DHRSX

Gene Information

Official Symbol: DHRSX
Official Name: dehydrogenase/reductase X-linked
Aliases and Previous Symbols: N/A
Entrez ID: 207063
UniProt: Q8N5I4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in the positive regulation of starvation- induced autophagy (PubMed:25076851). {ECO:0000269|PubMed:25076851}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Golgicide-A 4μM R03 exp122	-2.27
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-2.26
Tunicamycin 0.04μM R07 exp418	-2.13
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-2.11
Metformin 40μM R03 exp132	-2.06
UM0011500 5μM R05 exp245	-2.05
UM0011500 10μM R05 exp246	-1.91
HMS-I2 1μM R06 exp286	-1.79
Trimetrexate 0.03μM R08 exp535	1.73
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.75
Milciclib 2μM R08 exp502	1.75
GSK-J4 1-1.25μM to day4 R07 exp363	1.76
CB-5083 0.4μM R08 exp468	1.77
GSK-J4 1.5μM R08 exp441	1.79
Vinblastine 0.015μM R05 exp208	1.85
TIC10 10μM R08 exp532	1.96
LLY-283 2.6μM R06 exp290	2.05
ONC212 0.15μM R08 exp513	2.17
Rotenone 0.07μM R08 exp431	2.21
Amiloride 100μM R08 exp447	2.3
QNZ 0.01μM R08 exp439	2.32
iCRT14 30μM R08 exp492	2.42

Gene	Correlation
PGM3	0.704
SRD5A3	0.664
TRMT61A	0.637
PMVK	0.636
ALG6	0.623
DOLK	0.617
PPCDC	0.608
ALG8	0.604
YARS2	0.597
KIAA0391	0.592
KDSR	0.588
LSM10	0.578
SRP14	0.572
MBTPS2	0.57
MRPL21	0.567
HSD17B10	0.562
BCS1L	0.559
ALG1	0.557
SEC62	0.556
SCO2	0.555
UAP1	0.554
THG1L	0.553
PPA2	0.551
DNLZ	0.547
DPAGT1	0.544
RPIA	0.542
MRPL23	0.539
FH	0.539
TEN1	0.538
PARS2	0.536
MRPS6	0.536
DAP3	0.532
FASTKD5	0.531
RBFA	0.527
SSB	0.527
PMM2	0.526
TRIAP1	0.523
MRPS34	0.523
MRPS11	0.522
MRPS5	0.521
PPCS	0.52
TRMT6	0.52
DARS2	0.519
GTF3C6	0.516
MRPS14	0.516
SELRC1	0.516
ATXN10	0.515
PTPMT1	0.514
CHCHD4	0.512
GEMIN7	0.51
RFT1	0.51
GATC	0.51
ROMO1	0.51
NARS2	0.509
MRPL53	0.504
RABGGTB	0.504
MSTO1	0.504
MRPS18A	0.5
URM1	0.5
EARS2	0.498
POLG	0.498
RPUSD4	0.497
RPE	0.497
SLC25A26	0.497
TARS2	0.496
PTAR1	0.495
ELP6	0.493
ALG3	0.49
TMEM242	0.489
GFM1	0.488
SUPV3L1	0.486
ATIC	0.486
PTDSS1	0.485
DOHH	0.484
TAMM41	0.484
ATP5A1	0.483
LARS2	0.482
DPM3	0.48
ELP3	0.478
MRPL47	0.477
PDAP1	0.477
VEZT	0.477
C10orf2	0.473
MRPS24	0.471
MRP63	0.47
MRPS26	0.469
PGS1	0.467
PGGT1B	0.466
RPP21	0.466
VARS2	0.466
SPR	0.465
DPM1	0.465
TRMT10A	0.464
ATP2A2	0.463
EEF1E1	0.463
UBE2G2	0.462
MRPS16	0.462
MRPS33	0.461
RNASEH1	0.46
TUFM	0.459
MRPS2	0.459
C1D	0.458
ATP5J	0.458
ELAC2	0.457
GEMIN8	0.456
GFPT1	0.456
SARS2	0.454
GEMIN6	0.454
C12orf65	0.454
EIF3F	0.453
ELP2	0.451
QRSL1	0.451
TKT	0.451
MOCS3	0.45
CDIPT	0.45
CEPT1	0.45
ALDH18A1	0.449
GFM2	0.449
PPP6C	0.449
RARS2	0.448
HCCS	0.448
TPK1	0.446
C15orf41	0.446
ZRSR2	0.445
AASDHPPT	0.444
ALG9	0.441
MRPS21	0.441
GTF3C4	0.44
TEFM	0.44
PIK3R4	0.44
C17orf89	0.44
ALG13	0.44
TIMM22	0.439
PDCD5	0.437
USO1	0.437
NBN	0.437
ALG5	0.436
IRF2BP2	0.436
CXorf56	0.436
ATP5C1	0.435
MRPS17	0.435
WBSCR16	0.434
COX16	0.433
UHRF1	0.432
MBTPS1	0.432
POLG2	0.432
ATP5D	0.431
VMA21	0.429
UBA5	0.429
ATP5B	0.427
SEC63	0.427
N6AMT1	0.427
DDX20	0.427
HARS2	0.427
COX15	0.426
C11orf57	0.426
DDX39A	0.426
EXOC4	0.426
TTC4	0.425
CRLS1	0.425
PPP2R3C	0.424
TAZ	0.423
MRPL15	0.423
CTU1	0.423
TSEN54	0.419
TAF1A	0.417
OPA1	0.417
COX5A	0.415
DNAJC3	0.413
NDUFAF7	0.411
DNAJB11	0.411
PSMG2	0.41
UGP2	0.409
DHPS	0.409
LSM11	0.409
ATP5O	0.409
FAF2	0.409
MTG1	0.407
MRPL11	0.406
MRPS9	0.406
UQCRQ	0.406
TBCB	0.406
COX7B	0.404
FANCC	0.404
MRPL12	0.403
TMEM41B	0.402
ATP5H	0.402
UQCR10	0.402
MRPS23	0.401
CTC1	0.4
WARS2	0.4
UFC1	0.4

Global Fraction of Cell Lines Where Essential: 54/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	5/28
blood	1/26
bone	0/26
breast	1/30
central nervous system	1/49
cervix	1/4
colorectal	1/17
esophagus	1/11
fibroblast	0/1
gastric	3/14
kidney	1/18
liver	5/19
lung	1/72
lymphocyte	0/16
ovary	0/25
pancreas	2/22
peripheral nervous system	1/15
plasma cell	1/12
prostate	0/1
skin	1/20
soft tissue	0/9
thyroid	1/2
upper aerodigestive	6/22
urinary tract	3/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4180
Expression level (log2 read counts): 2.87

Expression Distribution

adh short
Epimerase
KR

oxidoreductase activity
positive regulation of autophagy
regulation of autophagy
positive regulation of cellular catabolic process
positive regulation of catabolic process
regulation of cellular catabolic process
oxidation-reduction process
regulation of catabolic process
extracellular region