ATP2B1

Gene Information

Official Symbol: ATP2B1
Official Name: ATPase plasma membrane Ca2+ transporting 1
Aliases and Previous Symbols: N/A
Entrez ID: 490
UniProt: P20020
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
UniProt Summary: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Apcin 25μM plus proTAME 2μM R04 exp177	-3.62
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-3.52
Golgicide-A 4μM R03 exp122	-3.33
Vincristine 0.0005μM R04 exp190	-2.88
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-2.66
Mdivi-1 15μM R05 exp217	-2.59
Hypoxia 5%O2 R04 exp191	-2.58
Parthenolide 2.5μM R05 exp238	-2.52
Geldanamycin 0.01μM R05 exp235	-2.49
GSK461364A 0.005μM R03 exp125	-2.32
S-trityl-L-cysteine 0.5μM R05 exp243	-2.25
Nifuroxazide 5μM R03 exp102	-2.24
Cabazitaxel 0.001μM R05 exp223	-2.21
Cerivastatin 0.15μM R05 exp226	-2.21
ETC-159 50μM R08 exp480	-2.2
FBS-Wisent 0.1 R07 exp426	-2.19
Hippuristanol 0.12μM R08 exp488	-2.17
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.14
Docetaxel 0.002μM R01 exp45	-2.13
Rapamycin 2μM R07 exp306	-2.12
THZ531 0.11 to 0.125μM on day4 R07 exp410	-2.08
Vinblastine 0.002μM R01 exp60	-2.08
HMS-I1 1μM R01 exp46	-2.04
RO-3306 3 to 4μM on day4 R04 exp165	-2.03
Nifuroxazide 1μM R01 exp51	-2.02
Taxol 0.004μM R03 exp103	-2.01
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.96
BI-2536 0.0042μM R03 exp95	-1.96
Celastrol 0.12μM R05 exp225	-1.96
Benzoate 10000μM R08 exp455	-1.89
Rapamycin 0.001μM R08 exp429	-1.87
Colchicine 0.009μM R05 exp215	-1.8
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.8
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-1.8
Sulforaphane 9μM R08 exp525	-1.79
Taxol 0.002μM R01 exp54	-1.78
Caffeine 2600μM R08 exp463	-1.77
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.77
Adefovir 20μM R07 exp332	-1.77
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	-1.75
2-Methoxyestradiol 0.55μM R07 exp310	-1.75
CVT-10216 0.1μM R06 exp278	-1.74
L-BMAA 500 to 750μM on day4 R04 exp185	-1.72
Demecolcine 0.03μM R05 exp228	-1.71
Pomalidomide 20μM R07 exp391	1.72
Lead acetate 990μM R08 exp496	1.74
QNZ 0.01μM R08 exp439	1.74
GSK461364A 0.1μM R03 exp126	1.78
TRAIL 5ng/ml R00 exp35	1.79
Doxycycline 10μM R00 exp18	1.86
5-Fluorouracil 20μM R00 exp2	1.88
Q15 1 to 2μM on day4 R04 exp164	1.93
HMS-I2 10μM R06 exp288	1.97
2-Deoxy-D-glucose 800μM R05 exp214	2
Nocodazole 0.1μM R03 exp94	2
Chlorpromazine 10μM R07 exp344	2.02
CB-5083 0.4μM R08 exp468	2.04
Mitomycin-C 0.06μM R08 exp503	2.06
Atovaquone 15μM R08 exp451	2.07
6-Thio-2-deoxyguanosine 2μM R06 exp259	2.1
LLY-283 2.6μM R06 exp290	2.2
BS-181 20μM R08 exp461	2.25
Clomiphene 4.4μM R02 exp68	2.28
Wortmannin 0.5μM R00 exp37	2.32
Azithromycin 100μM R08 exp452	2.33
Aminopterin 0.005μM R07 exp335	2.6
GSK-J4 1-1.25μM to day4 R07 exp363	2.62
BI-6727 0.04μM R03 exp98	2.75
Bafilomycin-A1 0.009μM R08 exp454	2.81
SNS-032 15μM R08 exp443	2.99
BI-2536 0.02μM R03 exp96	3.23
Rotenone 20μM R00 exp34	3.4
LY2090314 0.003μM R08 exp499	3.59
MLN-4924 0.2μM R00 exp21	3.59
Artemisinin 50μM R08 exp450	3.86
MK2206 4μM R08 exp504	4
LY2090314 0.003μM R08 exp500 no dilution day6	4.17
Calcium Ionophore 0.4μM R07 exp342	4.53
Bleomycin 5μM R08 exp459	4.75
Thapsigargin 0.005μM R07 exp407	8.44

Gene	Correlation
URM1	0.424
DDX39A	0.419
RBBP4	0.408
C16orf80	0.408
KCTD5	0.405
N6AMT1	0.402
DDX1	0.401

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14652
Expression level (log2 read counts): 7.32

Expression Distribution