LAMTOR4

Gene Information

Official Symbol: LAMTOR4
Official Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
Aliases and Previous Symbols: N/A
Entrez ID: 389541
UniProt: Q0VGL1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. {ECO:0000269|PubMed:22980980}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Wortmannin 5μM R00 exp38	-3.27
CB-839 10μM R05 exp224	-3.18
Rapamycin 1μM R00 exp29	-2.96
Apcin 25μM plus proTAME 2μM R04 exp177	-2.85
Benzoate 10000μM R08 exp455	-2.59
Cycloheximide 0.2μM R00 exp15	-2.58
Nocodazole 0.02μM R00 exp23	-2.53
PF-06409577 20μM R07 exp389	-2.53
Rapamycin 10μM R00 exp30	-2.53
Rapamycin 2μM plus FK-506 5μM R07 exp308	-2.49
5-Fluorouracil 2μM R00 exp1	-2.44
Ribavirin 10 to 15μM on day4 R04 exp160	-2.43
Cycloheximide 0.02μM R00 exp14	-2.42
INK128 0.2μM R02 exp70	-2.38
Rapamycin 0.001μM R08 exp429	-2.32
RO-3306 3 to 4μM on day4 R04 exp165	-2.26
Dexamethasone 0.006μM R07 exp351	-2.16
Torin1 0.08μM R02 exp82	-2.12
CCCP 0.1μM R00 exp10	-2.11
Oligomycin-A 2μM R00 exp25	-2.11
WYE-354 6μM R02 exp90	-2.11
B02 10μM R08 exp453	-2.09
Betulinic acid 10 to 15μM on day4 R05 exp222	-2.08
Chloramphenicol 2μM R00 exp12	-2.02
Doxycycline 10μM R00 exp18	-1.99
ETC-159 50μM R08 exp480	-1.99
Chloramphenicol 20μM R00 exp13	-1.98
Cincreasin 100μM R08 exp473	-1.91
Lead acetate 2000μM R08 exp497	-1.9
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-1.89
NFN1 1μM R03 exp100	-1.88
Adefovir 20μM R07 exp332	-1.87
D-Fructose 10000μM R06 exp279	-1.85
Hydroxychloroquine 30μM R08 exp490	-1.81
Trientine 500μM R08 exp534	-1.8
KU-0063794 3.8μM R02 exp71	-1.78
Hypoxia 5%O2 R04 exp191	-1.75
Wortmannin 0.5μM R00 exp37	-1.74
DABN 2μM R00 exp16	-1.73
Rifampicin 1μM R00 exp31	-1.72
Bisphenol F 50μM R08 exp457	-1.7
proTAME 5μM R04 exp187	-1.7
CFI-400945 25μM R08 exp469	1.72
SNS-032 15μM R08 exp443	1.72
UM0125461 0.74μM R02 exp84	1.75
Mitomycin-C 0.06μM R08 exp503	1.79
UM131593 0.2μM R03 exp106	1.79
LY2090314 0.003μM R08 exp500 no dilution day6	1.85
LY2090314 0.003μM R08 exp499	1.93
Monensin 0.3μM R08 exp507	1.97
JQ1 0.8μM R08 exp435	1.98
Tanespimycin 14μM R08 exp527	2.09
PU-H71 1μM R08 exp515	2.1
Doxorubicin 0.02μM R08 exp478	2.12
CR131-b 0.005μM R08 exp474	2.21
AICAR 240μM R05 exp211	2.22
Ammonium tetrathiomolybdate 10μM R08 exp448	2.25
Aminopterin 0.005μM R07 exp335	2.48
Atovaquone 15μM R08 exp451	2.49
MLN-4924 0.2μM R00 exp21	2.57
Artemisinin 50μM R08 exp450	2.67
TRAIL 50ng/ml R00 exp36	2.69
Hinokiflavone 12μM R08 exp487	2.91
TRAIL 5ng/ml R00 exp35	2.94
Benzoate 20000μM R08 exp456	3.3

Gene	Correlation
WDR24	0.724
LAMTOR2	0.698
FLCN	0.682
FNIP1	0.665
RRAGA	0.645
RPTOR	0.626
LAMTOR3	0.605
DOHH	0.6
VPS41	0.568
LAMTOR5	0.563
LAMTOR1	0.556
WDR59	0.554
MIOS	0.553
FBXO11	0.499
MLST8	0.496
MTOR	0.486
TBC1D5	0.484
CBFB	0.477
MLLT1	0.474
CCDC101	0.467
THOC6	0.466
MAPK14	0.462
TBP	0.46
GTF2A2	0.46
GNB1L	0.457
THG1L	0.457
RFWD2	0.455
UBE2G2	0.455
MED23	0.452
ZNF592	0.445
BAK1	0.441
TUFM	0.441
VHL	0.439
TRIAP1	0.438
TRNT1	0.437
SSBP2	0.436
VDAC2	0.435
PPA2	0.435
GFPT1	0.435
ID3	0.434
ROMO1	0.431
PMM2	0.426
SRP14	0.426
MEAF6	0.425
ACTB	0.425
ENY2	0.424
EXOC4	0.424
GMPPB	0.424
SUPV3L1	0.423
EIF4E	0.422
RNMT	0.422
OPA1	0.421
CYCS	0.419
DCAF5	0.416
C21orf59	0.415
CASP9	0.415
LSM10	0.415
ALG1	0.414
PIM1	0.413
SLC4A7	0.412
ALG5	0.412
RPE	0.411
ATF7IP	0.411
RTCB	0.41
SERF2	0.41
CAMK2G	0.409
ADSL	0.408
HAUS8	0.407
TRMT10A	0.407
NSD1	0.406
EIF3F	0.406
TMEM41B	0.406
DPAGT1	0.405
CASP3	0.405
PDPK1	0.403
TAZ	0.402
GTF3C3	0.402
UHRF1	0.401
EED	0.4

Global Fraction of Cell Lines Where Essential: 60/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	1/28
bone	1/26
breast	6/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	2/21
liver	0/20
lung	6/75
lymphocyte	3/16
ovary	4/26
pancreas	1/24
peripheral nervous system	1/16
plasma cell	4/15
prostate	0/1
skin	1/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	3/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 11265
Expression level (log2 read counts): 4.98

Expression Distribution