ORAOV1
Gene Information
- Official Symbol: LTO1
- Official Name: LTO1 maturation factor of ABCE1
- Aliases and Previous Symbols: N/A
- Entrez ID: 220064
- UniProt: Q8WV07
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Yae1 N |
GO Terms
| protein maturation by [4Fe-4S] cluster transfer |
| protein maturation by iron-sulfur cluster transfer |
| ribosomal large subunit biogenesis |
| telomere maintenance |
| telomere organization |
| translational initiation |
| protein maturation |
| ribosome biogenesis |
| anatomical structure homeostasis |
| translation |
| peptide biosynthetic process |
| cellular component |
| ribonucleoprotein complex biogenesis |
| amide biosynthetic process |
| peptide metabolic process |
| DNA metabolic process |
| molecular function |
| cellular amide metabolic process |
| chromosome organization |
| organonitrogen compound biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| homeostatic process |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| THG1L | 0.655 |
| RNMT | 0.625 |
| GFPT1 | 0.607 |
| DPAGT1 | 0.603 |
| PMM2 | 0.581 |
| UAP1 | 0.578 |
| ATXN10 | 0.576 |
| GMPPB | 0.568 |
| ALG1 | 0.557 |
| ALG2 | 0.554 |
| DR1 | 0.551 |
| RPTOR | 0.531 |
| MED16 | 0.529 |
| TGS1 | 0.529 |
| DAD1 | 0.527 |
| TTC4 | 0.527 |
| PELO | 0.526 |
| DOHH | 0.526 |
| TRIAP1 | 0.513 |
| RTCB | 0.506 |
| HSPD1 | 0.496 |
| ALG13 | 0.493 |
| TRNT1 | 0.491 |
| HAUS8 | 0.488 |
| UTP23 | 0.482 |
| PAM16 | 0.48 |
| TSEN54 | 0.48 |
| SRP68 | 0.478 |
| EXOC4 | 0.478 |
| TSEN34 | 0.477 |
| UXT | 0.473 |
| ALG5 | 0.469 |
| MTOR | 0.467 |
| ROMO1 | 0.466 |
| TRMT10A | 0.466 |
| ADSL | 0.464 |
| MIS18A | 0.458 |
| DDOST | 0.458 |
| SRP72 | 0.457 |
| GTF3C3 | 0.457 |
| OIP5 | 0.457 |
| CRCP | 0.456 |
| EIF4E | 0.455 |
| RPN1 | 0.455 |
| TBCA | 0.454 |
| GNB1L | 0.452 |
| THOC6 | 0.45 |
| VEZT | 0.45 |
| UBA3 | 0.444 |
| CASP9 | 0.444 |
| WDR59 | 0.443 |
| YARS | 0.443 |
| MED4 | 0.442 |
| TMEM41B | 0.441 |
| HARS | 0.44 |
| BUB3 | 0.44 |
| HCCS | 0.44 |
| SRP14 | 0.439 |
| PPCS | 0.438 |
| NAE1 | 0.436 |
| MARS | 0.436 |
| TTI2 | 0.436 |
| TAZ | 0.435 |
| POLR3H | 0.434 |
| CCDC101 | 0.434 |
| ENY2 | 0.434 |
| PDAP1 | 0.434 |
| WDR24 | 0.431 |
| GTF3C4 | 0.429 |
| LAMTOR5 | 0.428 |
| CSNK2B | 0.425 |
| PPP2R3C | 0.424 |
| RPP21 | 0.424 |
| DPF2 | 0.423 |
| WDR82 | 0.421 |
| FNTA | 0.42 |
| DDX20 | 0.417 |
| DHPS | 0.417 |
| BAP1 | 0.416 |
| ELP3 | 0.415 |
| RPIA | 0.414 |
| LSMD1 | 0.413 |
| NARS | 0.413 |
| MEAF6 | 0.413 |
| CHORDC1 | 0.409 |
| MBTPS2 | 0.408 |
| ZNF259 | 0.408 |
| EIF3F | 0.407 |
| ATIC | 0.407 |
| RPE | 0.405 |
| PPA2 | 0.404 |
| PLAA | 0.404 |
| ZBTB11 | 0.403 |
| ELAC2 | 0.403 |
| TAMM41 | 0.403 |
| ZRSR2 | 0.403 |
| ENO1 | 0.402 |
| SRPRB | 0.402 |
| TBP | 0.4 |
| GTF2H3 | 0.4 |
| TIMM22 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 726/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 28/28 |
| bone | 26/26 |
| breast | 33/33 |
| central nervous system | 56/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 12/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 21/21 |
| liver | 17/20 |
| lung | 74/75 |
| lymphocyte | 16/16 |
| ovary | 26/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 14/15 |
| prostate | 1/1 |
| skin | 23/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 20/22 |
| urinary tract | 27/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 273
- Expression level (log2 read counts): 5.01
Expression Distribution
ORAOV1 Expression in NALM6 Cells: 5.01
