MRPL33
Gene Information
- Official Symbol: MRPL33
- Official Name: mitochondrial ribosomal protein L33
- Aliases and Previous Symbols: N/A
- Entrez ID: 9553
- UniProt: O75394
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ribosomal L33 |
GO Terms
| mitochondrial large ribosomal subunit |
| mitochondrial translational elongation |
| mitochondrial translational termination |
| translational termination |
| mitochondrial translation |
| translational elongation |
| cellular protein complex disassembly |
| mitochondrial gene expression |
| structural constituent of ribosome |
| protein-containing complex disassembly |
| translation |
| mitochondrial inner membrane |
| cellular component disassembly |
| peptide biosynthetic process |
| amide biosynthetic process |
| peptide metabolic process |
| cellular amide metabolic process |
| mitochondrion |
| organonitrogen compound biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| protein-containing complex subunit organization |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| MRPL47 | 0.587 |
| VARS2 | 0.571 |
| DAP3 | 0.57 |
| YARS2 | 0.568 |
| MRPL21 | 0.561 |
| MRPS14 | 0.561 |
| MRPS18A | 0.56 |
| MRP63 | 0.543 |
| MRPS34 | 0.543 |
| MRPL23 | 0.542 |
| HSD17B10 | 0.53 |
| MRPS6 | 0.529 |
| MRPS26 | 0.526 |
| SUPV3L1 | 0.526 |
| MRPS21 | 0.523 |
| MRPS16 | 0.523 |
| MRPS9 | 0.519 |
| TFAM | 0.517 |
| DARS2 | 0.515 |
| QRSL1 | 0.515 |
| MRPL39 | 0.51 |
| NARS2 | 0.506 |
| TRUB2 | 0.503 |
| KIAA0391 | 0.502 |
| MRPL3 | 0.501 |
| COA5 | 0.501 |
| FARS2 | 0.499 |
| MRPS12 | 0.495 |
| SARS2 | 0.493 |
| COX16 | 0.491 |
| RARS2 | 0.486 |
| MARS2 | 0.484 |
| GFM1 | 0.483 |
| HARS2 | 0.479 |
| MRPS5 | 0.478 |
| MRPL53 | 0.477 |
| UQCRC2 | 0.475 |
| LARS2 | 0.473 |
| MRPL18 | 0.472 |
| MRPS25 | 0.471 |
| RPUSD4 | 0.47 |
| TOMM20 | 0.469 |
| PET112 | 0.468 |
| SLC25A26 | 0.468 |
| TARS2 | 0.468 |
| PTCD3 | 0.466 |
| TFB2M | 0.466 |
| SELRC1 | 0.464 |
| COA3 | 0.462 |
| GTPBP10 | 0.462 |
| MRPL44 | 0.459 |
| MRPS23 | 0.459 |
| MRPL45 | 0.459 |
| MRPL36 | 0.455 |
| NDUFA3 | 0.454 |
| RBFA | 0.453 |
| COX7B | 0.452 |
| PNPT1 | 0.451 |
| MRPS22 | 0.45 |
| MRPL42 | 0.448 |
| MRPS7 | 0.447 |
| EARS2 | 0.446 |
| MTPAP | 0.445 |
| HIGD2A | 0.445 |
| MRPL15 | 0.445 |
| SCO2 | 0.443 |
| MRPS2 | 0.442 |
| AARS2 | 0.439 |
| C10orf2 | 0.439 |
| MRPL41 | 0.438 |
| MRPL12 | 0.438 |
| TEFM | 0.433 |
| TUFM | 0.433 |
| NDUFB9 | 0.431 |
| PARS2 | 0.431 |
| FTSJ2 | 0.43 |
| FASTKD5 | 0.43 |
| ELAC2 | 0.426 |
| MRPL4 | 0.423 |
| BCS1L | 0.422 |
| COX6B1 | 0.42 |
| NDUFAF7 | 0.417 |
| NDUFB3 | 0.415 |
| MTG2 | 0.415 |
| COX6C | 0.414 |
| MRPL28 | 0.413 |
| PET117 | 0.411 |
| LRPPRC | 0.411 |
| NDUFB11 | 0.409 |
| UQCR10 | 0.409 |
| COX15 | 0.407 |
| AIFM1 | 0.406 |
| GATC | 0.405 |
| MRPS24 | 0.405 |
| MTERFD1 | 0.405 |
| MRPL13 | 0.404 |
| NDUFC2 | 0.404 |
| MRPS17 | 0.4 |
| NDUFA1 | 0.4 |
| TFB1M | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 477/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 1/1 |
| bile duct | 16/28 |
| blood | 18/28 |
| bone | 14/26 |
| breast | 24/33 |
| central nervous system | 30/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 11/13 |
| fibroblast | 1/1 |
| gastric | 11/16 |
| kidney | 7/21 |
| liver | 14/20 |
| lung | 58/75 |
| lymphocyte | 11/16 |
| ovary | 15/26 |
| pancreas | 11/24 |
| peripheral nervous system | 10/16 |
| plasma cell | 11/15 |
| prostate | 0/1 |
| skin | 14/24 |
| soft tissue | 3/9 |
| thyroid | 1/2 |
| upper aerodigestive | 18/22 |
| urinary tract | 23/29 |
| uterus | 3/5 |
Essentiality in NALM6
- Essentiality Rank: 230
- Expression level (log2 read counts): 3.83
Expression Distribution
MRPL33 Expression in NALM6 Cells: 3.83
