RSRC2

Gene Information

Official Symbol: RSRC2
Official Name: arginine and serine rich coiled-coil 2
Aliases and Previous Symbols: N/A
Entrez ID: 65117
UniProt: Q7L4I2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Benzoate 10000μM R08 exp455	-4.69
Sucrose 20000μM R06 exp298	-4.43
Erlotinib 10μM R05 exp216	-3.58
Betulinic acid 10 to 15μM on day4 R05 exp222	-3.55
UM0130462 0.025 to 0.035μM day4 R05 exp247	-3.49
QNZ 0.01μM R05 exp241	-3.41
L-BMAA 500 to 750μM on day4 R04 exp185	-3.37
Momordin-Ic 10μM R08 exp506	-3.1
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-3.05
EPZ-5676 30μM R05 exp233	-3.05
Wortmannin 5μM R00 exp38	-3.02
Lead acetate 2000μM R08 exp497	-2.92
Bafilomycin-A1 0.009μM R08 exp454	-2.86
GSK-J4 1μM R07 exp362	-2.86
Apcin 25μM plus proTAME 2μM R04 exp177	-2.83
Rifampicin 10μM R00 exp32	-2.83
IWR1 50μM R08 exp495	-2.76
Tenofovir 10μM R07 exp405	-2.76
Dimethyloxaloylglycine 100μM R05 exp229	-2.72
Vincristine 0.0005μM R04 exp190	-2.71
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-2.63
2-Methoxyestradiol 0.2μM R01 exp40	-2.6
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-2.6
NMS-873 0.07μM R07 exp380	-2.59
LY2090314 0.003μM R08 exp499	-2.57
GSK-J4 1.5μM R08 exp441	-2.56
Wiskostatin 3μM R07 exp422	-2.55
S-trityl-L-cysteine 0.5μM R05 exp243	-2.52
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.51
2-Methoxyestradiol 0.55μM R07 exp310	-2.47
PT-1 25μM R07 exp392	-2.45
Myriocin 25μM R06 exp293	-2.44
Diepoxybutane 3μM R07 exp354	-2.4
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-2.39
Calcium Ionophore 0.4μM R07 exp342	-2.33
Lead acetate 2000μM R08 exp498 no dilution day6	-2.33
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-2.32
Quercetin 20μM R08 exp517	-2.31
Demecolcine 0.03μM R05 exp228	-2.28
Nicotinamide 2000μM R01 exp50	-2.27
Zebularine 20μM R07 exp423	-2.27
NN-Diethyl-meta-toluamide 100μM R05 exp237	-2.24
Cabazitaxel 0.001μM R05 exp223	-2.23
Losmapimod 1μM R07 exp376	-2.15
QNZ 0.01μM R08 exp439	-2.14
Dexamethasone 0.006μM R07 exp351	-2.13
CoCl2 18μM R07 exp346	-2.12
Fas-L 44ng/ml R08 exp482	-2.11
Temozolomide 200μM R04 exp189	-2.11
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-2.1
5-Azacytidine 2μM R07 exp330	-2.08
ABT-702 5μM R07 exp318	-2.03
Rapamycin 10μM R00 exp30	-2.03
Torin1 0.08μM R02 exp82	-2.03
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-2.02
Doxycycline 10μM R00 exp18	-2.02
CCT251545 0.2μM R06 exp271	-2
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-2
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.99
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-1.94
Etoposide 0.3μM R05 exp199	-1.94
Metformin 40μM R03 exp132	-1.94
Ribavirin 10μM R01 exp52	-1.94
TRAIL 50ng/ml R00 exp36	-1.93
MS023 2μM R03 exp134	-1.92
PFI-2 4μM R05 exp239	-1.92
Nocodazole 0.2μM R02 exp64	-1.91
Trichostatin-A 0.06μM R07 exp415	-1.89
Cycloheximide 0.2μM R00 exp15	-1.88
SGC2043 10μM R03 exp152	-1.87
Rapamycin 2μM plus FK-506 5μM R07 exp308	-1.85
Olaparib 4μM R08 exp512	-1.85
UM0131023 0.05μM R05 exp248	-1.83
Vinorelbine 0.001μM R05 exp249	-1.82
Nutlin-3A 1.6μM R06 exp294	-1.8
DKK1 89ng/ml R08 exp477	-1.79
Ethanol 0.003 R08 exp437	-1.77
Resminostat 0.5μM R07 exp393	-1.77
Trimetrexate 0.03μM R08 exp535	-1.77
Prochlorperazine 5.2μM R02 exp77	-1.76
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-1.73
Asunaprenir 3μM R07 exp336	-1.72
Glyphosate 1000μM R06 exp283	-1.72
Golgicide-A 2μM R03 exp121	-1.72
Atovaquone 15μM R08 exp451	1.78
A-769662 20μM R07 exp331	1.91
Bortezomib 0.005μM R00 exp6	1.92
CHIR-124 0.04μM R06 exp272	1.97
Tozasertib 0.1μM R07 exp414	2.11
Bleomycin 5μM R08 exp459	2.13
Artemisinin 50μM R08 exp450	2.18
Aphidicolin 0.4μM R08 exp440	2.57
Pyrazinamide 100μM R08 exp516	2.72

Global Fraction of Cell Lines Where Essential: 17/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	2/75
lymphocyte	2/16
ovary	1/26
pancreas	1/24
peripheral nervous system	2/16
plasma cell	2/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14138
Expression level (log2 read counts): 7.46

Expression Distribution