MYO1H

Gene Information

Official Symbol: MYO1H
Official Name: myosin IH
Aliases and Previous Symbols: N/A
Entrez ID: 283446
UniProt: Q8N1T3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
JQ1 0.8μM R08 exp435	-2.1
BN82002 4μM R07 exp340	1.7
UMK57 0.6μM R03 exp107	1.72
Demecolcine 0.03μM R05 exp228	1.75
EPZ-5676 30μM R05 exp233	1.75
Thalidomide 20μM R07 exp406	1.8
All-trans-Retinoic-Acid 8μM R07 exp333	1.86
Momordin-Ic 10μM R08 exp506	1.88
Nocodazole 0.02μM R00 exp23	1.89
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.91
CCCP 1μM R00 exp11	1.97
SGC2096 2.6μM R03 exp153	1.98
DABN 2μM R00 exp16	2.13
Nicotinate 1000μM R03 exp140	2.51
Alpha-Amanitin 0.5μM R00 exp5	2.84

Gene	Correlation
ZFAND5	0.564
C14orf93	0.55
CDC73	0.54
VASN	0.529
PSMC2	0.527
ZNF106	0.525
TBC1D3H	0.519
PSMD11	0.515
DTL	0.511
RPS2	0.51
EXOSC9	0.509
COPE	0.508
CHD4	0.508
TCEB3CL2	0.506
PSMA6	0.504
CBWD5	0.504
CBWD3	0.501
SCAF1	0.5
SMG7	0.5
RANBP2	0.499
MT1E	0.497
TFIP11	0.496
PSMC1	0.495
RRP15	0.494
CCNA2	0.494
NBPF10	0.491
PSMC6	0.49
SMG1	0.488
TCEB3C	0.488
PSMD1	0.483
COPG1	0.483
RRN3	0.48
PSMD14	0.479
COPA	0.479
CBWD6	0.477
TBC1D3C	0.477
NPIPB5	0.476
TWISTNB	0.476
TRIM52	0.475
MED17	0.475
TCEB3CL	0.473
RBM39	0.473
PAF1	0.472
TBC1D3	0.471
ORC6	0.47
AQR	0.47
TBC1D3F	0.47
TBC1D3G	0.47
SNRPA1	0.469
TBC1D3I	0.468
TBC1D3E	0.467
TBC1D3K	0.466
TBC1D3L	0.466
RNF113A	0.465
FBXO5	0.465
PLA2G4F	0.465
PWP2	0.463
MYT1L	0.463
PSMD7	0.462
SSH2	0.461
PRPF8	0.46
UPF1	0.459
CDC6	0.459
GOLGA8O	0.458
NOP16	0.454
POLA2	0.454
RFXANK	0.454
SUPT6H	0.453
TICRR	0.452
RAD51	0.452
OR10G3	0.451
CGB2	0.45
AKIRIN2	0.45
CNOT1	0.45
CDC45	0.448
SF3A1	0.446
NOL12	0.445
DDTL	0.444
SYT9	0.444
PSMB4	0.443
RNF4	0.443
LRR1	0.442
KCTD17	0.441
AHCTF1	0.441
PSMC5	0.441
CHMP2A	0.44
COPZ1	0.44
TERF2	0.44
NAPA	0.439
STIL	0.439
ACSF2	0.438
RFPL3	0.438
RBBP5	0.437
PDE4DIP	0.437
RPS3A	0.437
ANKLE2	0.436
ARCN1	0.436
CNPY3	0.435
COPB2	0.435
BCL2L1	0.434
ZNF655	0.433
RPS12	0.433
SLC4A1	0.433
PSMB1	0.432
C1QTNF9B	0.432
DISP2	0.431
CACTIN	0.431
ATP6V1C1	0.431
S1PR4	0.43
KIF3C	0.429
WDR87	0.428
GPRIN2	0.428
BYSL	0.428
NUP85	0.427
RPL14	0.427
CCDC94	0.426
ORC1	0.425
MYH2	0.425
HIST2H2BF	0.424
CHAF1A	0.422
PRSS8	0.422
MMS22L	0.421
PAN3	0.421
UBAP1	0.419
PSMD3	0.419
COL2A1	0.418
CCDC116	0.418
NPIPB8	0.418
SEC13	0.418
CTR9	0.417
ELMOD3	0.416
PCF11	0.416
WDR75	0.416
IK	0.415
NDC1	0.415
COPB1	0.414
RPL30	0.414
NUPL1	0.414
RPS14	0.413
HMGCR	0.413
UTP20	0.411
B3GNT3	0.41
ANKLE1	0.41
MYB	0.41
MDM2	0.41
PSMB2	0.409
RFFL	0.409
CRNKL1	0.408
HAP1	0.407
SLC6A17	0.407
COX8A	0.407
CACNA1A	0.407
FAM25B	0.407
MED14	0.406
WDR46	0.405
RPL35	0.405
NSF	0.405
SH3BP1	0.405
KPNB1	0.405
GOSR2	0.404
EXOSC4	0.404
CMYA5	0.403
PSMC4	0.402
C3orf22	0.401
AAMP	0.401

Global Fraction of Cell Lines Where Essential: 23/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	1/26
breast	3/33
central nervous system	1/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	2/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	2/16
plasma cell	0/15
prostate	1/1
skin	2/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2122
Expression level (log2 read counts): -0.44

Expression Distribution