SSBP1
Gene Information
- Official Symbol: SSBP1
- Official Name: single stranded DNA binding protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6742
- UniProt: Q04837
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA.
Pfam Domains GO Terms
Pfam Domains
| SSB |
GO Terms
| positive regulation of helicase activity |
| mitochondrial DNA replication |
| regulation of helicase activity |
| mitochondrion morphogenesis |
| mitochondrial nucleoid |
| positive regulation of ATPase activity |
| regulation of ATPase activity |
| single-stranded DNA binding |
| DNA-dependent DNA replication |
| DNA replication |
| mitochondrial matrix |
| chromatin binding |
| mitochondrion organization |
| cell part morphogenesis |
| positive regulation of hydrolase activity |
| cellular component morphogenesis |
| mitochondrion |
| regulation of hydrolase activity |
| RNA binding |
| positive regulation of catalytic activity |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| LARS2 | 0.559 |
| GRSF1 | 0.559 |
| POLG2 | 0.556 |
| FTSJ2 | 0.548 |
| NARS2 | 0.545 |
| CHCHD1 | 0.537 |
| NDUFB11 | 0.532 |
| NDUFA1 | 0.531 |
| ACAD9 | 0.528 |
| FASTKD2 | 0.524 |
| NUBPL | 0.518 |
| DAP3 | 0.517 |
| MRPL45 | 0.512 |
| NDUFS2 | 0.506 |
| HMGXB3 | 0.503 |
| MTG2 | 0.503 |
| NDUFA11 | 0.499 |
| NDUFB10 | 0.498 |
| CARS2 | 0.497 |
| PET117 | 0.497 |
| SFXN4 | 0.493 |
| MRPL21 | 0.493 |
| GTPBP10 | 0.492 |
| MALSU1 | 0.492 |
| MTIF2 | 0.492 |
| NDUFC2 | 0.489 |
| NDUFAF5 | 0.486 |
| C12orf65 | 0.486 |
| RPUSD3 | 0.485 |
| QRSL1 | 0.484 |
| MTRF1L | 0.483 |
| NDUFB9 | 0.482 |
| NDUFB6 | 0.482 |
| GFM2 | 0.479 |
| NDUFAF6 | 0.478 |
| MTG1 | 0.477 |
| MTO1 | 0.477 |
| NDUFB7 | 0.475 |
| TFB1M | 0.474 |
| NDUFAF3 | 0.473 |
| MRPL22 | 0.473 |
| PARS2 | 0.472 |
| PET112 | 0.469 |
| NDUFAF7 | 0.464 |
| MRPS21 | 0.464 |
| GFM1 | 0.463 |
| MRPL3 | 0.461 |
| NDUFA3 | 0.46 |
| NDUFS1 | 0.46 |
| MRPS7 | 0.459 |
| WBSCR16 | 0.459 |
| HSD17B10 | 0.459 |
| PDE12 | 0.457 |
| RPUSD4 | 0.457 |
| MRP63 | 0.456 |
| DDX28 | 0.456 |
| MCAT | 0.454 |
| MRPL4 | 0.454 |
| PTCD3 | 0.454 |
| TARS2 | 0.452 |
| AARS2 | 0.452 |
| ATP5SL | 0.451 |
| FASTKD5 | 0.449 |
| TOMM6 | 0.448 |
| TMEM261 | 0.448 |
| NDUFC1 | 0.447 |
| MRPL20 | 0.446 |
| PREPL | 0.446 |
| METTL17 | 0.445 |
| MRPL49 | 0.444 |
| NDUFA2 | 0.444 |
| MRPS16 | 0.443 |
| TIMMDC1 | 0.44 |
| POLRMT | 0.44 |
| MRPL1 | 0.439 |
| C1QBP | 0.439 |
| POLG | 0.439 |
| COA3 | 0.437 |
| MRPS18B | 0.437 |
| COX11 | 0.434 |
| MIPEP | 0.434 |
| MRPL47 | 0.433 |
| MRPS9 | 0.432 |
| MRPS6 | 0.432 |
| MRPS5 | 0.431 |
| SELRC1 | 0.43 |
| MTERFD2 | 0.426 |
| MRPL23 | 0.425 |
| NSUN4 | 0.424 |
| MRPL44 | 0.423 |
| MRPL12 | 0.423 |
| MRPS25 | 0.422 |
| RARS2 | 0.421 |
| MRPL53 | 0.421 |
| NDUFB3 | 0.419 |
| GTPBP8 | 0.418 |
| YARS2 | 0.417 |
| MTERFD1 | 0.417 |
| NDUFS5 | 0.416 |
| NDUFA8 | 0.416 |
| ECSIT | 0.412 |
| CLPP | 0.411 |
| EARS2 | 0.41 |
| AIFM1 | 0.409 |
| DARS2 | 0.409 |
| COX16 | 0.407 |
| ERAL1 | 0.405 |
| NDUFV1 | 0.404 |
| COQ2 | 0.404 |
| RNASEH1 | 0.403 |
| MRPS22 | 0.403 |
| MRPS26 | 0.402 |
| RNMTL1 | 0.402 |
| MRPS23 | 0.402 |
| MRPL39 | 0.402 |
| MRPL43 | 0.402 |
| RTN4IP1 | 0.401 |
| RBFA | 0.401 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 19/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 2/28 |
| blood | 1/28 |
| bone | 1/26 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 1/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 2/21 |
| liver | 1/20 |
| lung | 0/75 |
| lymphocyte | 1/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1719
- Expression level (log2 read counts): 6.83
Expression Distribution
SSBP1 Expression in NALM6 Cells: 6.83
