MCAT

Gene Information

Official Symbol: MCAT
Official Name: malonyl-CoA-acyl carrier protein transacylase
Aliases and Previous Symbols: N/A
Entrez ID: 27349
UniProt: Q8IVS2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Catalyzes the transfer of a malonyl moiety from malonyl- CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondria. {ECO:0000269|PubMed:12882974}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM0125461 0.74μM R02 exp84	1.7
Hydroxyurea 100μM R07 exp329	1.71
GSK626616 14μM R08 exp485	1.88
Chloroquine 32μM R08 exp470	1.98
Resveratrol 16μM R03 exp147	2.77

Gene	Correlation
MTO1	0.57
IBA57	0.57
SFXN4	0.558
GTPBP10	0.556
ACAD9	0.556
GRSF1	0.545
PET117	0.538
NDUFAF3	0.534
C12orf65	0.532
GFM2	0.53
COA6	0.53
FASTKD2	0.529
NDUFAF6	0.529
RPUSD3	0.529
ECSIT	0.526
NDUFB11	0.524
QRSL1	0.52
MIPEP	0.516
HMGXB3	0.516
YBEY	0.515
NSUN4	0.507
PET112	0.504
EARS2	0.503
NDUFA3	0.501
LARS2	0.501
MALSU1	0.5
NDUFAF7	0.496
GLRX5	0.494
RPUSD4	0.492
AARS2	0.489
MRPS5	0.488
MTIF2	0.485
MTG1	0.485
NUBPL	0.485
NDUFA2	0.483
MTRF1L	0.48
COA3	0.48
PARS2	0.479
ERAL1	0.474
MRPS16	0.474
NDUFAF5	0.471
RNASEH1	0.468
GFM1	0.468
MRPL23	0.466
FTSJ2	0.465
NDUFA1	0.464
MRPL22	0.463
MRPS22	0.463
TIMMDC1	0.462
METTL17	0.459
MRPS34	0.459
NDUFB9	0.458
SELRC1	0.457
PDE12	0.457
NARS2	0.457
YARS2	0.454
SSBP1	0.454
NDUFA8	0.454
CHCHD1	0.452
MRPL1	0.452
MRPS21	0.451
AK3	0.45
TSFM	0.449
COQ2	0.448
NDUFS2	0.443
NDUFA10	0.443
FASTKD5	0.443
POLG	0.442
CARS2	0.442
RBFA	0.442
NDUFB6	0.441
MRPL43	0.441
COX11	0.441
ATP5SL	0.44
TMEM261	0.44
NDUFB10	0.44
NDUFV2	0.439
C17orf89	0.439
MRPS26	0.437
FOXRED1	0.437
NDUFB5	0.437
MRPS35	0.432
HSD17B10	0.432
RARS2	0.431
COQ7	0.431
ICT1	0.429
MRPS6	0.428
NFU1	0.428
GTPBP8	0.427
AASDHPPT	0.426
RMND1	0.426
MRPL18	0.426
PRIM1	0.425
PITRM1	0.424
MRPS27	0.424
MRPS18B	0.422
VARS2	0.422
MRPS12	0.421
TARS2	0.42
MTERFD1	0.42
DAP3	0.419
MRPS25	0.419
TFB1M	0.417
MRPL21	0.416
PREPL	0.415
TPK1	0.415
MTG2	0.414
PDSS2	0.414
TOMM20	0.414
MRPS10	0.414
NDUFB7	0.412
DDX28	0.412
MRPL47	0.411
NDUFAF1	0.411
NDUFB2	0.411
WARS2	0.41
MRPL45	0.41
POLG2	0.408
MRPL55	0.408
GOT2	0.408
PTCD3	0.407
MRPL53	0.406
COQ3	0.405
MRPL49	0.405
TIMM8B	0.404
MRPL4	0.403
POLRMT	0.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1682
Expression level (log2 read counts): 3.86

Expression Distribution