DNAJC3
Gene Information
- Official Symbol: DNAJC3
- Official Name: DnaJ heat shock protein family (Hsp40) member C3
- Aliases and Previous Symbols: N/A
- Entrez ID: 5611
- UniProt: Q13217
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010].
- UniProt Summary: Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. {ECO:0000250|UniProtKB:Q27968, ECO:0000250|UniProtKB:Q91YW3, ECO:0000269|PubMed:12601012, ECO:0000269|PubMed:8576172, ECO:0000269|PubMed:9447982, ECO:0000269|PubMed:9920933}.
Pfam Domains GO Terms
Pfam Domains
| TPR 1 |
| DnaJ |
GO Terms
| positive regulation of translation initiation in response to endoplasmic reticulum stress |
| positive regulation of translation in response to endoplasmic reticulum stress |
| regulation of translation initiation in response to endoplasmic reticulum stress |
| negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation |
| positive regulation of translational initiation in response to stress |
| positive regulation of translation in response to stress |
| regulation of translation in response to endoplasmic reticulum stress |
| cellular response to cold |
| regulation of translational initiation in response to stress |
| regulation of translation in response to stress |
| protein folding in endoplasmic reticulum |
| misfolded protein binding |
| smooth endoplasmic reticulum |
| protein kinase inhibitor activity |
| positive regulation of translational initiation |
| negative regulation of response to endoplasmic reticulum stress |
| response to cold |
| extracellular vesicle |
| IRE1-mediated unfolded protein response |
| regulation of translational initiation |
| regulation of response to endoplasmic reticulum stress |
| azurophil granule lumen |
| chaperone binding |
| endoplasmic reticulum unfolded protein response |
| positive regulation of translation |
| cellular response to unfolded protein |
| unfolded protein binding |
| cellular response to topologically incorrect protein |
| positive regulation of cellular amide metabolic process |
| response to unfolded protein |
| response to temperature stimulus |
| response to topologically incorrect protein |
| defense response to virus |
| negative regulation of protein kinase activity |
| protein folding |
| negative regulation of kinase activity |
| response to endoplasmic reticulum stress |
| negative regulation of transferase activity |
| response to virus |
| endoplasmic reticulum lumen |
| regulation of translation |
| post-translational protein modification |
| regulation of cellular amide metabolic process |
| negative regulation of protein phosphorylation |
| negative regulation of phosphorylation |
| protein kinase binding |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| posttranscriptional regulation of gene expression |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| myeloid leukocyte activation |
| proteolysis involved in cellular protein catabolic process |
| negative regulation of protein modification process |
| cellular protein catabolic process |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| protein catabolic process |
| regulated exocytosis |
| regulation of cellular response to stress |
| leukocyte mediated immunity |
| negative regulation of catalytic activity |
| exocytosis |
| regulation of protein kinase activity |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| cellular macromolecule catabolic process |
| negative regulation of programmed cell death |
| leukocyte activation |
| defense response to other organism |
| regulation of transferase activity |
| negative regulation of cell death |
| secretion by cell |
| endoplasmic reticulum |
| negative regulation of cellular protein metabolic process |
| export from cell |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| cell activation |
| immune effector process |
| negative regulation of protein metabolic process |
| secretion |
| negative regulation of molecular function |
| response to abiotic stimulus |
| proteolysis |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| regulation of cell death |
| cellular response to stress |
| positive regulation of protein metabolic process |
| organic substance catabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| regulation of protein modification process |
| immune response |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| MANF | 0.73 |
| UBE2J1 | 0.665 |
| DNAJB11 | 0.598 |
| ALG5 | 0.593 |
| DERL1 | 0.579 |
| UBE2G2 | 0.578 |
| DERL2 | 0.563 |
| TMED10 | 0.556 |
| IRF2BP2 | 0.528 |
| ALG6 | 0.517 |
| SEC62 | 0.507 |
| TMEM41B | 0.505 |
| ENY2 | 0.502 |
| UFM1 | 0.502 |
| VMP1 | 0.502 |
| XPO6 | 0.502 |
| RNMT | 0.5 |
| SLC35B1 | 0.496 |
| DPAGT1 | 0.494 |
| ALG9 | 0.493 |
| C1orf27 | 0.487 |
| THOC6 | 0.485 |
| UBA5 | 0.481 |
| CBFB | 0.48 |
| DDX5 | 0.478 |
| MBTPS2 | 0.478 |
| ALG1 | 0.476 |
| MLLT1 | 0.475 |
| PMM2 | 0.475 |
| CCDC101 | 0.475 |
| ATP5O | 0.474 |
| SEC63 | 0.471 |
| GTF3C2 | 0.462 |
| TRMT10A | 0.46 |
| OS9 | 0.46 |
| SLC33A1 | 0.459 |
| BAP1 | 0.452 |
| NXT1 | 0.452 |
| KCMF1 | 0.452 |
| MAPK14 | 0.451 |
| GMPPB | 0.451 |
| RPTOR | 0.45 |
| ATP5J | 0.449 |
| DPM3 | 0.448 |
| PPP2R3C | 0.448 |
| ALG3 | 0.445 |
| TTI1 | 0.445 |
| CSNK2B | 0.44 |
| MED16 | 0.439 |
| GTF3C4 | 0.438 |
| GFPT1 | 0.438 |
| NUPL2 | 0.437 |
| FLI1 | 0.436 |
| UFC1 | 0.435 |
| OTUD5 | 0.435 |
| UAP1 | 0.431 |
| SRP68 | 0.428 |
| DHX29 | 0.427 |
| AUP1 | 0.423 |
| OPA1 | 0.42 |
| ATP5A1 | 0.419 |
| PDAP1 | 0.418 |
| ATP5B | 0.417 |
| XPOT | 0.416 |
| EIF1 | 0.416 |
| VCPIP1 | 0.416 |
| LSMD1 | 0.415 |
| ALG8 | 0.415 |
| MED25 | 0.414 |
| ATP5D | 0.414 |
| DHRSX | 0.413 |
| SOX7 | 0.413 |
| TRIAP1 | 0.412 |
| HSP90B1 | 0.411 |
| HSPD1 | 0.411 |
| HARS | 0.408 |
| MEAF6 | 0.408 |
| ALG2 | 0.408 |
| POLR3C | 0.406 |
| DAD1 | 0.404 |
| TLE4 | 0.404 |
| DOHH | 0.404 |
| ATP2A2 | 0.404 |
| FAF2 | 0.404 |
| SEC16A | 0.403 |
| DHDDS | 0.402 |
| DOLK | 0.402 |
| ALG12 | 0.402 |
| AARS | 0.402 |
| ID3 | 0.401 |
| WDR24 | 0.401 |
| RPS6KB1 | 0.401 |
| SMG9 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4356
- Expression level (log2 read counts): 6.2
Expression Distribution
DNAJC3 Expression in NALM6 Cells: 6.2
