RPS28
Gene Information
- Official Symbol: RPS28
- Official Name: ribosomal protein S28
- Aliases and Previous Symbols: N/A
- Entrez ID: 6234
- UniProt: P62857
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S28E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ribosomal S28e |
GO Terms
| cytoplasmic side of rough endoplasmic reticulum membrane |
| small ribosomal subunit |
| ribosomal small subunit assembly |
| polysomal ribosome |
| cytosolic small ribosomal subunit |
| maturation of SSU-rRNA |
| ribosome assembly |
| ribosomal small subunit biogenesis |
| cytoplasmic translation |
| SRP-dependent cotranslational protein targeting to membrane |
| cotranslational protein targeting to membrane |
| protein targeting to ER |
| establishment of protein localization to endoplasmic reticulum |
| viral transcription |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| viral gene expression |
| protein localization to endoplasmic reticulum |
| translational initiation |
| protein targeting to membrane |
| structural constituent of ribosome |
| nuclear-transcribed mRNA catabolic process |
| rRNA processing |
| mRNA catabolic process |
| rRNA metabolic process |
| ribonucleoprotein complex assembly |
| ribonucleoprotein complex subunit organization |
| RNA catabolic process |
| establishment of protein localization to membrane |
| ribosome biogenesis |
| protein targeting |
| nucleobase-containing compound catabolic process |
| translation |
| ncRNA processing |
| peptide biosynthetic process |
| establishment of protein localization to organelle |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| ribonucleoprotein complex biogenesis |
| ncRNA metabolic process |
| protein localization to membrane |
| organic cyclic compound catabolic process |
| amide biosynthetic process |
| peptide metabolic process |
| mRNA metabolic process |
| viral process |
| protein localization to organelle |
| organelle assembly |
| symbiotic process |
| cellular amide metabolic process |
| interspecies interaction between organisms |
| cellular protein-containing complex assembly |
| RNA processing |
| cellular macromolecule catabolic process |
| intracellular protein transport |
| macromolecule catabolic process |
| RNA binding |
| organonitrogen compound biosynthetic process |
| protein transport |
| intracellular transport |
| peptide transport |
| protein-containing complex assembly |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| PSMD11 | 0.545 |
| RPS5 | 0.538 |
| PSMD1 | 0.535 |
| TBC1D3H | 0.53 |
| RPS12 | 0.528 |
| RBBP5 | 0.517 |
| TBC1D3I | 0.512 |
| TBC1D3K | 0.511 |
| TBC1D3E | 0.511 |
| ZFAND5 | 0.51 |
| TBC1D3L | 0.51 |
| TBC1D3G | 0.508 |
| NUP133 | 0.506 |
| CBWD5 | 0.501 |
| PSMC1 | 0.5 |
| VASN | 0.499 |
| PPFIA4 | 0.497 |
| NOP16 | 0.495 |
| PSMB1 | 0.493 |
| RPS9 | 0.491 |
| TBC1D3 | 0.49 |
| TCEB3CL2 | 0.489 |
| AKIRIN2 | 0.488 |
| SCAF1 | 0.487 |
| COPE | 0.486 |
| NUPL1 | 0.483 |
| TBC1D3F | 0.479 |
| TWISTNB | 0.478 |
| TBC1D3C | 0.478 |
| CBWD3 | 0.477 |
| RPS11 | 0.475 |
| RBM39 | 0.474 |
| CDC73 | 0.473 |
| RPS2 | 0.472 |
| PSMB4 | 0.471 |
| RPL30 | 0.47 |
| TOP1MT | 0.47 |
| C1QTNF9B | 0.469 |
| TFIP11 | 0.469 |
| UTP20 | 0.465 |
| AHCTF1 | 0.463 |
| CBWD6 | 0.462 |
| SMG7 | 0.461 |
| CKAP5 | 0.46 |
| RPS14 | 0.457 |
| PSMA6 | 0.455 |
| DDTL | 0.452 |
| ISCU | 0.451 |
| DTL | 0.449 |
| HIVEP3 | 0.449 |
| KCTD17 | 0.448 |
| KIF3C | 0.447 |
| RPS27A | 0.446 |
| ZNF106 | 0.446 |
| NOL10 | 0.443 |
| RNF4 | 0.443 |
| TERF2 | 0.442 |
| RPS16 | 0.442 |
| RPL14 | 0.442 |
| PSMA7 | 0.441 |
| RIOK2 | 0.44 |
| RPS3 | 0.44 |
| ZNF830 | 0.439 |
| BCL2L1 | 0.439 |
| CCNA2 | 0.436 |
| PSMD13 | 0.435 |
| NFATC4 | 0.434 |
| WDR43 | 0.432 |
| SNRPA1 | 0.432 |
| PSMC5 | 0.432 |
| CHD4 | 0.431 |
| PSMA1 | 0.431 |
| RPS7 | 0.43 |
| HAP1 | 0.428 |
| CHAF1A | 0.427 |
| RRN3 | 0.427 |
| POLA1 | 0.426 |
| RPL38 | 0.426 |
| C14orf93 | 0.425 |
| PSMD6 | 0.425 |
| ORC6 | 0.424 |
| TCEB3CL | 0.424 |
| NBPF16 | 0.424 |
| SSH2 | 0.423 |
| MYB | 0.423 |
| TCEB3C | 0.423 |
| OGFR | 0.421 |
| NOP14 | 0.421 |
| RPS19BP1 | 0.421 |
| RPS3A | 0.42 |
| FAM160A1 | 0.419 |
| RPL35 | 0.419 |
| CDC45 | 0.419 |
| SUPT6H | 0.419 |
| PSMD3 | 0.419 |
| PSMC6 | 0.419 |
| GLCCI1 | 0.417 |
| RANBP2 | 0.417 |
| XYLT2 | 0.417 |
| PSMC4 | 0.416 |
| CNPY3 | 0.415 |
| OR10G3 | 0.415 |
| PSMC2 | 0.415 |
| ACSF2 | 0.415 |
| FBXW9 | 0.415 |
| SYT9 | 0.414 |
| NDC1 | 0.414 |
| RFFL | 0.413 |
| DNTTIP2 | 0.412 |
| LRR1 | 0.412 |
| HIST2H2BF | 0.411 |
| S1PR4 | 0.411 |
| DNM2 | 0.411 |
| MT1E | 0.41 |
| SHFM1 | 0.409 |
| RPS6 | 0.408 |
| RPL34 | 0.408 |
| RFC1 | 0.407 |
| PRPF8 | 0.407 |
| POLA2 | 0.406 |
| PWP2 | 0.406 |
| PSMB2 | 0.406 |
| ORC1 | 0.405 |
| TRAIP | 0.405 |
| RAB40AL | 0.405 |
| CTDP1 | 0.404 |
| PAF1 | 0.404 |
| CWC22 | 0.404 |
| TCF3 | 0.403 |
| HIST1H2BE | 0.403 |
| CTR9 | 0.403 |
| ACD | 0.403 |
| GOLGA8O | 0.403 |
| STIL | 0.402 |
| RFXANK | 0.402 |
| CGB2 | 0.401 |
| ARCN1 | 0.401 |
| GOLGA6L3 | 0.401 |
| PLCG2 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 727/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 28/28 |
| bone | 25/26 |
| breast | 32/33 |
| central nervous system | 56/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 20/21 |
| liver | 20/20 |
| lung | 72/75 |
| lymphocyte | 16/16 |
| ovary | 25/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 14/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 21/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 126
- Expression level (log2 read counts): 8.17
Expression Distribution
RPS28 Expression in NALM6 Cells: 8.17
