AARS
Gene Information
- Official Symbol: AARS1
- Official Name: alanyl-tRNA synthetase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 16
- UniProt: P49588
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:28493438). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:28493438). {ECO:0000255|HAMAP- Rule:MF_03133, ECO:0000269|PubMed:27622773, ECO:0000269|PubMed:27911835, ECO:0000269|PubMed:28493438}.
Pfam Domains GO Terms
Pfam Domains
| tRNA-synt 2c |
| DHHA1 |
| tRNA SAD |
GO Terms
| regulation of cytoplasmic translational fidelity |
| Ser-tRNA(Ala) hydrolase activity |
| alanyl-tRNA aminoacylation |
| alanine-tRNA ligase activity |
| regulation of cytoplasmic translational elongation |
| aminoacyl-tRNA editing activity |
| aminoacyl-tRNA metabolism involved in translational fidelity |
| amino acid binding |
| translation regulator activity |
| regulation of translational elongation |
| regulation of translational fidelity |
| cerebellar Purkinje cell layer development |
| regulation of cytoplasmic translation |
| tRNA aminoacylation for protein translation |
| cerebellar cortex development |
| tRNA aminoacylation |
| amino acid activation |
| neuromuscular process controlling balance |
| tRNA binding |
| tRNA modification |
| cerebellum development |
| neuromuscular process |
| metencephalon development |
| tRNA processing |
| negative regulation of neuron apoptotic process |
| hindbrain development |
| RNA modification |
| tRNA metabolic process |
| negative regulation of neuron death |
| regulation of neuron apoptotic process |
| cellular amino acid metabolic process |
| regulation of neuron death |
| regulation of translation |
| translation |
| ncRNA processing |
| regulation of cellular amide metabolic process |
| peptide biosynthetic process |
| ncRNA metabolic process |
| posttranscriptional regulation of gene expression |
| amide biosynthetic process |
| peptide metabolic process |
| brain development |
| head development |
| cellular amide metabolic process |
| zinc ion binding |
| RNA processing |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| carboxylic acid metabolic process |
| central nervous system development |
| negative regulation of cell death |
| oxoacid metabolic process |
| organic acid metabolic process |
| mitochondrion |
| nervous system process |
| organonitrogen compound biosynthetic process |
| ATP binding |
| regulation of apoptotic process |
| regulation of programmed cell death |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| regulation of cell death |
| cellular macromolecule biosynthetic process |
| small molecule metabolic process |
| macromolecule biosynthetic process |
| system process |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Etoposide 1μM R00 exp19 | 1.81 |
| THZ1 0.06μM R08 exp531 | 1.84 |
| Rotenone 2μM R00 exp33 | 1.86 |
| Actinomycin-D 0.001μM R00 exp3 | 1.93 |
| Rotenone 20μM R00 exp34 | 2.07 |
