RPS19BP1

Gene Information

Official Symbol: RPS19BP1
Official Name: ribosomal protein S19 binding protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 91582
UniProt: Q86WX3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity. {ECO:0000269|PubMed:17964266}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Gene	Correlation
KCTD17	0.532
C1QTNF9B	0.525
CHAF1A	0.518
TFIP11	0.513
CCNA2	0.513
IK	0.513
TCEB3CL	0.503
TCEB3C	0.501
CDCA3	0.501
TBC1D3G	0.501
HIVEP3	0.5
CRNKL1	0.5
PSMB4	0.498
SSH2	0.498
COPE	0.498
PRPF8	0.497
WDR43	0.496
ORC6	0.494
TBC1D3H	0.493
WDR87	0.492
RPL35	0.49
CBWD5	0.489
NPIPB5	0.488
ATP6V1C1	0.487
TBC1D3	0.484
ORC1	0.483
RAD51	0.483
RPS2	0.483
POLR2J3	0.483
ACSF2	0.482
DNTTIP2	0.481
CBWD3	0.479
CHD4	0.477
TCEB3CL2	0.476
SUPT5H	0.476
TBC1D3F	0.475
NOL12	0.475
PSMD3	0.472
TP53TG3C	0.47
TP53TG3	0.47
TP53TG3B	0.47
NPIPB4	0.469
TBC1D3C	0.469
TICRR	0.467
POLE	0.464
VASN	0.464
IGFN1	0.463
UPF1	0.463
NUPL1	0.462
RPL37A	0.46
RPL34	0.459
HGC6.3	0.458
SNRPA1	0.456
RPS12	0.455
MBTD1	0.453
CLN6	0.452
RRP15	0.452
MADCAM1	0.45
CACTIN	0.448
TSPY8	0.448
PSMC6	0.445
CDC45	0.444
DOCK6	0.443
KRT78	0.443
RRP7A	0.44
RRN3	0.439
NUP153	0.439
TBC1D3E	0.438
TBC1D3I	0.438
TBC1D3L	0.437
TBC1D3K	0.437
MTCH2	0.436
DTL	0.435
CBWD6	0.434
PLK4	0.434
OGFR	0.434
TWISTNB	0.433
SLC4A1	0.433
SAP30BP	0.433
GOLGA6A	0.433
EXD1	0.432
SNRNP70	0.432
SPECC1L	0.432
LOC643669	0.428
SNIP1	0.427
RPS5	0.427
UTP3	0.426
RPL7L1	0.426
FBXW9	0.426
EXOSC5	0.426
VPS28	0.425
RIOK2	0.424
PAF1	0.424
CEP192	0.424
PSMD1	0.423
SUPT6H	0.423
MT1E	0.422
DDTL	0.422
ARCN1	0.422
NIPBL	0.422
POLR2A	0.422
PLEKHA4	0.422
RNPC3	0.421
RPS28	0.421
POLA1	0.421
GOLGA6L1	0.419
NUFIP2	0.419
PSMD6	0.419
COPB1	0.418
ISCU	0.418
ZNF830	0.418
SEC13	0.418
ZNF655	0.417
S1PR4	0.417
ANKLE2	0.416
GOLGA6L3	0.415
INCENP	0.415
NOL10	0.414
CKAP5	0.414
OR10G3	0.414
RPL6	0.414
PCF11	0.414
STIL	0.414
MED14	0.413
AATF	0.413
HIST2H3C	0.412
HIST2H3A	0.411
GON4L	0.411
MYH2	0.411
SHPK	0.411
ANKLE1	0.411
SH3BP1	0.41
RPLP0	0.409
NARFL	0.409
CCDC64B	0.409
RPS9	0.409
PDE4DIP	0.409
CDT1	0.408
PSMB2	0.408
NUP160	0.407
SRGAP2C	0.406
CIAPIN1	0.405
EIF4A3	0.404
MCM7	0.404
NBPF16	0.403
NUP43	0.403
KIF3C	0.403
RPL17	0.402
PDCD7	0.401
PSMA6	0.401
SLC6A17	0.401
ZFAND5	0.4
LAD1	0.4

Global Fraction of Cell Lines Where Essential: 22/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	3/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	4/75
lymphocyte	1/16
ovary	1/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	0/1
skin	2/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1094
Expression level (log2 read counts): 5.51

Expression Distribution

Screen	Score
QNZ 0.01μM R05 exp241	-1.8
Methotrexate 0.01μM R08 exp501	1.71
B02 10μM R08 exp453	2.01

enzyme binding
nucleolus
RNA binding