TSC2
Gene Information
- Official Symbol: TSC2
- Official Name: TSC complex subunit 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 7249
- UniProt: P49815
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| DUF3384 |
| Tuberin |
| Rap GAP |
GO Terms
| TSC1-TSC2 complex |
| negative regulation of mitophagy |
| negative regulation of autophagy of mitochondrion |
| anoikis |
| negative regulation of phosphatidylinositol 3-kinase signaling |
| insulin-like growth factor receptor signaling pathway |
| regulation of mitophagy |
| small GTPase binding |
| negative regulation of macroautophagy |
| negative regulation of insulin receptor signaling pathway |
| negative regulation of cellular response to insulin stimulus |
| protein kinase B signaling |
| Hsp90 protein binding |
| regulation of autophagy of mitochondrion |
| negative regulation of protein kinase B signaling |
| positive chemotaxis |
| phosphatase binding |
| negative regulation of TOR signaling |
| negative regulation of mitochondrion organization |
| regulation of insulin receptor signaling pathway |
| positive regulation of macroautophagy |
| regulation of cellular response to insulin stimulus |
| negative regulation of autophagy |
| neural tube closure |
| tube closure |
| protein import into nucleus |
| primary neural tube formation |
| regulation of TOR signaling |
| neural tube formation |
| import into nucleus |
| regulation of phosphatidylinositol 3-kinase signaling |
| positive regulation of autophagy |
| embryonic epithelial tube formation |
| epithelial tube formation |
| protein import |
| morphogenesis of embryonic epithelium |
| tube formation |
| neural tube development |
| protein localization to nucleus |
| regulation of macroautophagy |
| regulation of mitochondrion organization |
| regulation of endocytosis |
| negative regulation of Wnt signaling pathway |
| regulation of protein kinase B signaling |
| negative regulation of protein kinase activity |
| negative regulation of kinase activity |
| lysosome |
| postsynaptic density |
| negative regulation of cellular catabolic process |
| nucleocytoplasmic transport |
| nuclear transport |
| negative regulation of transferase activity |
| GTPase activator activity |
| epithelial tube morphogenesis |
| negative regulation of catabolic process |
| regulation of autophagy |
| regulation of small GTPase mediated signal transduction |
| regulation of Wnt signaling pathway |
| positive regulation of cellular catabolic process |
| negative regulation of organelle organization |
| negative regulation of protein phosphorylation |
| positive regulation of GTPase activity |
| positive regulation of catabolic process |
| morphogenesis of an epithelium |
| establishment of protein localization to organelle |
| negative regulation of phosphorylation |
| regulation of GTPase activity |
| negative regulation of intracellular signal transduction |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| heart development |
| chemotaxis |
| regulation of vesicle-mediated transport |
| taxis |
| endocytosis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| tissue morphogenesis |
| embryonic morphogenesis |
| negative regulation of protein modification process |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| negative regulation of cell population proliferation |
| import into cell |
| perinuclear region of cytoplasm |
| viral process |
| negative regulation of cellular component organization |
| enzyme linked receptor protein signaling pathway |
| protein localization to organelle |
| positive regulation of hydrolase activity |
| symbiotic process |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| interspecies interaction between organisms |
| regulation of cellular catabolic process |
| tube development |
| circulatory system development |
| regulation of kinase activity |
| protein homodimerization activity |
| anatomical structure formation involved in morphogenesis |
| apoptotic process |
| embryo development |
| regulation of transferase activity |
| Golgi apparatus |
| regulation of catabolic process |
| intracellular protein transport |
| negative regulation of cellular protein metabolic process |
| programmed cell death |
| cell death |
| negative regulation of protein metabolic process |
| epithelium development |
| negative regulation of molecular function |
| regulation of cell cycle |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| regulation of organelle organization |
| locomotion |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| establishment of protein localization |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| intracellular signal transduction |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| nitrogen compound transport |
| regulation of transport |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 18/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 3/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 1/56 |
| cervix | 1/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 1/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 2/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 1/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2132
- Expression level (log2 read counts): 6.39
Expression Distribution
TSC2 Expression in NALM6 Cells: 6.39