| MLN-4924 2μM R00 exp22 | 2.1 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| CCDC101 | 0.62 |
| TTI2 | 0.617 |
| RNMT | 0.597 |
| GMPPB | 0.59 |
| EIF4E | 0.582 |
| PELO | 0.58 |
| HARS | 0.569 |
| RPTOR | 0.566 |
| RTCB | 0.566 |
| PMM2 | 0.565 |
| CCT7 | 0.561 |
| MED16 | 0.56 |
| TRIAP1 | 0.559 |
| MED23 | 0.555 |
| TTI1 | 0.555 |
| GTF3C2 | 0.548 |
| NARS | 0.544 |
| DPAGT1 | 0.539 |
| MAPK14 | 0.537 |
| GNB1L | 0.536 |
| HSPD1 | 0.534 |
| TELO2 | 0.534 |
| GTF3C3 | 0.532 |
| GFPT1 | 0.531 |
| OTUD5 | 0.53 |
| MEAF6 | 0.529 |
| ALG5 | 0.529 |
| ALG1 | 0.528 |
| VRK1 | 0.528 |
| NAE1 | 0.524 |
| ALG2 | 0.523 |
| EPRS | 0.514 |
| TAZ | 0.512 |
| THG1L | 0.512 |
| MTOR | 0.511 |
| TLE4 | 0.509 |
| SLC35B1 | 0.508 |
| PAM16 | 0.505 |
| CBFB | 0.504 |
| UAP1 | 0.504 |
| PGGT1B | 0.501 |
| SPCS3 | 0.5 |
| ALG13 | 0.498 |
| MLLT1 | 0.498 |
| YARS | 0.497 |
| WDR24 | 0.496 |
| CSNK2B | 0.495 |
| TRMT5 | 0.492 |
| SRP14 | 0.491 |
| MARS | 0.49 |
| SRP68 | 0.488 |
| DDOST | 0.487 |
| SEH1L | 0.486 |
| RPN1 | 0.486 |
| SRP72 | 0.485 |
| GTF3C6 | 0.483 |
| EXOC4 | 0.48 |
| ALG14 | 0.48 |
| DOHH | 0.48 |
| PPP2R3C | 0.474 |
| TAMM41 | 0.472 |
| PPP4C | 0.472 |
| TBP | 0.468 |
| BAP1 | 0.466 |
| TSEN34 | 0.464 |
| OSGEP | 0.464 |
| PIK3R4 | 0.462 |
| DPF2 | 0.462 |
| ATXN10 | 0.462 |
| DHX29 | 0.46 |
| VMP1 | 0.46 |
| MED4 | 0.459 |
| POLR3H | 0.458 |
| ATP5J | 0.457 |
| TSEN54 | 0.457 |
| NUP50 | 0.457 |
| FNTA | 0.456 |
| ID3 | 0.454 |
| NSMCE2 | 0.451 |
| DAD1 | 0.451 |
| GTF3C4 | 0.45 |
| DHPS | 0.449 |
| UBE2L3 | 0.448 |
| RPE | 0.447 |
| TSEN2 | 0.444 |
| POLR3B | 0.444 |
| THOC6 | 0.444 |
| DHDDS | 0.443 |
| UXT | 0.442 |
| ENY2 | 0.44 |
| SMARCD1 | 0.44 |
| GFER | 0.439 |
| CBX3 | 0.439 |
| DDX20 | 0.438 |
| ZNF259 | 0.435 |
| HAUS8 | 0.435 |
| TBCA | 0.435 |
| ADSL | 0.435 |
| RPP21 | 0.434 |
| LAMTOR5 | 0.432 |
| PISD | 0.432 |
| PAX5 | 0.431 |
| TMEM41B | 0.429 |
| DCTN6 | 0.428 |
| TRNT1 | 0.427 |
| SPCS2 | 0.427 |
| SEC61G | 0.427 |
| MAX | 0.426 |
| RBM14 | 0.426 |
| UBE2G2 | 0.426 |
| NAA20 | 0.423 |
| NSMCE1 | 0.422 |
| LSMD1 | 0.421 |
| ATP5B | 0.42 |
| EEF1E1 | 0.42 |
| ENO1 | 0.419 |
| NXT1 | 0.418 |
| ATF7IP | 0.418 |
| UHRF1 | 0.418 |
| TRIM28 | 0.415 |
| RAD1 | 0.412 |
| CARS | 0.412 |
| VEZT | 0.411 |
| DNAJB11 | 0.411 |
| RNF126 | 0.41 |
| TPRKB | 0.41 |
| ALG6 | 0.41 |
| GEMIN5 | 0.407 |
| TXNRD1 | 0.406 |
| CRLS1 | 0.405 |
| UBA3 | 0.404 |
| TADA1 | 0.403 |
| CTDNEP1 | 0.403 |
| DNAJC3 | 0.402 |
| ARIH1 | 0.401 |
| TMED10 | 0.401 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 738/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 28/28 |
| bone | 26/26 |
| breast | 33/33 |
| central nervous system | 56/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 21/21 |
| liver | 20/20 |
| lung | 75/75 |
| lymphocyte | 16/16 |
| ovary | 26/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 542
- Expression level (log2 read counts): 7.62
Expression Distribution
AARS Expression in NALM6 Cells: 7.62
