TAMM41

Gene Information

Official Symbol: TAMM41
Official Name: TAM41 mitochondrial translocator assembly and maintenance homolog
Aliases and Previous Symbols: N/A
Entrez ID: 132001
UniProt: Q96BW9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-6727 0.04μM R03 exp98	1.7
Benzoate 20000μM R08 exp456	1.74
Doxorubicin 0.02μM R08 exp478	1.79
Rotenone 20μM R00 exp34	1.83
SNS-032 15μM R08 exp443	1.87
Dorsomorphin 5μM R07 exp357	1.88
PU-H71 1μM R08 exp515	2.2
42°C R08 exp539	2.35
CFI-400945 25μM R08 exp469	2.36
CoCl2 18μM R07 exp346	2.42
Hippuristanol 0.12μM R08 exp488	2.51
GSK-J4 1.5μM R08 exp441	2.61

Gene	Correlation
TRIAP1	0.661
PMM2	0.653
CRLS1	0.62
HARS	0.594
TAZ	0.592
ROMO1	0.59
ALG1	0.582
UAP1	0.577
THG1L	0.57
RPE	0.566
DNLZ	0.548
OPA1	0.545
DPAGT1	0.541
HCCS	0.536
ALG2	0.534
TIMM13	0.534
ALG13	0.533
GMPPB	0.531
GFPT1	0.528
GTF3C6	0.526
SLC25A26	0.525
GEMIN6	0.512
SUPV3L1	0.511
DOHH	0.507
MRPS14	0.507
PGS1	0.503
TEN1	0.5
SRP14	0.499
EXOC4	0.498
RPIA	0.493
CHCHD4	0.493
ATXN10	0.493
PAM16	0.492
HSPD1	0.49
MRPL23	0.49
PGGT1B	0.489
RNMT	0.485
PGM3	0.485
RTCB	0.485
MRPL21	0.485
DHRSX	0.484
TRNT1	0.483
PPA2	0.483
ATP5A1	0.483
RPP21	0.482
APAF1	0.479
TKT	0.478
EIF3F	0.477
VEZT	0.477
ELAC2	0.475
YARS2	0.474
AARS	0.472
GEMIN8	0.471
DPF2	0.471
GNB1L	0.471
BAK1	0.469
CEP57	0.468
RPTOR	0.468
TPI1	0.468
PPCS	0.466
ALG5	0.464
GTF3C3	0.464
HSD17B10	0.461
SARS2	0.459
TSEN54	0.459
ATP5B	0.458
MRPS18A	0.458
PISD	0.457
PELO	0.456
ZRSR2	0.454
NAE1	0.454
MRPS2	0.453
MRPS6	0.451
DDX55	0.451
ATP5O	0.45
DHPS	0.449
UHRF1	0.448
DAP3	0.447
ATP5J	0.446
TUFM	0.446
CASP9	0.444
MSTO1	0.444
PLAA	0.444
HARS2	0.444
LSM11	0.443
KDSR	0.443
COX16	0.443
ADSL	0.442
CYCS	0.439
RPUSD4	0.438
UBE2G2	0.437
MRPS34	0.437
AASDHPPT	0.436
FASTKD5	0.434
ATP5C1	0.432
CSNK2B	0.43
KIAA0391	0.43
ATIC	0.429
DARS2	0.426
DUSP12	0.426
ALG6	0.426
GEMIN7	0.425
TBCA	0.425
RBFA	0.424
MED16	0.423
SCO2	0.423
BRWD1	0.42
CCT7	0.418
C15orf41	0.417
PPCDC	0.416
BAP1	0.416
PTPMT1	0.415
PDSS1	0.414
TMEM242	0.414
FNTA	0.413
VARS2	0.413
MBTPS2	0.413
MRPS16	0.412
TTC4	0.412
BCS1L	0.411
TARS2	0.411
ENO1	0.411
CDIPT	0.409
ALG8	0.409
NSMCE1	0.405
ORAOV1	0.403
RPN1	0.403
TSEN34	0.402
TTI1	0.402
CEPT1	0.401
MRPS9	0.4
TGS1	0.4
G6PD	0.4

Global Fraction of Cell Lines Where Essential: 610/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	27/28
blood	23/28
bone	22/26
breast	22/33
central nervous system	49/56
cervix	4/4
colorectal	12/17
esophagus	12/13
fibroblast	1/1
gastric	13/16
kidney	19/21
liver	18/20
lung	61/75
lymphocyte	13/16
ovary	24/26
pancreas	22/24
peripheral nervous system	10/16
plasma cell	9/15
prostate	1/1
skin	21/24
soft tissue	6/9
thyroid	1/2
upper aerodigestive	21/22
urinary tract	27/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 1116
Expression level (log2 read counts): 4.2

Expression Distribution