MARCH5

Gene Information

Official Symbol: MARCHF5
Official Name: membrane associated ring-CH-type finger 5
Aliases and Previous Symbols: N/A
Entrez ID: 54708
UniProt: Q9NX47
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1. {ECO:0000269|PubMed:16874301, ECO:0000269|PubMed:17606867, ECO:0000269|PubMed:19741096, ECO:0000269|PubMed:20103533}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cerivastatin 0.15μM R05 exp226	-1.88
Mubritinib 0.2μM R01 exp48	1.71
BI-2536 0.001μM R01 exp41	1.72
Bortezomib 0.05μM R00 exp7	1.72
Citral 75μM R06 exp275	1.73
Trientine 500μM R08 exp534	1.73
DABN 20μM R00 exp17	1.76
Alpha-Amanitin 0.5μM R00 exp5	1.81
Ammonium tetrathiomolybdate 10μM R08 exp448	1.81
PU-H71 1μM R08 exp515	1.82
Thimerosal 0.85μM R08 exp529	1.82
Deferoxamine 11μM R07 exp350	1.86
LJH685 5μM R02 exp73	1.86
Etoposide 0.1μM R05 exp198	1.87
3-Bromopyruvate 7μM R04 exp175	1.9
Monensin 0.3μM R08 exp507	1.95
Sulforaphane 9μM R08 exp525	1.97
Selumetinib 20μM R02 exp81	2.05
2-Deoxy-D-glucose 800μM R05 exp214	2.16
Tubacin 1.6μM R07 exp416	2.16
5-Azacytidine 2μM R07 exp330	2.19
6-Thio-2-deoxyguanosine 2μM R06 exp259	2.28
Benzoate 10000μM R08 exp455	2.29
Docosahexaenoic-acid 50μM R07 exp356	2.29
Latrunculin-B 10μM R07 exp374	2.3
LB-100 2μM R05 exp210	2.31
Pyridostatin 4μM R05 exp240	2.32
Erlotinib 10μM R05 exp216	2.33
Dinaciclib 0.007μM R07 exp355	2.36
QNZ 0.01μM R08 exp439	2.36
ML-792 0.2μM R08 exp505	2.43
TIC10 10μM R08 exp532	2.51
Bortezomib 0.005μM R00 exp6	2.53
Centrinone 0.5μM R07 exp343	2.57
CI-1040 9.5μM R08 exp472	2.57
GSK-J4 1.5μM R08 exp441	2.59
THZ1 0.06μM R08 exp531	2.6
Thapsigargin 0.005μM R07 exp407	2.62
Wortmannin 5μM R00 exp38	2.65
Artemisinin 50μM R08 exp450	2.68
Tozasertib 0.1μM R07 exp414	2.73
Bleomycin 5μM R08 exp459	2.74
LB-100 4.1μM R02 exp72	2.77
MS023 2μM R03 exp134	2.85
Mitomycin-C 0.06μM R08 exp503	3.1
Dynasore 7μM R08 exp436	3.29
Rotenone 20μM R00 exp34	3.29
JQ1 0.8μM R08 exp435	3.33
Aphidicolin 0.4μM R08 exp440	3.39
Dorsomorphin 5μM R07 exp357	3.39
Dynasore 10μM R04 exp180	3.42
AICAR 240μM R05 exp211	3.44
Atovaquone 15μM R08 exp451	3.46
SNS-032 15μM R08 exp443	3.63
Tanespimycin 14μM R08 exp527	3.67
Etoposide 0.3μM R05 exp199	3.88
UM0125461 0.74μM R02 exp84	3.89
Hippuristanol 0.12μM R08 exp488	3.96
Etoposide 1μM R00 exp19	4.02
Hippuristanol 0.12μM R08 exp489 no dilution day6	4.07
Quercetin 20μM R08 exp517	4.09
RO-3307 4.7μM R02 exp80	4.34
CR131-b 0.005μM R08 exp474	4.36
Doxorubicin 0.02μM R08 exp478	4.57
AICAR 240μM R03 exp116	4.71
UM0129480 7μM R02 exp85	4.97
GSK626616 14μM R08 exp485	5.05
Staurosporine 0.02μM R08 exp524	5.12
Olaparib 4μM R08 exp512	5.41
Ethanol 0.01 R05 exp234	5.56
MS023 7μM R03 exp135	6.52
Pimelic-diphenylamide-106 5μM R00 exp28	6.96
5-Fluorouracil 20μM R00 exp2	6.98
Benzoate 20000μM R08 exp456	7.88
Actinomycin-D 0.001μM R00 exp3	7.94

Gene	Correlation
BAK1	0.846
VDAC2	0.802
UBQLN1	0.755
CASP9	0.751
APAF1	0.744
CYCS	0.707
PLAA	0.688
HCCS	0.67
SERF2	0.663
DIABLO	0.646
FAF2	0.592
STAU1	0.585
ATAD1	0.559
MFN1	0.558
DOHH	0.557
HSPD1	0.522
ENY2	0.513
FECH	0.496
HARS	0.492
GABPA	0.485
ROMO1	0.473
METAP2	0.467
MLST8	0.465
RPTOR	0.464
PMAIP1	0.458
TRIAP1	0.457
MTOR	0.457
UAP1	0.45
THG1L	0.448
BAP1	0.448
DDHD2	0.446
GFPT1	0.443
BCL2L11	0.441
ZZZ3	0.438
KCTD5	0.436
SRRD	0.43
WDR24	0.428
ALAS1	0.428
NSD1	0.427
MCL1	0.424
LAMTOR5	0.424
RAD23B	0.421
PDPK1	0.421
KDSR	0.421
MEAF6	0.421
VHL	0.42
NXT1	0.417
CSNK2B	0.413
GMPPB	0.412
NAE1	0.41
UBA3	0.407
WDR59	0.407
FBXO11	0.407
MIOS	0.406
OPA1	0.403
ATP5J	0.402

Global Fraction of Cell Lines Where Essential: 63/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	12/28
bone	3/26
breast	6/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	4/20
lung	3/75
lymphocyte	3/16
ovary	1/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	9/15
prostate	1/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	2/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15886
Expression level (log2 read counts): 5.26

Expression Distribution

positive regulation of mitochondrial fission
regulation of mitochondrial fission
negative regulation of cell aging
GTPase binding
regulation of cell aging
protein autoubiquitination
protein localization to mitochondrion
positive regulation of mitochondrion organization
mitochondrial outer membrane
regulation of mitochondrion organization
ubiquitin-protein transferase activity
protein polyubiquitination
positive regulation of organelle organization
protein ubiquitination
protein localization to organelle
protein modification by small protein conjugation
zinc ion binding
endoplasmic reticulum membrane
negative regulation of developmental process
protein modification by small protein conjugation or removal
endoplasmic reticulum
regulation of anatomical structure morphogenesis
positive regulation of cellular component organization
mitochondrion
regulation of organelle organization
positive regulation of developmental process
cellular protein localization
cellular macromolecule localization
membrane