RPL6
Gene Information
- Official Symbol: RPL6
- Official Name: ribosomal protein L6
- Aliases and Previous Symbols: N/A
- Entrez ID: 6128
- UniProt: Q02878
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of the large ribosomal subunit. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000305|PubMed:12962325}.
Pfam Domains GO Terms
Pfam Domains
| Ribosomal L6e |
| Ribosomal L6e N |
GO Terms
| ribosomal large subunit assembly |
| polysomal ribosome |
| rough endoplasmic reticulum |
| ribosome assembly |
| cytosolic large ribosomal subunit |
| cytoplasmic ribonucleoprotein granule |
| ribosomal large subunit biogenesis |
| cytoplasmic translation |
| SRP-dependent cotranslational protein targeting to membrane |
| cotranslational protein targeting to membrane |
| protein targeting to ER |
| establishment of protein localization to endoplasmic reticulum |
| viral transcription |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| viral gene expression |
| protein localization to endoplasmic reticulum |
| translational initiation |
| protein targeting to membrane |
| structural constituent of ribosome |
| nuclear-transcribed mRNA catabolic process |
| mRNA catabolic process |
| ribonucleoprotein complex assembly |
| ribonucleoprotein complex subunit organization |
| RNA catabolic process |
| postsynaptic density |
| establishment of protein localization to membrane |
| ribosome biogenesis |
| cadherin binding |
| protein targeting |
| nucleobase-containing compound catabolic process |
| translation |
| peptide biosynthetic process |
| focal adhesion |
| establishment of protein localization to organelle |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| ribonucleoprotein complex biogenesis |
| protein localization to membrane |
| organic cyclic compound catabolic process |
| amide biosynthetic process |
| peptide metabolic process |
| mRNA metabolic process |
| viral process |
| protein localization to organelle |
| organelle assembly |
| symbiotic process |
| cellular amide metabolic process |
| interspecies interaction between organisms |
| cellular protein-containing complex assembly |
| cellular macromolecule catabolic process |
| intracellular protein transport |
| macromolecule catabolic process |
| RNA binding |
| organonitrogen compound biosynthetic process |
| DNA binding |
| protein transport |
| intracellular transport |
| peptide transport |
| protein-containing complex assembly |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| proTAME 5μM R04 exp187 | 1.79 |
| NFN1 0.1μM R01 exp49 | 1.97 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| NOL10 | 0.557 |
| PSMB4 | 0.557 |
| RPL35 | 0.537 |
| TCEB3CL2 | 0.525 |
| TCEB3C | 0.522 |
| NOL12 | 0.521 |
| CHD4 | 0.519 |
| GOLGA6L1 | 0.516 |
| CLN6 | 0.513 |
| TBC1D3F | 0.508 |
| RPS12 | 0.508 |
| GOLGA8O | 0.506 |
| POLR2J3 | 0.504 |
| RPS7 | 0.499 |
| TCEB3CL | 0.499 |
| NPIPB8 | 0.499 |
| TIMELESS | 0.497 |
| TBC1D3H | 0.497 |
| TBC1D3G | 0.494 |
| MKI67IP | 0.491 |
| TBC1D3 | 0.489 |
| RPL17 | 0.488 |
| TBC1D3C | 0.487 |
| NARFL | 0.486 |
| PSMA6 | 0.483 |
| TBC1D3E | 0.479 |
| TBC1D3I | 0.479 |
| TBC1D3K | 0.478 |
| TBC1D3L | 0.478 |
| POLA2 | 0.478 |
| C1QTNF9B | 0.476 |
| RPS2 | 0.476 |
| RBBP5 | 0.476 |
| TICRR | 0.473 |
| HAP1 | 0.473 |
| DTL | 0.473 |
