AAMP

Gene Information

Official Symbol: AAMP
Official Name: angio associated migratory cell protein
Aliases and Previous Symbols: N/A
Entrez ID: 14
UniProt: Q13685
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate smooth muscle cell migration via the RhoA pathway. The encoded protein can bind to heparin and may mediate heparin-sensitive cell adhesion. [provided by RefSeq, Oct 2014].
UniProt Summary: Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway. {ECO:0000269|PubMed:10329261, ECO:0000269|PubMed:18634987}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tanespimycin 14μM R08 exp527	-2.42
Hinokiflavone 12μM R08 exp487	-1.93
Asunaprenir 3μM R07 exp336	1.71
CHIR-124 0.04μM R06 exp272	1.71
GSK-J4 1μM R07 exp362	1.72
Fas-L 44ng/ml R08 exp482	1.74
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	1.85
Mdivi-1 15μM R05 exp217	1.86
BI-2536 0.001μM R01 exp41	1.87
Wiskostatin 3μM R07 exp422	1.87
Docosahexaenoic-acid 50μM R07 exp356	1.92
Colchicine 0.009μM R05 exp215	1.93
YM155 0.0002μM R01 exp61	1.93
ABT-702 5μM R06 exp261	1.99
Nocodazole 0.02μM R00 exp23	2.19
Ribavirin 10μM R01 exp52	2.23
Adefovir 20μM R07 exp332	2.53
NN-Diethyl-meta-toluamide 100μM R05 exp237	3.65

Gene	Correlation
CHD4	0.589
NPIPB5	0.57
PSMB4	0.55
TCEB3C	0.545
TCEB3CL2	0.542
VASN	0.539
C14orf93	0.528
TCEB3CL	0.519
NUPL1	0.518
DTL	0.517
SAP30BP	0.514
CDH24	0.51
COPG1	0.51
CBWD3	0.508
RPS2	0.506
UTP3	0.501
SF3A1	0.498
TBC1D3H	0.498
CCDC64B	0.497
PSMD11	0.496
IK	0.495
TPX2	0.494
RANBP2	0.493
ORC1	0.493
COPB1	0.492
HIST1H2BE	0.491
PSMC2	0.49
EIF4A3	0.486
CBWD6	0.485
PAN3	0.484
TICRR	0.48
ARCN1	0.479
NOP16	0.478
DISP2	0.478
SUPT5H	0.477
SUPT6H	0.476
NOL10	0.475
CLN6	0.475
GOSR2	0.475
CBWD5	0.473
AQR	0.473
POLE	0.472
NAPA	0.471
TBC1D3G	0.469
COPA	0.469
TP53TG3B	0.469
TP53TG3	0.468
POLR2F	0.468
CEP192	0.468
TP53TG3C	0.468
SLC6A17	0.465
RPL12	0.464
MYB	0.463
OR10G3	0.462
KPNB1	0.462
PSMA6	0.462
DOCK6	0.461
TBC1D3	0.461
GOLGA8O	0.46
GOLGA6A	0.46
ORC6	0.46
TWISTNB	0.46
NUMA1	0.458
SLC4A1	0.457
GOLGA6L1	0.456
TIMELESS	0.455
TBC1D3F	0.455
CCNA2	0.454
C1QTNF9B	0.454
MT1E	0.454
RPS19	0.453
DDT	0.452
NARFL	0.452
RRP1	0.452
NCAPG	0.451
ATP6V1A	0.451
POLA2	0.45
ATXN1	0.45
COL2A1	0.45
HINFP	0.449
PSMD14	0.449
PSMB2	0.448
RRS1	0.448
EXOSC6	0.448
TSPY8	0.448
NUP160	0.448
PAF1	0.446
SNRPA1	0.445
ZNF655	0.444
VPS54	0.444
AKT1S1	0.444
PPFIA4	0.444
DDTL	0.444
ZNF830	0.444
MYLK3	0.443
MED14	0.443
ANKLE1	0.443
KCTD17	0.443
LRR1	0.443
KIF3C	0.442
RAD51	0.441
COPE	0.441
ZNF106	0.441
COX7A2L	0.44
XYLT2	0.437
TBC1D3I	0.437
TBC1D3E	0.437
TBC1D3L	0.437
CHAF1A	0.436
ATP6AP1	0.436
SEC13	0.436
TBC1D3K	0.436
HIST1H4B	0.435
SNIP1	0.435
TP53TG3D	0.434
PNO1	0.434
RBM39	0.432
GOLGA6L3	0.431
PSMA7	0.43
ANKLE2	0.43
RPL35	0.43
RPS7	0.428
EXD1	0.427
LAD1	0.427
CDCA3	0.426
IGFN1	0.425
POLR1A	0.425
RRP7A	0.425
RBBP5	0.424
CACTIN	0.424
TBC1D3C	0.424
VPS28	0.423
AKIRIN2	0.423
EGR2	0.423
RFFL	0.422
HIST2H3A	0.422
HIST2H3C	0.422
PSMD2	0.422
BRD2	0.422
GAR1	0.422
TFIP11	0.422
HNRNPA1	0.421
NUP133	0.42
INTS5	0.42
EXOSC5	0.419
PRIM1	0.419
STIL	0.418
POLA1	0.417
MFSD12	0.416
ACSF2	0.415
KRT2	0.415
INTS1	0.415
RRP15	0.414
POLR2J3	0.414
PAN2	0.414
TSG101	0.414
TUBA8	0.414
RPL6	0.413
MYT1L	0.413
ABHD8	0.411
C3orf17	0.411
COPB2	0.411
FCN2	0.411
TAF1	0.41
RPS12	0.41
RPS9	0.409
MCOLN1	0.409
FAM231C	0.409
NSF	0.408
FAM231A	0.408
NDC80	0.407
SNX15	0.407
ZFAND5	0.406
RRN3	0.406
CWC22	0.406
CTR9	0.404
ZNF574	0.404
PSMD6	0.403
SNRNP200	0.402
MED15	0.402
PARP3	0.402
GPRIN2	0.401
MYO1H	0.401
S1PR4	0.401
SPRR2B	0.401
RPL9	0.401
RNPC3	0.401
FAM160A1	0.4
NUP153	0.4
AATF	0.4

