TTI1

Gene Information

Official Symbol: TTI1
Official Name: TELO2 interacting protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 9675
UniProt: O43156
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. {ECO:0000269|PubMed:20427287, ECO:0000269|PubMed:20801936, ECO:0000269|PubMed:20810650}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BH1 1μM R04 exp169	-2.19
LJH685 5μM R02 exp73	-2.18
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-1.81
Celastrol 0.12μM R05 exp225	-1.78
S-trityl-L-cysteine 0.5μM R05 exp243	-1.77
Rapamycin 0.001μM R08 exp429	-1.74
SB203580 25μM R03 exp149	-1.71
Doxorubicin 0.02μM R08 exp478	1.85
DABN racemic mixture R03 exp93	1.96
Atovaquone 15μM R08 exp451	1.98
Actinomycin-D 0.01μM R00 exp4	1.99
BI-2536 0.02μM R03 exp96	2
Hinokiflavone 12μM R08 exp487	2.01
Vinblastine 0.2μM R03 exp108	2.25
MLN-4924 2μM R00 exp22	2.77
THZ1 0.06μM R08 exp531	2.84
SNS-032 15μM R08 exp443	3

Gene	Correlation
GNB1L	0.679
TTI2	0.652
MED16	0.621
TELO2	0.612
RNMT	0.59
TRMT5	0.587
RPTOR	0.563
DPAGT1	0.56
CCDC101	0.56
ALG2	0.558
PMM2	0.558
GMPPB	0.557
AARS	0.555
GTF3C3	0.541
POLR3H	0.541
ALG1	0.535
RTCB	0.529
THG1L	0.527
UHRF1	0.525
MLLT1	0.524
CSNK2B	0.513
PPP4C	0.512
GTF3C2	0.51
EPRS	0.509
GFPT1	0.505
ADSL	0.503
MED23	0.501
CBFB	0.5
GTF3C4	0.494
ATXN10	0.493
GTF3C6	0.491
WDR24	0.49
BAP1	0.488
MAPK14	0.486
DAD1	0.482
PELO	0.481
VMP1	0.481
RPP21	0.479
SRP14	0.478
ELAC2	0.478
MTOR	0.477
NARS	0.474
POLR3B	0.474
DOHH	0.473
SEH1L	0.471
SRP68	0.469
CCT7	0.469
UAP1	0.468
PAX5	0.463
SNAPC5	0.462
GPN2	0.46
YARS	0.456
TMEM41B	0.456
OTUD5	0.455
ALG13	0.454
UXT	0.451
OSGEP	0.451
CBX3	0.45
DDX20	0.449
SLC25A19	0.447
ZRSR2	0.446
DNAJC3	0.445
LSM11	0.444
EIF4E	0.44
TRIAP1	0.44
FNTA	0.439
TLE4	0.439
SRP72	0.437
NAE1	0.437
ATP5J	0.435
CRCP	0.432
POLR3C	0.43
ALG5	0.427
THOC6	0.427
EXOC4	0.427
WDR59	0.426
UBA3	0.426
ZNF259	0.426
NSMCE1	0.426
SLC35B1	0.423
DR1	0.423
SPCS2	0.422
MED4	0.42
TBCB	0.419
WDR82	0.419
TSEN54	0.418
HARS	0.417
RBM14	0.417
DDOST	0.416
VRK1	0.415
ATF7IP	0.415
BUB3	0.415
NUP50	0.414
RFK	0.41
UBR5	0.409
HSPA9	0.408
RAD1	0.407
SMARCD1	0.406
TSEN34	0.406
ALG6	0.405
ENY2	0.405
HSPD1	0.404
EXOC3	0.403
ATP5O	0.403
DHPS	0.402
TAMM41	0.402
TTC4	0.401
CIAO1	0.401
ATP5B	0.4
ID3	0.4
TAF5L	0.4

Global Fraction of Cell Lines Where Essential: 424/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	15/28
blood	19/28
bone	23/26
breast	17/33
central nervous system	35/56
cervix	1/4
colorectal	11/17
esophagus	7/13
fibroblast	1/1
gastric	9/16
kidney	11/21
liver	14/20
lung	45/75
lymphocyte	7/16
ovary	16/26
pancreas	10/24
peripheral nervous system	12/16
plasma cell	10/15
prostate	1/1
skin	14/24
soft tissue	4/9
thyroid	2/2
upper aerodigestive	9/22
urinary tract	15/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 175
Expression level (log2 read counts): 6.01

Expression Distribution