RBM14

Gene Information

Official Symbol: RBM14
Official Name: RNA binding motif protein 14
Aliases and Previous Symbols: N/A
Entrez ID: 10432
UniProt: Q96PK6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Golgicide-A 4μM R03 exp122	-2.83
BI-D1870 2μM R04 exp162	-2.65
Etoposide 0.1μM R05 exp198	-2.37
GSK343 3μM R03 exp124	-2.35
Cisplatin 0.35μM R06 exp273	-2.34
L-BMAA 500 to 750μM on day4 R04 exp185	-2.31
Mubritinib 0.2μM R02 exp65	-2.25
LJH685 5μM R02 exp73	-2.21
Rucaparib 6.5μM R08 exp520	-2.13
SGC2096 2.6μM R03 exp153	-2.13
ML-792 0.2μM R08 exp505	-2.08
Nutlin-3A 1.6μM R06 exp294	-2.05
Hydroxyurea 15μM R06 exp289	-2
Hypoxia 5%O2 R04 exp191	-1.99
UMK57 0.6μM R03 exp107	-1.95
QNZ 0.01μM R08 exp439	-1.93
Bafilomycin-A1 0.009μM R08 exp454	-1.9
BH1 1μM R04 exp169	-1.9
UMK57 1μM R01 exp59	-1.9
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.89
Nocodazole 0.02μM R00 exp23	-1.86
UM0011500 5μM R05 exp245	-1.85
UNC2400 2μM R03 exp156	-1.85
Epigallocatechin gallate 20μM R05 exp230	-1.81
JQ1 0.01μM R03 exp130	-1.8
GSK591 2.6μM R03 exp128	-1.74
Hydroxyurea 100μM R07 exp329	-1.74
Taxol 0.002μM R01 exp54	-1.74
Mubritinib 0.2μM R01 exp48	-1.73
Wiskostatin 3μM R07 exp422	-1.71
IU1-47 25μM R04 exp182	-1.7
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.84
Cytochalasin-B 5μM R07 exp349	1.9
Hippuristanol 0.12μM R08 exp488	2.02
Tozasertib 0.1μM R07 exp414	2.31
Centrinone 0.5μM R07 exp343	2.32
BI-2536 0.02μM R03 exp96	2.33
GSK461364A 0.1μM R03 exp126	2.42
DABN 20μM R00 exp17	2.44
Bortezomib 0.05μM R00 exp7	2.92
DABN racemic mixture R03 exp93	3.84
R-DABN 8μM R03 exp111	3.87
SB743921 0.001μM R05 exp244	4.56
BI-6727 0.04μM R03 exp98	4.98
Nocodazole 0.2μM R02 exp64	5.42
Nocodazole 0.1μM R03 exp94	5.54
HMS-I1 10μM R06 exp256	6.07
Rotenone 2μM R00 exp33	6.36
Vinblastine 0.015μM R05 exp208	6.54
Nocodazole 0.2μM R00 exp24	6.58

Gene	Correlation
MAD2L1	0.816
MAD1L1	0.802
BUB3	0.763
KNTC1	0.746
BUB1B	0.72
ZW10	0.72
TRIP13	0.684
MAD2L1BP	0.655
ZWILCH	0.648
FNTA	0.574
PELO	0.532
MARS	0.506
MED16	0.499
DDX20	0.496
RTCB	0.494
DPAGT1	0.493
TBCA	0.492
GNB1L	0.49
CDC20	0.479
FNTB	0.471
ALG1	0.465
PAM16	0.464
TRMT5	0.463
SRP72	0.459
UAP1	0.456
RNMT	0.456
EPRS	0.448
NSMCE1	0.448
TTI2	0.446
DBR1	0.446
DCTN6	0.446
POLR3B	0.444
POLR3H	0.443
PMM2	0.44
THG1L	0.44
PPP4C	0.433
GTF3C2	0.433
GTF3C4	0.427
AARS	0.426
DHPS	0.425
GFPT1	0.423
OSGEP	0.418
ALG14	0.418
RAD1	0.418
SPCS2	0.418
TTI1	0.417
GEMIN5	0.416
CDIPT	0.415
RABGGTB	0.412
HBS1L	0.412
VMP1	0.41
HARS	0.408
TSEN54	0.407
EIF4E	0.4

Global Fraction of Cell Lines Where Essential: 607/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	24/28
blood	26/28
bone	22/25
breast	27/33
central nervous system	49/56
cervix	4/4
colorectal	15/17
esophagus	9/13
fibroblast	1/1
gastric	13/15
kidney	20/21
liver	15/20
lung	59/75
lymphocyte	12/14
ovary	21/26
pancreas	21/24
peripheral nervous system	12/16
plasma cell	14/15
prostate	1/1
skin	17/24
soft tissue	5/7
thyroid	1/2
upper aerodigestive	19/22
urinary tract	25/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 288
Expression level (log2 read counts): 6.76

Expression Distribution

glucocorticoid receptor signaling pathway
negative regulation of centriole replication
corticosteroid receptor signaling pathway
negative regulation of centrosome duplication
negative regulation of centrosome cycle
intracellular estrogen receptor signaling pathway
regulation of centriole replication
centriole assembly
mediator complex
negative regulation of organelle assembly
regulation of centrosome duplication
histone deacetylation
protein deacetylation
SMAD protein signal transduction
regulation of centrosome cycle
protein deacylation
macromolecule deacylation
nuclear receptor transcription coactivator activity
intracellular steroid hormone receptor signaling pathway
protein binding, bridging
transcription coregulator activity
microtubule organizing center organization
steroid hormone mediated signaling pathway
negative regulation of cytoskeleton organization
ribonucleoprotein complex
intracellular receptor signaling pathway
hormone-mediated signaling pathway
cellular response to steroid hormone stimulus
regulation of microtubule cytoskeleton organization
transmembrane receptor protein serine/threonine kinase signaling pathway
transcription factor complex
DNA replication
regulation of organelle assembly
DNA recombination
regulation of microtubule-based process
activation of innate immune response
negative regulation of cell cycle process
response to steroid hormone
positive regulation of innate immune response
positive regulation of response to biotic stimulus