NPRL2

Gene Information

Official Symbol: NPRL2
Official Name: NPR2 like, GATOR1 complex subunit
Aliases and Previous Symbols: N/A
Entrez ID: 10641
UniProt: Q8WTW4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. {ECO:0000269|PubMed:23723238}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LY2090314 0.003μM R08 exp500 no dilution day6	-4.14
3-Bromopyruvate 7μM R04 exp175	-3.99
Cryptotanshinone 12μM R05 exp227	-3.8
Docosahexaenoic-acid 50μM R07 exp356	-3.63
LY2090314 0.003μM R08 exp499	-3.53
Vincristine 0.0005μM R04 exp190	-3.37
CB-5083 0.4μM R08 exp468	-3.13
Artemisinin 50μM R08 exp450	-3.12
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-2.99
Tubacin 1.6μM R07 exp416	-2.97
Hydroxyurea 100μM R07 exp329	-2.95
Sulforaphane 9μM R08 exp525	-2.92
Demecolcine 0.03μM R05 exp228	-2.91
TRAIL 50ng/ml R00 exp36	-2.83
Sulforaphane 9μM R08 exp526 no dilution day6	-2.81
Genistein 15μM R07 exp360	-2.76
Quercetin 20μM R08 exp517	-2.74
Diepoxybutane 3μM R07 exp354	-2.73
LLY-283 2.6μM R06 exp290	-2.72
PU-H71 1μM R08 exp515	-2.72
AICAR 240μM R05 exp211	-2.64
Nutlin-3A 1.6μM R06 exp294	-2.61
proTAME 5μM R04 exp187	-2.6
UM0125461 0.74μM R02 exp84	-2.53
Aminopterin 0.005μM R07 exp335	-2.49
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-2.47
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-2.45
Etoposide 0.1μM R05 exp198	-2.45
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-2.42
GSK461364A 0.005μM R03 exp125	-2.37
Bortezomib 0.005μM R00 exp6	-2.35
Pterostilbene 16μM R02 exp78	-2.35
Colchicine 0.009μM R05 exp215	-2.29
Golgicide-A 4μM R03 exp122	-2.28
UM0130462 0.025 to 0.035μM day4 R05 exp247	-2.25
PFI-2 4μM R05 exp239	-2.21
Apcin 50 to 100μM on day4 R04 exp176	-2.2
Dynasore 10μM R04 exp180	-2.2
S-trityl-L-cysteine 0.5μM R05 exp243	-2.16
Parthenolide 2.5μM R05 exp238	-2.14
BI-D1870 2μM R04 exp162	-2.13
Deferoxamine 11μM R07 exp350	-2.13
Rucaparib 6.5μM R08 exp520	-2.13
Thimerosal 0.85μM R08 exp529	-2.13
TRAIL 5ng/ml R00 exp35	-2.12
BI-D1870 3.15μM R02 exp66	-2.1
ML-792 0.2μM R08 exp505	-2.1
RO-3306 3 to 4μM on day4 R04 exp165	-2.07
HMS-I2 10μM R06 exp288	-2.06
Rifampicin 30μM R08 exp430	-2.06
Epigallocatechin gallate 20μM R05 exp230	-2.03
GSK591 2.6μM R03 exp128	-2.03
Apcin 25μM plus proTAME 2μM R04 exp177	-2.02
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-2.02
Epothilone-B 0.0015μM R05 exp231	-2
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.96
Citral 50μM R06 exp274	-1.95
MSC2530818 10μM R07 exp379	-1.95
UM0011500 5μM R05 exp245	-1.94
Vinblastine 0.002μM R01 exp60	-1.92
Cabazitaxel 0.001μM R05 exp223	-1.91
FK-506 5μM R07 exp358	-1.9
LLY-284 2.6μM R06 exp291	-1.89
BN82002 4μM R07 exp340	-1.88
BML-284 0.09μM R08 exp460	-1.87
UM0011500 10μM R05 exp246	-1.87
I-BRD9 4μM R07 exp365	-1.85
SNS-032 15μM R08 exp443	-1.85
Dynasore 7μM R08 exp436	-1.84
Cannabidiol 20μM R08 exp466	-1.82
UMK57 0.6μM R03 exp107	-1.82
BS-181 20μM R08 exp461	-1.8
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-1.79
IU1-C 25μM R04 exp183	-1.78
Pifithrin-alpha 20μM R07 exp390	-1.76
Docetaxel 0.002μM R01 exp45	-1.75
TNF-alpha 44ng/ml R08 exp533	-1.75
Radicicol 0.16μM R05 exp242	-1.74
CR131-b 0.005μM R08 exp474	-1.72
BVD-523 15μM R02 exp67	-1.71
ONC212 0.15μM R08 exp513	-1.7
Lapatinib 5μM R01 exp47	1.73
Bisphenol A 100μM R06 exp269	1.75
Vemurafenib 6.6μM R08 exp434	1.77
SGC0946 7μM R03 exp151	1.96
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.99
Thioridazine 5μM R08 exp530	1.99
Hydroxychloroquine 30μM R08 exp490	2.06
39°C R06 exp303	2.11
Palbociclib 1μM R07 exp382	2.15
EPZ-5676 30μM R05 exp233	2.4
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	2.41
Hippuristanol 0.12μM R08 exp488	2.48
Oligomycin-A 2μM R00 exp25	2.57
Temozolomide 200μM R04 exp189	2.58
B02 10μM R08 exp453	2.61
Momordin-Ic 10μM R08 exp506	2.67
Erlotinib 10μM R05 exp216	3.13
Nicotine 3000μM R08 exp510	3.18
PF-06409577 20μM R07 exp389	3.27
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	3.87
GSK626616 14μM R08 exp485	4.82
MK2206 4μM R08 exp504	7.7

Gene	Correlation
NPRL3	0.849
DEPDC5	0.808
SZT2	0.796
KPTN	0.737
ITFG2	0.713
C12orf66	0.691
TSC2	0.664
TSC1	0.626
SESN2	0.591
CCDC130	0.485
ZFP36L2	0.464
MSI2	0.43
FAM122A	0.414
ANP32A	0.411
NANS	0.402
IPPK	0.401

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12763
Expression level (log2 read counts): 4.59

Expression Distribution