COX17

Entrez Summary: N/A
UniProt Summary: Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 175/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	8/28
blood	9/28
bone	9/26
breast	9/33
central nervous system	8/56
cervix	1/4
colorectal	4/17
esophagus	3/13
fibroblast	0/1
gastric	4/16
kidney	3/21
liver	7/20
lung	23/75
lymphocyte	7/16
ovary	3/26
pancreas	1/24
peripheral nervous system	6/16
plasma cell	3/15
prostate	0/1
skin	7/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	4/29
uterus	0/5

Expression Distribution

positive regulation of cytochrome-c oxidase activity
copper chaperone activity
positive regulation of electron transfer activity
regulation of cytochrome-c oxidase activity
cuprous ion binding
regulation of electron transfer activity
copper ion transport
mitochondrial respiratory chain complex IV assembly
regulation of proton transport
respiratory chain complex IV assembly
cytochrome complex assembly
positive regulation of oxidoreductase activity
copper ion binding
mitochondrial intermembrane space
regulation of oxidoreductase activity
mitochondrial respiratory chain complex assembly
positive regulation of ion transmembrane transporter activity
positive regulation of transporter activity
transition metal ion transport
positive regulation of cation transmembrane transport
positive regulation of ion transmembrane transport
regulation of generation of precursor metabolites and energy
positive regulation of transmembrane transport
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
positive regulation of ion transport
regulation of transporter activity
regulation of cation transmembrane transport
generation of precursor metabolites and energy
mitochondrion organization
regulation of ion transmembrane transport
heart development
regulation of transmembrane transport
metal ion transport
regulation of ion transport
brain development
head development
cation transport
cellular protein-containing complex assembly
circulatory system development