ERAL1

Entrez Summary: N/A
UniProt Summary: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly. {ECO:0000269|PubMed:20430825, ECO:0000269|PubMed:20604745, ECO:0000269|PubMed:28449065}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tubacin 1.6μM R07 exp416	1.72
Rapamycin 2μM plus FK-506 5μM R07 exp308	1.76
Vemurafenib 6.6μM R02 exp89	1.91
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.95
UM0125461 0.74μM R02 exp84	1.97
Etoposide 0.1μM R05 exp198	2.06
Hydroxyurea 100μM R07 exp329	2.09
Oligomycin-A 2μM R00 exp25	2.35

Global Fraction of Cell Lines Where Essential: 9/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	1/5

Expression Distribution

ribosomal small subunit binding
ribosomal small subunit assembly
rRNA binding
ribosome assembly
ribosomal small subunit biogenesis
mitochondrial translational termination
mitochondrial translational elongation
translational termination
mitochondrial translation
translational elongation
cellular protein complex disassembly
mitochondrial gene expression
ribonucleoprotein complex assembly
protein-containing complex disassembly
ribonucleoprotein complex subunit organization
ribosome biogenesis
mitochondrial matrix
translation
GTP binding
mitochondrial inner membrane
cellular component disassembly
peptide biosynthetic process
ribonucleoprotein complex biogenesis
amide biosynthetic process
peptide metabolic process
organelle assembly
cellular amide metabolic process
cellular protein-containing complex assembly
mitochondrion
RNA binding
organonitrogen compound biosynthetic process
protein-containing complex assembly
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression