UBE2G2

Gene Information

Official Symbol: UBE2G2
Official Name: ubiquitin conjugating enzyme E2 G2
Aliases and Previous Symbols: N/A
Entrez ID: 7327
UniProt: P60604
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011].
UniProt Summary: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Involved in endoplasmic reticulum- associated degradation (ERAD). {ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:22607976}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Golgicide-A 4μM R03 exp122	-2.48
Cadmium 60μM R08 exp462	-2.07
UM0011500 5μM R05 exp245	-2
TGF-beta1 44ng/ml R08 exp528	-1.76
Ibrutinib 10μM R08 exp442	-1.7
42°C R08 exp539	1.7
Cerivastatin 0.15μM R05 exp226	1.71
Rotenone 0.07μM R08 exp431	1.72
Aminopterin 0.005μM R07 exp335	1.73
ONC212 0.15μM R08 exp513	1.73
Fluvastatin 2.2μM R06 exp282	1.75
Thimerosal 0.85μM R08 exp529	1.75
Hippuristanol 0.12μM R08 exp488	1.78
ML-792 0.2μM R08 exp505	1.78
BI-6727 0.04μM R03 exp98	1.79
LLY-283 2.6μM R06 exp290	1.86
Tanespimycin 14μM R08 exp527	1.87
Etoposide 1μM R00 exp19	1.9
Mitomycin-C 0.06μM R08 exp503	1.94
Hinokiflavone 12μM R08 exp487	1.97
6-Thio-2-deoxyguanosine 2μM R06 exp259	2.05
Mdivi-1 15μM R05 exp217	2.05
SNS-032 15μM R08 exp443	2.05
Etoposide 0.3μM R05 exp199	2.13
Vinblastine 0.2μM R03 exp108	2.13
Phenformin 20μM R05 exp212	2.16
5-Fluorouracil 20μM R00 exp2	2.18
Atovaquone 15μM R08 exp451	2.23
HMS-I1 10μM R06 exp256	2.24
CI-1040 9.5μM R08 exp472	2.26
Actinomycin-D 0.001μM R00 exp3	2.28
Benzoate 20000μM R08 exp456	2.31
Bleomycin 5μM R08 exp459	2.37
Doxorubicin 0.02μM R08 exp478	2.4
UM131593 0.2μM R03 exp106	2.42
Amiloride 100μM R08 exp447	2.48
MS023 7μM R03 exp135	2.54
MLN-4924 0.2μM R00 exp21	4.6

Gene	Correlation
FAF2	0.671
DOHH	0.611
RPTOR	0.601
AUP1	0.599
UBE2J1	0.582
DNAJC3	0.578
ATP5O	0.573
ROMO1	0.563
THG1L	0.557
PMM2	0.556
MANF	0.554
PLAA	0.553
ATP5J	0.552
RNMT	0.55
ALG5	0.544
ATP5A1	0.54
GFPT1	0.537
TRIAP1	0.535
DPAGT1	0.534
ALG1	0.534
UAP1	0.534
CBFB	0.529
ATP5B	0.527
ENY2	0.524
WDR24	0.522
HSPD1	0.517
SRP14	0.514
TMED10	0.513
SEC62	0.511
DOLK	0.508
DERL2	0.504
BAP1	0.504
OPA1	0.503
ELP3	0.502
CTDNEP1	0.501
KDSR	0.5
PPP2R3C	0.499
GTF3C4	0.498
SUV420H1	0.498
ID3	0.497
GMPPB	0.497
ALG6	0.497
UBA5	0.491
MTOR	0.491
CRLS1	0.49
NSD1	0.49
CCDC101	0.488
UFM1	0.486
RTCB	0.482
TRIM28	0.482
DNAJB11	0.481
TAZ	0.48
SEC63	0.478
ATP5I	0.478
TAF4	0.477
GNB1L	0.477
ATP5D	0.476
STT3A	0.476
SSB	0.475
ALG13	0.474
MED16	0.473
APAF1	0.471
UFC1	0.47
VMP1	0.469
XPO6	0.467
EXOC4	0.466
UBE2M	0.464
DHRSX	0.462
CASP9	0.461
TIMM13	0.46
GTF3C6	0.459
PPA2	0.458
BAK1	0.457
VHL	0.456
C1orf27	0.455
LAMTOR4	0.455
IRF2BP2	0.452
TRMT10A	0.451
ADSL	0.451
DERL1	0.45
MLLT1	0.449
TMEM41B	0.448
SMG9	0.447
DAD1	0.446
CEPT1	0.445
RPP21	0.444
CYCS	0.442
UHRF1	0.441
SLC25A26	0.441
URM1	0.44
ATXN10	0.439
TAMM41	0.437
PGGT1B	0.436
ATP5H	0.436
BCS1L	0.432
UBE2K	0.432
MBTPS2	0.432
HCCS	0.431
LSM11	0.43
EIF4E	0.43
UBQLN1	0.429
ATP2A2	0.426
AARS	0.426
NAE1	0.425
DR1	0.425
ALG9	0.425
DIABLO	0.425
LSMD1	0.424
ATP5L	0.422
ATP5C1	0.421
VDAC2	0.419
TTI2	0.419
TIMM22	0.418
UTP23	0.418
ALG2	0.416
TLE4	0.414
RPE	0.413
EED	0.413
TRNT1	0.412
FH	0.412
CMTR1	0.411
RAD23B	0.411
SERF2	0.41
PELO	0.41
SLC35B1	0.407
CHKA	0.406
SUPV3L1	0.406
BTAF1	0.406
DPF2	0.403
GTF2A2	0.403
DENND4A	0.402
GTF3C3	0.402
PDAP1	0.402
CDIPT	0.402
UBA3	0.401
SEC61B	0.4

Global Fraction of Cell Lines Where Essential: 20/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	2/56
cervix	0/4
colorectal	0/17
esophagus	2/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	2/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	5/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 300
Expression level (log2 read counts): 7.98

Expression Distribution