3C	0.443
CDC73	0.442
FAM160A1	0.442
PSMB3	0.441
CHD4	0.441
VASN	0.441
POLE	0.44
SEC13	0.439
POLR2J3	0.439
TSPY8	0.438
NUP160	0.438
MYO1H	0.438
ANKLE2	0.435
ZNF574	0.435
TBC1D3E	0.435
TBC1D3I	0.435
TBC1D3K	0.434
ATXN1	0.434
TBC1D3L	0.434
DIDO1	0.434
ORC1	0.433
TBC1D3	0.433
SMG7	0.432
C14orf93	0.432
PSMC5	0.431
COPE	0.431
ZNF655	0.431
NPIPB5	0.43
PSMC1	0.43
CBWD6	0.429
LRR1	0.429
UBAP1	0.429
RPS9	0.429
NARFL	0.429
WDR87	0.429
RPS12	0.429
CHMP2A	0.428
PSMB2	0.428
CDC6	0.427
DDX56	0.427
INTS5	0.426
SSH2	0.426
RPS2	0.426
SAP30BP	0.424
ZFAND5	0.424
RPSA	0.423
OSBP	0.423
PSMD3	0.423
ISCU	0.423
GOLGA8O	0.422
INTS6	0.422
PDE4DIP	0.421
HIST2H2BF	0.421
STIL	0.418
TUBA8	0.418
POLA2	0.417
COPB1	0.415
RPS28	0.415
AAMP	0.415
CHAF1A	0.414
TWISTNB	0.413
EXOSC5	0.413
VPS54	0.412
CCDC116	0.412
RRP15	0.411
GOLGA6A	0.411
GOLGA6L4	0.411
RPS3A	0.41
PSMD14	0.41
OGFR	0.41
ARCN1	0.409
PSMD11	0.408
POLA1	0.408
HIST1H2BE	0.408
RPL9	0.407
CTAGE4	0.407
AKIRIN2	0.405
NOL7	0.405
CLN6	0.404
BRD2	0.404
KIF3C	0.404
DDX47	0.403
PSMA7	0.403
TIMELESS	0.402
COPA	0.402
SYT9	0.402
RPS21	0.401
CKAP5	0.401
C2orf27A	0.4
SNX15	0.4
AQR	0.4
RPLP1	0.4
PSMD7	0.4
HIVEP3	0.4
PAN3	0.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1893
Expression level (log2 read counts): 4.81

Expression Distribution

acyl-CoA ligase activity
acyl-CoA metabolic process
thioester metabolic process
nucleoside bisphosphate metabolic process
ribonucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process
coenzyme metabolic process
purine ribonucleotide metabolic process
fatty acid metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
sulfur compound metabolic process
purine-containing compound metabolic process
mitochondrial matrix
cofactor metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
monocarboxylic acid metabolic process
nucleobase-containing small molecule metabolic process
cellular amide metabolic process
organophosphate metabolic process
carboxylic acid metabolic process
cellular lipid metabolic process
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
lipid metabolic process
ATP binding
small molecule metabolic process