| KRT78 | 0.473 |
| ORC1 | 0.47 |
| IGFN1 | 0.469 |
| RPL30 | 0.469 |
| PPM1D | 0.468 |
| RAD51 | 0.463 |
| RPL13 | 0.463 |
| PSMA7 | 0.461 |
| SLC6A17 | 0.459 |
| CDC73 | 0.457 |
| CACTIN | 0.456 |
| BRD2 | 0.453 |
| TSPY2 | 0.453 |
| SSH2 | 0.45 |
| DDX47 | 0.449 |
| KIAA0947 | 0.448 |
| RPL9 | 0.448 |
| TP53TG3D | 0.448 |
| AQR | 0.447 |
| TSPY1 | 0.446 |
| C14orf93 | 0.446 |
| CTAGE4 | 0.444 |
| PSMB3 | 0.444 |
| DHX38 | 0.443 |
| AATF | 0.443 |
| FAM160A1 | 0.443 |
| CDCA3 | 0.443 |
| NUPL1 | 0.443 |
| CCDC116 | 0.443 |
| MFSD12 | 0.44 |
| EXOSC9 | 0.44 |
| RPL34 | 0.439 |
| RPL31 | 0.438 |
| KCTD17 | 0.438 |
| PPAN | 0.438 |
| TP53TG3B | 0.438 |
| DDTL | 0.437 |
| TUBA8 | 0.437 |
| TP53TG3 | 0.437 |
| BRIX1 | 0.437 |
| UTP3 | 0.437 |
| WDR87 | 0.436 |
| TP53TG3C | 0.436 |
| ZNF574 | 0.436 |
| RPL14 | 0.435 |
| CDH24 | 0.435 |
| VASN | 0.435 |
| POLA1 | 0.434 |
| EBNA1BP2 | 0.434 |
| CBWD5 | 0.434 |
| GOLGA6L3 | 0.432 |
| AKT1S1 | 0.432 |
| RPS3A | 0.431 |
| S1PR4 | 0.431 |
| CEP192 | 0.431 |
| PSMC1 | 0.43 |
| SH3BP1 | 0.43 |
| RRP1 | 0.429 |
| POLR1A | 0.429 |
| ZFAND5 | 0.429 |
| RRP15 | 0.429 |
| NSF | 0.428 |
| RPL15 | 0.427 |
| VPS28 | 0.426 |
| COPA | 0.426 |
| ART5 | 0.426 |
| PCF11 | 0.425 |
| CBWD3 | 0.425 |
| DIDO1 | 0.425 |
| EXOSC8 | 0.425 |
| RPS5 | 0.424 |
| PLA2G4F | 0.424 |
| EXOSC5 | 0.424 |
| PAF1 | 0.424 |
| RPL7L1 | 0.423 |
| HINFP | 0.423 |
| PSMB1 | 0.423 |
| ORC6 | 0.422 |
| AKIRIN2 | 0.422 |
| CDC6 | 0.421 |
| COPB1 | 0.421 |
| HEATR1 | 0.421 |
| PSMD2 | 0.421 |
| RPS19 | 0.42 |
| RRP7A | 0.42 |
| RPL27 | 0.419 |
| LAD1 | 0.419 |
| GOLGA6L4 | 0.419 |
| SUPT6H | 0.419 |
| AGAP5 | 0.419 |
| CTR9 | 0.419 |
| ZNF583 | 0.418 |
| BYSL | 0.416 |
| PSMC6 | 0.416 |
| TSPY8 | 0.416 |
| PSMC2 | 0.415 |
| RPS19BP1 | 0.414 |
| SART1 | 0.414 |
| NGDN | 0.413 |
| AAMP | 0.413 |
| LRR1 | 0.412 |
| SLC38A7 | 0.412 |
| TTC31 | 0.412 |
| NCL | 0.411 |
| TWISTNB | 0.41 |
| MYO18A | 0.41 |
| GGA3 | 0.41 |
| MCOLN1 | 0.41 |
| SF3A3 | 0.41 |
| IK | 0.409 |
| PWP2 | 0.408 |
| COL2A1 | 0.408 |
| SYT9 | 0.408 |
| FAM25B | 0.407 |
| RPS6 | 0.407 |
| NUP98 | 0.407 |
| SUPT5H | 0.407 |
| SNRNP70 | 0.406 |
| TYMS | 0.406 |
| GOSR2 | 0.406 |
| PAN3 | 0.405 |
| RPS20 | 0.405 |
| NCAPG | 0.405 |
| EXOSC4 | 0.404 |
| DHFR | 0.404 |
| EXOSC6 | 0.404 |
| ZNF830 | 0.404 |
| SLC4A1 | 0.404 |
| DNTTIP2 | 0.404 |
| MMS22L | 0.403 |
| ZNF106 | 0.403 |
| RPS9 | 0.402 |
| FBXW9 | 0.402 |
| CACNA1A | 0.402 |
| MCM7 | 0.402 |
| ANKLE1 | 0.401 |
| NBPF16 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 427/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 1/1 |
| bile duct | 23/28 |
| blood | 14/28 |
| bone | 14/26 |
| breast | 18/33 |
| central nervous system | 32/56 |
| cervix | 1/4 |
| colorectal | 9/17 |
| esophagus | 4/13 |
| fibroblast | 1/1 |
| gastric | 10/16 |
| kidney | 17/21 |
| liver | 11/20 |
| lung | 49/75 |
| lymphocyte | 8/16 |
| ovary | 16/26 |
| pancreas | 11/24 |
| peripheral nervous system | 6/16 |
| plasma cell | 10/15 |
| prostate | 0/1 |
| skin | 20/24 |
| soft tissue | 5/9 |
| thyroid | 2/2 |
| upper aerodigestive | 11/22 |
| urinary tract | 8/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 333
- Expression level (log2 read counts): 9.38
Expression Distribution
RPL6 Expression in NALM6 Cells: 9.38
