UTP3

Gene Information

Official Symbol: UTP3
Official Name: UTP3 small subunit processome component
Aliases and Previous Symbols: N/A
Entrez ID: 57050
UniProt: Q9NQZ2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity). {ECO:0000250|UniProtKB:Q12136, ECO:0000250|UniProtKB:Q9JI13}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Actinomycin-D 0.01μM R00 exp4	-1.88
Colchicine 0.009μM R05 exp215	1.73
GSK-J5 1.5μM R08 exp484	1.77
TGF-beta1 44ng/ml R08 exp528	1.83
CCCP 0.1μM R00 exp10	1.88
TNF-alpha 44ng/ml R08 exp533	1.93
NN-Dimethylsphingosine 2.5μM R08 exp508	2.14
RS-1 10μM R08 exp519	2.35
Deguelin 0.15μM R05 exp209	2.52

Gene	Correlation
TCEB3C	0.551
GOLGA6L1	0.55
TCEB3CL	0.546
CCNA2	0.546
TBC1D3F	0.542
COPG1	0.539
COX7A2L	0.528
COL2A1	0.524
TCEB3CL2	0.515
TBC1D3H	0.514
SLC4A1	0.508
VPS28	0.506
NSF	0.504
PSMB4	0.503
AAMP	0.501
TBC1D3	0.501
IK	0.497
KRT78	0.497
RPS2	0.494
DISP2	0.492
PSMB2	0.492
RRP7A	0.49
NPIPB5	0.49
CHD4	0.489
DTL	0.488
TSG101	0.488
TBC1D3G	0.486
RANBP2	0.485
AQR	0.481
ACSF2	0.479
PNO1	0.476
POP7	0.474
FAM160A1	0.473
PSMA6	0.473
ATP6V1C1	0.472
NAPA	0.47
DOCK6	0.47
POLR1A	0.47
ANKLE1	0.469
CEP192	0.469
DDT	0.469
EFTUD2	0.468
TBC1D3E	0.467
TBC1D3L	0.467
TBC1D3K	0.466
TBC1D3I	0.466
TWISTNB	0.465
COPZ1	0.463
ATP6V0B	0.46
C14orf93	0.459
CBWD3	0.459
KCTD17	0.459
MT1E	0.459
EBNA1BP2	0.456
PLEKHA4	0.455
COPA	0.455
TYMS	0.454
SLC6A17	0.453
CACTIN	0.453
OR10G3	0.453
BRD2	0.453
TFIP11	0.453
ORC6	0.452
RRP9	0.452
CBWD5	0.451
EXOSC9	0.451
EXOSC6	0.45
DDTL	0.45
ATP1A3	0.449
CBWD6	0.448
AATF	0.448
SUPT5H	0.448
PSMD2	0.447
TP53TG3B	0.446
TP53TG3	0.445
TP53TG3C	0.445
EIF3G	0.445
SNRPA1	0.445
VASN	0.444
RPL35	0.444
HIST2H3A	0.443
XYLT2	0.443
HIST2H3C	0.442
NFATC4	0.441
SYT9	0.441
DHX38	0.44
USP35	0.438
NOL10	0.438
RPL6	0.437
ZNF830	0.436
CTAGE4	0.435
PLA2G4F	0.435
ZNF655	0.434
GOLGA6L3	0.433
PAN3	0.433
SNIP1	0.433
UPF1	0.433
NIPBL	0.433
INTS5	0.432
CDT1	0.432
RBBP5	0.431
AKT1S1	0.431
TP53TG3D	0.431
CHAF1A	0.43
C2orf27B	0.43
PSMD11	0.43
NARFL	0.43
GAR1	0.429
SH3BP1	0.428
CHMP4B	0.428
CCDC116	0.428
POLR2F	0.428
RPS19BP1	0.426
NOP16	0.426
PSMC2	0.426
HIVEP3	0.425
RPL8	0.425
TICRR	0.424
CDH24	0.423
RRP15	0.423
PRPF3	0.423
CLN6	0.423
CDCA5	0.422
UTP20	0.422
EXOSC5	0.421
VPS52	0.421
FAM25B	0.421
TBC1D3C	0.42
POLR2D	0.42
TIMELESS	0.419
RPS12	0.419
RPP40	0.419
GNL2	0.418
POLR2J3	0.418
ATP6AP1	0.418
GID4	0.418
NCL	0.417
RFC1	0.417
MED14	0.417
ORC1	0.416
ART5	0.415
DDX56	0.415
OSBP	0.415
IGFN1	0.414
PSMC1	0.414
SMTN	0.414
CLCN6	0.414
LRR1	0.413
RPS7	0.413
EXOSC3	0.413
POLE	0.413
NELFA	0.412
SAP30BP	0.412
POLA1	0.412
PSMA7	0.412
TPX2	0.412
DIMT1	0.411
NOL7	0.411
PDCD7	0.411
MFSD12	0.41
POLR2I	0.41
ARCN1	0.41
ATP6V0C	0.41
VPS54	0.409
GGA3	0.409
RPS5	0.409
EXD1	0.409
FBXW9	0.407
RAD51	0.407
MMS22L	0.407
MDN1	0.407
AKIRIN2	0.407
TUBA8	0.407
CDC45	0.406
SUPT6H	0.406
SMG1	0.406
RPL30	0.406
TINF2	0.406
COPB1	0.406
NUPL1	0.405
MYB	0.405
GOLGA6B	0.405
PSMB1	0.404
C1QTNF9B	0.404
EGR2	0.404
RFPL3	0.403
ATP6V1A	0.402
ZNF541	0.401
RPS10	0.401
PSMD8	0.401
RPL9	0.4
GOSR2	0.4

Global Fraction of Cell Lines Where Essential: 458/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	17/28
blood	19/28
bone	16/25
breast	11/33
central nervous system	34/56
cervix	4/4
colorectal	12/17
esophagus	9/13
fibroblast	0/1
gastric	8/15
kidney	10/21
liver	11/20
lung	60/75
lymphocyte	10/14
ovary	17/26
pancreas	20/24
peripheral nervous system	11/16
plasma cell	8/15
prostate	0/1
skin	12/24
soft tissue	4/7
thyroid	2/2
upper aerodigestive	12/22
urinary tract	25/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 832
Expression level (log2 read counts): 6.08

Expression Distribution