XAB2

Gene Information

Official Symbol: XAB2
Official Name: XPA binding protein 2
Aliases and Previous Symbols: N/A
Entrez ID: 56949
UniProt: Q9HCS7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pimelic-diphenylamide-106 5μM R00 exp28	-3.2
DABN 20μM R00 exp17	-2.74
JQ1 0.8μM R08 exp435	-2.7
Nocodazole 0.2μM R00 exp24	-2.55
Palbociclib 1μM R07 exp382	-2.47
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-2.29
Taxol 0.004μM R03 exp103	-2.28
Brefeldin A 0.02μM R00 exp8	-2.27
Bortezomib 0.05μM R00 exp7	-2.01
iCRT14 30μM R08 exp492	-1.96
Nocodazole 0.1μM R03 exp94	-1.94
TGF-beta1 44ng/ml R08 exp528	-1.87
Actinomycin-D 0.01μM R00 exp4	-1.79
ML-792 0.2μM R08 exp505	-1.77
Monensin 0.3μM R08 exp507	-1.77
CR131-b 0.005μM R08 exp474	-1.76
Lead acetate 990μM R08 exp496	-1.76
Pterostilbene 16μM R02 exp78	-1.76
Dorsomorphin 5μM R07 exp357	-1.74
Phenformin 20μM R03 exp143	-1.73
Campthothecin 0.001μM R06 exp270	1.72
A-395 10μM R05 exp218	1.73
UMK57 0.6μM R03 exp107	1.74
Geldanamycin 0.01μM R05 exp235	1.76
L-BMAA 500 to 750μM on day4 R04 exp185	1.76
S-trityl-L-cysteine 0.5μM R05 exp243	1.76
Dimethyloxaloylglycine 100μM R05 exp229	1.82
39°C R06 exp303	1.84
Apcin 50 to 100μM on day4 R04 exp176	1.85
Q15 1 to 2μM on day4 R04 exp164	1.85
Latrunculin-B 10μM R07 exp374	1.92
MKC9989 10μM R03 exp133	1.93
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.97
CVT-10216 0.1μM R06 exp278	2
NN-Diethyl-meta-toluamide 500μM R08 exp438	2
A-395N 10μM R05 exp219	2.34
ABT-702 5μM plus CoCl2 18μM R07 exp320	2.38
GSK2606414 1μM R05 exp236	2.43
UM0130462 0.025 to 0.035μM day4 R05 exp247	2.69
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	2.77
Vincristine 0.0005μM R04 exp190	3.08
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	3.13
Fas-L 44ng/ml R08 exp482	3.18

Gene	Correlation
PRIM1	0.575
UPF1	0.529
EXOSC5	0.494
PSMB4	0.491
RPS12	0.488
POLA1	0.488
POLR2J3	0.484
CBWD3	0.482
C1QTNF9B	0.479
DDTL	0.471
PSMB2	0.469
SUPT5H	0.464
TCEB3CL2	0.463
KRT2	0.462
COPG1	0.46
FAM25B	0.459
CBWD5	0.456
TBC1D3H	0.455
PSMC5	0.45
CBWD6	0.447
COPA	0.446
TBC1D3F	0.446
TFIP11	0.444
PSMA6	0.442
PSMD3	0.44
TCEB3C	0.439
ATP6V0B	0.438
RRP7A	0.438
KRT78	0.438
PSMA7	0.437
ORC1	0.437
EXOSC9	0.435
AQR	0.431
CDC45	0.43
SMG1	0.43
ZNF830	0.428
NUPL1	0.428
TYMS	0.428
TCEB3CL	0.426
CHAF1A	0.426
RANBP2	0.425
TBC1D3C	0.425
HIVEP3	0.425
ALDH1B1	0.425
INTS5	0.424
PSMC2	0.423
RBBP5	0.422
ATP6V1A	0.422
TBC1D3G	0.421
CDH24	0.42
TRAIP	0.42
CCNA2	0.419
RPL35	0.418
SF3A1	0.417
ANKLE1	0.417
WDR75	0.417
SNRPA1	0.415
TONSL	0.415
ISCU	0.414
C14orf93	0.412
POLE	0.411
SYT9	0.411
TBC1D3	0.411
PLK1	0.411
CCDC116	0.41
COPE	0.41
SH3BP1	0.409
NSF	0.409
CHD4	0.407
PSMD14	0.406
NUP160	0.406
DNTTIP2	0.405
AATF	0.405
OGFR	0.404
BYSL	0.404
TBC1D3I	0.404
TSPY2	0.404
TPX2	0.404
TBC1D3L	0.404
TBC1D3K	0.404
CACTIN	0.404
TBC1D3E	0.404
RPS5	0.403
GOLGA8O	0.403
TRAPPC11	0.402
COX7A2L	0.402
PRSS8	0.4
MED17	0.4
LRR1	0.4
TP53TG3B	0.4
TP53TG3	0.4

Global Fraction of Cell Lines Where Essential: 739/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 444
Expression level (log2 read counts): 6.04

Expression Distribution

generation of catalytic spliceosome for first transesterification step
spliceosomal conformational changes to generate catalytic conformation
post-mRNA release spliceosomal complex
Prp19 complex
U2-type catalytic step 2 spliceosome
transcription-coupled nucleotide-excision repair
catalytic step 2 spliceosome
blastocyst development
nucleotide-excision repair
cerebral cortex development
pallium development
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
telencephalon development
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
in utero embryonic development
forebrain development
RNA splicing
ribonucleoprotein complex biogenesis
mRNA processing
DNA repair
chordate embryonic development
transcription, DNA-templated
nucleic acid-templated transcription
embryo development ending in birth or egg hatching
RNA biosynthetic process
mRNA metabolic process
brain development
DNA metabolic process
cellular response to DNA damage stimulus
head development
cellular protein-containing complex assembly
RNA processing
embryo development
central nervous system development
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process