NOL10

Gene Information

Official Symbol: NOL10
Official Name: nucleolar protein 10
Aliases and Previous Symbols: N/A
Entrez ID: 79954
UniProt: Q9BSC4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM0011500 10μM R05 exp246	1.71
Ribavirin 10μM R01 exp52	1.72
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.77
BI-6727 0.001μM R01 exp42	1.88
Wortmannin 0.5μM R00 exp37	1.96
Cycloheximide 0.02μM R00 exp14	3.1

Gene	Correlation
RPL6	0.557
RPS12	0.556
CHD4	0.549
VASN	0.524
TIMELESS	0.523
RPL35	0.517
SUPT6H	0.517
TCEB3C	0.512
GOLGA6L1	0.51
RPS7	0.51
TBC1D3	0.507
PRIM1	0.502
SLC6A17	0.502
RPS3A	0.501
DTL	0.496
TICRR	0.495
TBC1D3F	0.495
TCEB3CL2	0.489
TERF1	0.488
TWISTNB	0.485
RBM39	0.484
PSMD3	0.477
PSMB4	0.475
TBC1D3H	0.475
AAMP	0.475
CTAGE4	0.474
KCTD17	0.474
PSMC6	0.472
BYSL	0.469
TCEB3CL	0.469
ARCN1	0.469
ORC6	0.469
OGFR	0.468
RRP15	0.468
PAN3	0.467
WDR43	0.465
NUPL1	0.465
NOP16	0.463
ZNF830	0.462
TBC1D3I	0.462
TBC1D3E	0.462
TBC1D3L	0.462
TBC1D3K	0.461
C14orf93	0.461
TBC1D3G	0.461
DNTTIP2	0.46
ORC1	0.46
PSMA6	0.457
POLA1	0.457
PPAN	0.457
COPB1	0.456
PSMD11	0.454
MFSD12	0.454
PSMB1	0.453
NBPF10	0.452
SF3A3	0.452
EBNA1BP2	0.452
AKT1S1	0.451
RPS9	0.45
CCNA2	0.45
CEP192	0.449
KIAA0947	0.449
POLR2D	0.448
NOP14	0.447
RPL34	0.446
CLN6	0.445
PCF11	0.445
IK	0.445
TP53TG3B	0.444
RPS2	0.443
TP53TG3	0.443
RPS28	0.443
PBXIP1	0.443
BRIX1	0.442
SH3BP1	0.442
TP53TG3C	0.442
CBWD3	0.44
PSMA7	0.44
NAPA	0.44
POLR1A	0.439
PWP2	0.439
UTP3	0.438
RNPC3	0.437
DDX56	0.437
NOL12	0.437
COPE	0.436
GOLGA8O	0.436
COPG1	0.436
IGFN1	0.435
TFIP11	0.435
PAN2	0.434
XYLT2	0.432
PSMD14	0.432
RIOK2	0.432
CDC6	0.431
AQR	0.43
OSBP	0.428
PSMB2	0.428
SUPT5H	0.427
TBC1D3C	0.427
ATP6V1C1	0.427
SULT2B1	0.426
ATP6AP2	0.424
POLE	0.424
SYT9	0.424
POLR2H	0.424
PSMD7	0.423
OR10G3	0.423
TERF2	0.422
TGM5	0.422
POLA2	0.422
KRT78	0.421
SNIP1	0.42
ANKLE2	0.42
C3orf17	0.42
CBWD6	0.419
TYMS	0.419
RPS3	0.419
MYB	0.418
UTP20	0.418
SAP30BP	0.418
CDH24	0.417
KRT2	0.417
CDCA3	0.417
SRFBP1	0.417
RPS5	0.417
HIST1H2BE	0.417
CBWD5	0.417
MED14	0.417
COPB2	0.416
EXOSC4	0.416
RFFL	0.416
EXOSC9	0.415
PSMD2	0.415
CHAF1A	0.415
C1QTNF9B	0.414
RPS19BP1	0.414
CCDC116	0.414
RAD51	0.413
WDR87	0.413
SSH2	0.412
CDC73	0.412
KIF3C	0.411
RPL14	0.409
CCDC64B	0.409
EXOSC3	0.408
VPS28	0.408
NPIPB8	0.408
AATF	0.407
GOSR2	0.407
CGB2	0.407
ATP6AP1	0.407
ZFAND5	0.407
DIMT1	0.406
TSPY8	0.406
EXD1	0.405
FBXW9	0.405
SMG7	0.405
ZNF106	0.405
RPL7	0.405
MKI67IP	0.404
RPS11	0.403
RPL31	0.403
DDTL	0.402
TSPY2	0.402
HIST1H4B	0.402
FAM160A1	0.402
RNF113A	0.401
NPIPB5	0.4
NXF1	0.4

Global Fraction of Cell Lines Where Essential: 728/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	26/28
bone	26/26
breast	30/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	15/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 723
Expression level (log2 read counts): 5.7

Expression Distribution

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
small-subunit processome
maturation of SSU-rRNA
ribosomal small subunit biogenesis
rRNA processing
rRNA metabolic process
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
nucleolus
RNA processing
RNA binding
RNA metabolic process
gene expression