GPR107

Gene Information

Official Symbol: GPR107
Official Name: G protein-coupled receptor 107
Aliases and Previous Symbols: N/A
Entrez ID: 57720
UniProt: Q5VW38
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins. {ECO:0000269|PubMed:25031321}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R08 exp434	-5.73
Bafilomycin-A1 0.009μM R08 exp454	-4.98
Vemurafenib 6.6μM R02 exp89	-4.88
Wortmannin 5μM R00 exp38	-4.6
Clomiphene 4.4μM R02 exp68	-4.51
Caffeine 2600μM R08 exp463	-4.18
BH1 1μM R04 exp169	-4.04
ETC-159 50μM R08 exp480	-3.92
Ibrutinib 10μM R08 exp442	-3.86
Tubacin 1.6μM R07 exp416	-3.8
CFI-400945 25μM R08 exp469	-3.67
BS-181 20μM R08 exp461	-3.51
WYE-354 6μM R02 exp90	-3.4
Celastrol 0.12μM R05 exp225	-3.22
CAY10603 0.55μM R08 exp467	-3.2
Cannabidiol 20μM R08 exp466	-3.16
Cryptotanshinone 12μM R05 exp227	-3.15
Thioridazine 5μM R08 exp530	-3.15
Trametinib 10μM R02 exp83	-3.13
Ribavirin 10 to 15μM on day4 R04 exp160	-3.05
Lapatinib 5μM R01 exp47	-3.04
JQ1 0.8μM R08 exp435	-3.01
Betulinic acid 10 to 15μM on day4 R05 exp222	-2.98
Monensin 0.3μM R08 exp507	-2.97
Rapamycin 10μM R00 exp30	-2.97
SNS-032 15μM R08 exp443	-2.93
Selumetinib 20μM R02 exp81	-2.9
BVD-523 15μM R02 exp67	-2.73
SB203580 25μM R03 exp149	-2.56
Nicotine 3000μM R08 exp510	-2.55
SB202190 10μM R03 exp148	-2.54
MK2206 4μM R08 exp504	-2.42
Myriocin 25μM R06 exp293	-2.42
Cannabidiol 13μM R08 exp465	-2.37
Prochlorperazine 5.2μM R02 exp77	-2.34
UM0125461 0.74μM R02 exp84	-2.34
Fluvastatin 2.2μM R06 exp282	-2.33
Wortmannin 0.5μM R00 exp37	-2.33
CB-839 10μM R05 exp224	-2.26
CCT251545 20μM R07 exp326	-2.26
Bisphenol A 100μM R06 exp269	-2.23
Wiskostatin 3μM R07 exp422	-2.17
Cincreasin 100μM R08 exp473	-2.15
Ribavirin 10μM R01 exp52	-2.12
S-DABN 8μM R03 exp112	-2.1
Chlorpromazine 10μM R07 exp344	-2.06
Momordin-Ic 10μM R08 exp506	-2.03
LLY-283 2.6μM R06 exp290	-2.02
EPZ-5676 30μM R05 exp233	-2.01
Bisphenol F 50μM R08 exp457	-2
GSK343 3μM R03 exp124	-2
NFN1 1μM R03 exp100	-1.99
Oligomycin-A 20μM R00 exp26	-1.99
FTY720 3μM R08 exp483	-1.95
Rapamycin 1μM R00 exp29	-1.95
Q15 2.7μM R02 exp79	-1.92
Q15 1 to 2μM on day4 R04 exp164	-1.91
LJH685 50μM R08 exp433	-1.87
PU-H71 1μM R08 exp515	-1.85
proTAME 5μM R04 exp187	-1.82
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-1.81
Milciclib 2μM R08 exp502	1.97

Gene	Correlation
JTB	0.653
ARL1	0.627
COG7	0.555
ZFAT	0.553
COG5	0.549
TBC1D23	0.518
UNC50	0.507
TSSC1	0.495
CHKA	0.491
SCYL1	0.486
MBTPS1	0.484
VKORC1L1	0.474
SPTLC1	0.473
RAB1B	0.462
RGP1	0.458
FLVCR1	0.457
WDR7	0.455
PCYT1A	0.449
COMMD3	0.446
ATP6V0A2	0.443
COG6	0.436
SLC39A9	0.43
ARPC4	0.429
PI4KB	0.426
USP32	0.422
TBC1D22B	0.421
CCDC132	0.414
APBA3	0.414
KIAA1432	0.413
SCAP	0.408

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16811
Expression level (log2 read counts): 6.37

Expression Distribution

Lung 7-TM R
GpcrRhopsn4

clathrin heavy chain binding
clathrin-dependent endocytosis
clathrin-coated vesicle
receptor-mediated endocytosis
early endosome
endocytosis
import into cell
Golgi apparatus
vesicle-mediated transport