Global Fraction of Cell Lines Where Essential: 117/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	3/28
blood	4/28
bone	3/26
breast	3/33
central nervous system	8/56
cervix	1/4
colorectal	3/17
esophagus	1/13
fibroblast	0/1
gastric	1/16
kidney	6/21
liver	1/20
lung	8/75
lymphocyte	2/16
ovary	5/26
pancreas	6/24
peripheral nervous system	7/16
plasma cell	1/15
prostate	0/1
skin	5/24
soft tissue	1/9
thyroid	1/2
upper aerodigestive	3/22
urinary tract	2/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 538
Expression level (log2 read counts): 5.79

Expression Distribution

smooth muscle cell migration
muscle cell migration
intercellular bridge
ribosomal large subunit biogenesis
positive regulation of endothelial cell migration
unfolded protein binding
positive regulation of epithelial cell migration
microtubule cytoskeleton
regulation of endothelial cell migration
heparin binding
regulation of epithelial cell migration
ribosome biogenesis
angiogenesis
blood vessel morphogenesis
ribonucleoprotein complex biogenesis
blood vessel development
positive regulation of cell migration
vasculature development
cardiovascular system development
positive regulation of cell motility
positive regulation of cellular component movement
positive regulation of locomotion
cell surface
tube morphogenesis
tube development
regulation of cell migration
circulatory system development
anatomical structure formation involved in morphogenesis
regulation of cell motility
cell migration
regulation of locomotion
regulation of cellular component movement
localization of cell
cell motility
locomotion
movement of cell or subcellular component
positive regulation of multicellular organismal process