TMEM261 [The Human Chemical-Genetic Interaction Map Project]

Gene Information

Official Symbol: DMAC1
Official Name: distal membrane arm assembly complex 1
Aliases and Previous Symbols: N/A
Entrez ID: 90871
UniProt: Q96GE9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I. {ECO:0000269|PubMed:27626371}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Senexin-A 25μM R07 exp400	1.72
Hydroxyurea 100μM R07 exp329	1.84
AICAR 240μM R03 exp116	1.86
Monensin 0.3μM R08 exp507	1.88
UM0125461 0.74μM R02 exp84	1.88
Genistein 15μM R07 exp360	2.14
Phenformin 20μM R03 exp143	2.27
Artemisinin 50μM R08 exp450	2.29
Oligomycin-A 2μM R00 exp25	3.78

Gene	Correlation
GRSF1	0.583
NDUFAF3	0.582
NDUFB11	0.574
NDUFAF7	0.548
NDUFC2	0.543
NDUFA2	0.542
MRPS21	0.525
NDUFA1	0.524
NDUFS2	0.512
ACAD9	0.509
ATP5SL	0.507
CARS2	0.506
NDUFB6	0.505
NDUFB5	0.504
NDUFA3	0.5
NDUFA11	0.496
RPUSD3	0.494
ECSIT	0.491
NDUFA8	0.49
NDUFAF4	0.488
SELRC1	0.486
GFM2	0.484
MTG2	0.484
NDUFS7	0.483
MTIF2	0.481
LARS2	0.479
MTO1	0.479
TFB1M	0.475
RPUSD4	0.475
GTPBP10	0.474
C17orf89	0.471
C12orf65	0.469
FOXRED1	0.468
GFM1	0.467
COQ2	0.466
RTN4IP1	0.465
RNASEH1	0.463
YARS2	0.462
NDUFAF1	0.461
HSD17B10	0.461
QRSL1	0.46
NDUFB7	0.46
MALSU1	0.46
MRPS16	0.458
NDUFC1	0.455
NARS2	0.454
TARS2	0.454
PDSS1	0.453
NDUFV2	0.452
MTRF1L	0.45
TEFM	0.449
SSBP1	0.448
CHCHD1	0.447
PARS2	0.447
POLG	0.447
MRPL15	0.446
TIMMDC1	0.445
FTSJ2	0.444
TOMM20	0.443
NDUFA10	0.443
MRPL21	0.442
NDUFB10	0.441
MRPS14	0.441
MCAT	0.44
POLG2	0.438
COA6	0.437
NDUFAF6	0.436
NDUFS5	0.434
MINOS1	0.432
PET112	0.432
NUBPL	0.431
NDUFA5	0.431
MRPS33	0.43
SARS2	0.429
MRPS34	0.428
NDUFA6	0.424
NDUFB9	0.423
NDUFS8	0.423
MRPL45	0.421
PET117	0.418
MRPS25	0.418
NDUFA13	0.418
MRPL53	0.418
MRP63	0.417
FASTKD2	0.416
TIMM21	0.416
MRPS6	0.414
MRPS12	0.413
C10orf2	0.412
TOMM22	0.411
MRPL17	0.411
DAP3	0.41
MRPS5	0.41
MRPS28	0.409
POLRMT	0.409
NSUN4	0.409
NDUFAF5	0.407
HARS2	0.406
COA3	0.406
MARS2	0.406
GTPBP8	0.405
RBFA	0.404
MRPL47	0.404
MRPS26	0.404
HMGXB3	0.402
MTIF3	0.402
MRPL20	0.401

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1531
Expression level (log2 read counts): 4.99

Expression Distribution

Last modified: 2026/01/07 22:37
by 127.0.0.1