CARS2
Gene Information
- Official Symbol: CARS2
- Official Name: cysteinyl-tRNA synthetase 2, mitochondrial
- Aliases and Previous Symbols: N/A
- Entrez ID: 79587
- UniProt: Q9HA77
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a putative member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of cysteine to tRNA molecules. A splice-site mutation in this gene has been associated with a novel progressive myoclonic epilepsy disease with similar symptoms to MERRF syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2017].
- UniProt Summary: N/A
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 689
- Expression level (log2 read counts): 5.96
CARS2 Expression in NALM6 Cells: 5.96
