PAN2

Gene Information

Official Symbol: PAN2
Official Name: poly(A) specific ribonuclease subunit PAN2
Aliases and Previous Symbols: N/A
Entrez ID: 9924
UniProt: Q504Q3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. {ECO:0000255|HAMAP-Rule:MF_03182, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:16284618, ECO:0000269|PubMed:23398456}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
5-Fluorouracil 20μM R00 exp2	-2.57
Brefeldin A 0.02μM R00 exp8	-2.49
Doxorubicin 0.02μM R08 exp478	-2.28
Rotenone 20μM R00 exp34	-2.28
Etoposide 0.3μM R05 exp199	-2.24
PU-H71 1μM R08 exp515	-2.07
Oligomycin-A 20μM R00 exp26	-2.03
Staurosporine 0.02μM R08 exp524	-1.93
THZ531 0.225μM R08 exp444	-1.89
GSK461364A 0.1μM R03 exp126	-1.85
6-Thio-2-deoxyguanosine 2μM R06 exp259	-1.83
Monensin 0.3μM R08 exp507	-1.82
DABN 20μM R00 exp17	-1.81
BI-6727 0.04μM R03 exp98	-1.8
Aphidicolin 0.4μM R08 exp440	-1.72
Latrunculin-B 10μM R07 exp374	-1.72
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.9
LY2090314 0.003μM R08 exp500 no dilution day6	1.99
Docetaxel 0.002μM R01 exp45	2.01
Cerivastatin 0.15μM R05 exp226	2.09
GSK2606414 1μM R05 exp236	2.1
Vinblastine 0.002μM R01 exp60	2.25
FK-506 5μM R07 exp358	2.33

Gene	Correlation
PAN3	0.672
PSMD11	0.564
SMG7	0.564
SUPT6H	0.555
CHD4	0.537
VASN	0.536
CDCA3	0.522
SMG1	0.507
C1QTNF9B	0.507
SLC6A17	0.506
ZFAND5	0.503
PSMC6	0.498
TBC1D3G	0.497
TCEB3C	0.496
SFPQ	0.492
TBC1D3C	0.492
UPF1	0.489
LRR1	0.489
ORC1	0.485
PSMC2	0.484
C14orf93	0.484
PSMD3	0.483
DISP2	0.482
AATF	0.478
CBWD3	0.478
PSMD14	0.475
AQR	0.474
PSMC1	0.471
PSMA6	0.471
IK	0.468
NPIPB5	0.467
MT1E	0.467
POLR1A	0.467
TCEB3CL	0.467
TBC1D3H	0.466
GATA3	0.466
DDTL	0.463
MED14	0.461
PSMB4	0.46
CCNA2	0.46
ATXN1	0.46
RAD21	0.46
TCEB3CL2	0.456
HAP1	0.456
GOLGA6L6	0.455
RPLP1	0.455
GOLGA8O	0.454
POLA1	0.453
COPB1	0.453
SLC38A7	0.453
ORC6	0.452
OGFR	0.452
PSMB2	0.452
ATP13A1	0.449
TBC1D3	0.448
HIVEP3	0.447
MED17	0.447
NUP205	0.446
KCTD17	0.446
DTL	0.445
COL2A1	0.444
RPS19	0.443
PSMD7	0.443
HIST2H3D	0.443
POLR2D	0.443
COPB2	0.442
PAF1	0.441
TP53TG3B	0.44
TP53TG3	0.439
TP53TG3C	0.439
GID4	0.438
WDR43	0.438
FCN2	0.438
TBC1D3I	0.437
TBC1D3K	0.437
TBC1D3F	0.437
CCDC64B	0.437
UQCRH	0.437
TBC1D3L	0.437
TBC1D3E	0.437
EIF4A3	0.436
CDT1	0.435
NOL10	0.434
PSMD1	0.434
ARCN1	0.434
RRP7A	0.434
TSG101	0.433
PSMB1	0.432
SULT1A3	0.432
SULT1A4	0.431
COPA	0.431
SH3BP1	0.431
TICRR	0.431
AAAS	0.43
MBTD1	0.428
NOP16	0.428
KPNB1	0.428
PIGS	0.428
HIST2H3A	0.427
BCL2L1	0.426
RFC1	0.426
HIST2H3C	0.426
ZNF830	0.425
ANKLE2	0.425
PCF11	0.423
POLA2	0.423
PSMC4	0.422
HIST1H2BE	0.422
FBL	0.421
SF3B3	0.421
SSH2	0.421
MED12	0.42
SNRPA1	0.419
SCAF1	0.419
SMG5	0.418
NUP153	0.418
CLPTM1	0.417
S1PR4	0.416
NUPL1	0.416
TWISTNB	0.415
WDR75	0.415
AAMP	0.414
MFSD12	0.414
PWP2	0.414
RPS7	0.412
ARHGEF35	0.412
WDR87	0.412
DNTTIP2	0.412
COPE	0.411
CDC73	0.411
POLR2A	0.41
COPG1	0.409
UBAP2L	0.409
CHCHD3	0.409
CHMP2A	0.408
POLE	0.408
RPS5	0.408
RANBP2	0.408
PBXIP1	0.408
CBWD5	0.407
ZNF106	0.407
LAD1	0.407
RPS9	0.406
MED29	0.406
TERF2	0.405
ADRM1	0.404
TUBA8	0.404
DDX21	0.404
RPL3L	0.404
CCDC94	0.403
RPS2	0.401
PSMC3	0.4
SUPT5H	0.4
CWC22	0.4
KRT78	0.4
ABT1	0.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1571
Expression level (log2 read counts): 6.05

Expression Distribution

RNase T
UCH

PAN complex
positive regulation of cytoplasmic mRNA processing body assembly
regulation of cytoplasmic mRNA processing body assembly
poly(A)-specific ribonuclease activity
nuclear-transcribed mRNA poly(A) tail shortening
3-5-exoribonuclease activity
RNA phosphodiester bond hydrolysis, exonucleolytic
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
positive regulation of organelle assembly
P-body
RNA phosphodiester bond hydrolysis
nucleic acid binding
nuclear-transcribed mRNA catabolic process
mRNA catabolic process
regulation of organelle assembly
RNA catabolic process
positive regulation of protein complex assembly
nucleic acid phosphodiester bond hydrolysis
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
regulation of protein complex assembly
mRNA processing
organic cyclic compound catabolic process
positive regulation of cellular component biogenesis
positive regulation of organelle organization
mRNA metabolic process
RNA processing
cellular macromolecule catabolic process
regulation of cellular component biogenesis
macromolecule catabolic process
positive regulation of cellular component organization
regulation of organelle organization
RNA metabolic process
negative regulation of gene expression
organic substance catabolic process
cellular catabolic process
gene expression