TBCA

Gene Information

Official Symbol: TBCA
Official Name: tubulin folding cofactor A
Aliases and Previous Symbols: N/A
Entrez ID: 6902
UniProt: O75347
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Parthenolide 2.5μM R05 exp238	-2.15
Colchicine 0.009μM R05 exp215	-2.11
Isoniazid 100μM R08 exp494	-2.09
Bisphenol S 100μM R08 exp458	-1.93
D-Fructose 10000μM R06 exp279	-1.86
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.82
Methotrexate 0.01μM R08 exp501	-1.81
Cannabidiol 13μM R08 exp465	-1.75
QNZ 0.01μM R08 exp439	-1.75
Nocodazole 0.2μM R00 exp24	1.71
Vitamin-D3 40μM R08 exp536	1.9
Brefeldin A 0.02μM R00 exp8	2.4

Gene	Correlation
DPAGT1	0.571
THG1L	0.563
HARS	0.56
PMM2	0.557
GMPPB	0.544
UAP1	0.536
RTCB	0.532
GFPT1	0.531
ATXN10	0.527
NSMCE1	0.521
TRIAP1	0.514
RNMT	0.507
GEMIN8	0.507
MARS	0.502
FNTA	0.501
UTP23	0.5
GTF3C3	0.494
SRP14	0.494
RBM14	0.492
EPRS	0.49
ALG1	0.487
TTI2	0.485
HSPD1	0.477
ALG13	0.475
ENO1	0.474
DHPS	0.473
DOHH	0.472
ADSL	0.468
HAUS8	0.467
DDX20	0.467
VRK1	0.464
GNB1L	0.463
RPE	0.463
NAE1	0.461
PELO	0.461
TBCD	0.461
DDX55	0.459
VEZT	0.456
ALG14	0.456
DHDDS	0.456
ORAOV1	0.454
GTF3C2	0.45
TSEN34	0.45
GTF3A	0.449
RAD1	0.448
OIP5	0.447
HCCS	0.447
PPP4C	0.445
NARS	0.445
RPTOR	0.444
TIMM13	0.442
TSEN54	0.442
SRP68	0.442
UHRF1	0.441
TPRKB	0.44
ALG2	0.44
TGS1	0.438
MEAF6	0.437
AARS	0.435
SRP72	0.435
POLR3H	0.435
ACTR10	0.433
CSNK2B	0.432
ZRSR2	0.43
DAD1	0.428
ALG5	0.427
GTF3C6	0.427
PPA2	0.426
TAMM41	0.425
POLR3B	0.424
GEMIN6	0.422
TAZ	0.421
OSGEP	0.421
PAM16	0.42
CRLS1	0.42
ORC5	0.42
TXNL4B	0.419
RPP21	0.418
ENY2	0.417
ZNF259	0.416
DCTN6	0.414
EIF4E	0.414
EIF3F	0.414
AASDHPPT	0.413
CRCP	0.412
KNTC1	0.411
TRMT5	0.411
EXOC4	0.411
GEMIN5	0.41
APAF1	0.41
CTC1	0.41
UXT	0.409
MAD2L1	0.406
GTF3C4	0.406
BUB3	0.406
YARS	0.405
GFER	0.405
CCT7	0.404
C14orf80	0.403
EXOC3	0.403
CCDC101	0.402
TRNT1	0.402
PPCS	0.401
PPP2R3C	0.401
PMPCB	0.4
SRP19	0.4
MTOR	0.4

Global Fraction of Cell Lines Where Essential: 244/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	5/28
blood	9/28
bone	11/26
breast	13/33
central nervous system	12/56
cervix	2/4
colorectal	2/17
esophagus	5/13
fibroblast	1/1
gastric	3/16
kidney	4/21
liver	8/20
lung	29/75
lymphocyte	5/16
ovary	6/26
pancreas	12/24
peripheral nervous system	8/16
plasma cell	7/15
prostate	0/1
skin	7/24
soft tissue	5/9
thyroid	1/2
upper aerodigestive	15/22
urinary tract	8/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 1350
Expression level (log2 read counts): 6.23

Expression Distribution