STIL

Gene Information

Official Symbol: STIL
Official Name: STIL centriolar assembly protein
Aliases and Previous Symbols: N/A
Entrez ID: 6491
UniProt: Q15468
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CENPJ to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). {ECO:0000269|PubMed:16024801, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:9372240}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CI-1040 9.5μM R08 exp472	-2.2
Aphidicolin 0.4μM R08 exp440	-1.87
Vinblastine 0.015μM R05 exp208	-1.79
GSK-J4 1.5μM R08 exp441	-1.72
FK-506 5μM R07 exp358	1.74
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	1.76
FBS-Wisent 0.1 R07 exp426	1.76
Rifampicin 1μM R00 exp31	1.77
Cycloheximide 0.2μM R00 exp15	1.78
Thalidomide 20μM R07 exp406	1.79
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.81
Cyclosporin-A 0.8μM R07 exp347	1.93
A-769662 20μM R07 exp331	1.98
Lenalidomide 20μM R07 exp375	2.2
Tozasertib 0.1μM R07 exp414	2.26
BRD2 inhibitor II 20μM R07 exp341	2.28
Dexamethasone 0.006μM R07 exp351	2.31
PF-06409577 20μM R07 exp389	2.34
VHL-ligand-1 20μM R07 exp421	2.45

Gene	Correlation
CHD4	0.525
CBWD3	0.524
CBWD6	0.524
SUPT5H	0.52
TBC1D3G	0.519
PSMB4	0.516
CBWD5	0.514
TBC1D3H	0.512
TFIP11	0.509
VASN	0.502
C1QTNF9B	0.499
PLK4	0.497
C14orf93	0.496
TWISTNB	0.496
ATP6V1C1	0.493
TBC1D3F	0.489
PSMA6	0.478
RRP15	0.475
TBC1D3C	0.472
SNRPA1	0.472
VPS54	0.471
POLA1	0.471
NUPL1	0.47
NPIPB5	0.469
COPG1	0.469
CCDC94	0.465
HAP1	0.465
KCTD17	0.464
ORC1	0.464
POLR2F	0.462
OR10G3	0.462
NPIPB8	0.461
MYH2	0.461
MT1E	0.46
COPE	0.46
PSMD3	0.46
POLR2D	0.458
ZNF655	0.457
PSMD2	0.457
SLC4A1	0.453
LAD1	0.452
POLE	0.452
NUP160	0.45
RRN3	0.45
RBBP5	0.449
TBC1D3	0.449
ORC6	0.448
POLD2	0.447
PDE4DIP	0.447
TICRR	0.446
ISCU	0.445
SART1	0.445
OGFR	0.444
NBPF16	0.444
CCNA2	0.444
ZNF830	0.443
CWC22	0.443
TRA2B	0.443
CDC6	0.443
SNRNP200	0.442
MYO1H	0.439
GOLGA6L3	0.438
TONSL	0.438
RFXANK	0.437
CDC45	0.436
CKAP5	0.436
MYB	0.435
PSMB3	0.435
ARCN1	0.434
TCEB3CL2	0.434
RNF4	0.434
CDCA3	0.434
NUP43	0.433
RPS2	0.432
SUPT6H	0.431
MYT1L	0.431
PBXIP1	0.431
ZNF106	0.431
SF3A1	0.429
RAD21	0.428
FBXO5	0.428
DDTL	0.428
GOSR2	0.428
RIOK2	0.427
UPF1	0.424
HIST2H2BF	0.424
POLA2	0.422
OSBP	0.421
AAMP	0.418
ACSF2	0.418
RBM39	0.418
FAM86B2	0.416
EXOSC5	0.415
RPL35	0.415
GOLGA8O	0.415
RPS19BP1	0.414
POLI	0.414
RANGAP1	0.413
HIST1H2BE	0.412
INTS5	0.412
OR11H6	0.412
PSMC2	0.411
COPA	0.411
UQCRH	0.41
RAD51	0.409
TSPY8	0.409
SAP30BP	0.408
IGFN1	0.407
GOLGA6A	0.405
SMC3	0.405
FAM25B	0.405
WDR87	0.405
WDR46	0.404
IK	0.404
COX8A	0.403
RPL38	0.403
TIMELESS	0.402
RPS28	0.402
TCEB3C	0.402
GON4L	0.402
SNRPB	0.401
CHAF1A	0.4

Global Fraction of Cell Lines Where Essential: 104/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	2/28
bone	4/26
breast	3/33
central nervous system	2/56
cervix	0/4
colorectal	2/17
esophagus	2/13
fibroblast	0/1
gastric	2/16
kidney	3/21
liver	2/20
lung	12/75
lymphocyte	2/16
ovary	3/26
pancreas	9/24
peripheral nervous system	3/16
plasma cell	4/15
prostate	1/1
skin	1/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	3/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 1110
Expression level (log2 read counts): 6.26

Expression Distribution

floor plate development
notochord development
protein localization to microtubule organizing center
protein localization to centrosome
regulation of centriole replication
centrosome duplication
protein localization to microtubule cytoskeleton
embryonic axis specification
protein localization to cytoskeleton
regulation of centrosome duplication
regulation of centrosome cycle
heart looping
embryonic pattern specification
determination of heart left/right asymmetry
embryonic heart tube morphogenesis
smoothened signaling pathway
mitotic spindle organization
embryonic heart tube development
centrosome cycle
multicellular organism growth
axis specification
neural tube closure
tube closure
microtubule organizing center organization
primary neural tube formation
microtubule cytoskeleton organization involved in mitosis
neural tube formation
determination of left/right symmetry
determination of bilateral symmetry
embryonic epithelial tube formation
specification of symmetry
epithelial tube formation
centriole
morphogenesis of embryonic epithelium
tube formation
spindle organization
neural tube development
regulation of microtubule cytoskeleton organization
regulation of organelle assembly
regulation of microtubule-based process