AHCTF1

Entrez Summary: N/A
UniProt Summary: Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 451/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	18/28
blood	22/28
bone	15/26
breast	20/33
central nervous system	30/56
cervix	2/4
colorectal	12/17
esophagus	3/13
fibroblast	1/1
gastric	9/16
kidney	10/21
liver	7/20
lung	53/75
lymphocyte	12/16
ovary	13/26
pancreas	17/24
peripheral nervous system	12/16
plasma cell	10/15
prostate	1/1
skin	11/24
soft tissue	6/9
thyroid	2/2
upper aerodigestive	8/22
urinary tract	12/29
uterus	3/5

Expression Distribution

nuclear pore complex assembly
nuclear pore outer ring
nuclear pore organization
pore complex assembly
nuclear pore
condensed chromosome kinetochore
regulation of cytokinesis
nuclear matrix
chromatin
nucleus organization
mRNA transport
regulation of cell division
nucleic acid transport
RNA transport
establishment of RNA localization
RNA localization
nuclear membrane
nucleobase-containing compound transport
cell division
regulation of cell cycle process
cellular protein-containing complex assembly
regulation of cell cycle
cell cycle
DNA binding
protein transport
peptide transport
protein-containing complex assembly
DNA-binding transcription factor activity, RNA polymerase II-specific
amide transport
establishment of protein localization
nitrogen compound transport
protein-containing complex subunit organization